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Rps21 ribosomal protein S21 [ Mus musculus (house mouse) ]

Gene ID: 66481, updated on 5-Mar-2024

Summary

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Official Symbol
Rps21provided by MGI
Official Full Name
ribosomal protein S21provided by MGI
Primary source
MGI:MGI:1913731
See related
Ensembl:ENSMUSG00000039001 AllianceGenome:MGI:1913731
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1810049N11Rik; 2410030A14Rik
Summary
Predicted to enable protein N-terminus binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in cytoplasmic translation; endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); and endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in synapse. Orthologous to human RPS21 (ribosomal protein S21). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 1055.6), spleen adult (RPKM 751.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Rps21 in Genome Data Viewer
Location:
2 H4; 2 102.78 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (179899172..179900237)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (180257379..180258444)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene adhesion regulating molecule 1 26S proteasome ubiquitin receptor Neighboring gene laminin, alpha 5 Neighboring gene microRNA 7005 Neighboring gene STARR-seq mESC enhancer starr_06728 Neighboring gene STARR-seq mESC enhancer starr_06729 Neighboring gene STARR-positive B cell enhancer ABC_E6036 Neighboring gene microRNA 3091 Neighboring gene CDK5 and Abl enzyme substrate 2 Neighboring gene STARR-positive B cell enhancer ABC_E333 Neighboring gene RBBP8 N-terminal like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Disruption of entire Cables2 locus leads to embryonic lethality by diminished Rps21 gene expression and enhanced p53 pathway. Dinh TTH, et al. Elife, 2021 May 5. PMID 33949947, Free PMC Article
  2. Maternal DCAF13 Regulates Chromatin Tightness to Contribute to Embryonic Development. Liu Y, et al. Sci Rep, 2019 Apr 18. PMID 31000741, Free PMC Article
  3. Drp1 regulates transcription of ribosomal protein genes in embryonic hearts. Zhao Q, et al. J Cell Sci, 2022 Feb 15. PMID 35099001, Free PMC Article
  4. A novel view of the transcriptome revealed from gene trapping in mouse embryonic stem cells. Roma G, et al. Genome Res, 2007 Jul. PMID 17540781, Free PMC Article
  5. Comprehensive interactome of Otx2 in the adult mouse neural retina. Fant B, et al. Genesis, 2015 Nov. PMID 26426291

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Disruption of entire Cables2 locus leads to embryonic lethality by diminished Rps21 gene expression and enhanced p53 pathway.
    Title: Disruption of entire Cables2 locus leads to embryonic lethality by diminished Rps21 gene expression and enhanced p53 pathway.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC107620

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic translation ISO
Inferred from Sequence Orthology
more info
  
involved_in cytoplasmic translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
  
part_of cytosolic small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic small ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic small ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
part_of cytosolic small ribosomal subunit NAS
Non-traceable Author Statement
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynapse NAS
Non-traceable Author Statement
more info
 PubMed 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in ribosome NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
small ribosomal subunit protein eS21
Names
40S ribosomal protein S21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355516.1 → NP_001342445.1  small ribosomal subunit protein eS21

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All six variants encode the same protein.
    Source sequence(s)
    AL663027
    Consensus CDS
    CCDS38376.1
    UniProtKB/Swiss-Prot
    Q5M9L3, Q9CQR2
    UniProtKB/TrEMBL
    Q8C1L7
    Conserved Domains (1) summary
    pfam01249
    Location:1 → 80
    Ribosomal_S21e; Ribosomal protein S21e

  2. NM_001355517.1 → NP_001342446.1  small ribosomal subunit protein eS21

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.
    Source sequence(s)
    AI664432, AL663027
    Consensus CDS
    CCDS38376.1
    UniProtKB/Swiss-Prot
    Q5M9L3, Q9CQR2
    UniProtKB/TrEMBL
    Q8C1L7
    Conserved Domains (1) summary
    pfam01249
    Location:1 → 80
    Ribosomal_S21e; Ribosomal protein S21e

  3. NM_001355518.1 → NP_001342447.1  small ribosomal subunit protein eS21

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.
    Source sequence(s)
    AL663027, BY707853
    Consensus CDS
    CCDS38376.1
    UniProtKB/Swiss-Prot
    Q5M9L3, Q9CQR2
    UniProtKB/TrEMBL
    Q8C1L7
    Conserved Domains (1) summary
    pfam01249
    Location:1 → 80
    Ribosomal_S21e; Ribosomal protein S21e

  4. NM_001355520.1 → NP_001342449.1  small ribosomal subunit protein eS21

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.
    Source sequence(s)
    AL663027
    Consensus CDS
    CCDS38376.1
    UniProtKB/Swiss-Prot
    Q5M9L3, Q9CQR2
    UniProtKB/TrEMBL
    Q8C1L7
    Conserved Domains (1) summary
    pfam01249
    Location:1 → 80
    Ribosomal_S21e; Ribosomal protein S21e

  5. NM_001355521.1 → NP_001342450.1  small ribosomal subunit protein eS21

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.
    Source sequence(s)
    AL663027
    Consensus CDS
    CCDS38376.1
    UniProtKB/Swiss-Prot
    Q5M9L3, Q9CQR2
    UniProtKB/TrEMBL
    Q8C1L7
    Conserved Domains (1) summary
    pfam01249
    Location:1 → 80
    Ribosomal_S21e; Ribosomal protein S21e

  6. NM_025587.2 → NP_079863.1  small ribosomal subunit protein eS21

    See identical proteins and their annotated locations for NP_079863.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.
    Source sequence(s)
    AA049954, BU534365
    Consensus CDS
    CCDS38376.1
    UniProtKB/Swiss-Prot
    Q5M9L3, Q9CQR2
    UniProtKB/TrEMBL
    Q8C1L7
    Related
    ENSMUSP00000058432.7, ENSMUST00000059080.7
    Conserved Domains (1) summary
    pfam01249
    Location:1 → 80
    Ribosomal_S21e; Ribosomal protein S21e

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    179899172..179900237
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CQR2.1 GenPept UniProtKB/Swiss-Prot:Q9CQR2

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