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BNIP3L BCL2 interacting protein 3 like [ Homo sapiens (human) ]

Gene ID: 665, updated on 5-Mar-2024

Summary

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Official Symbol
BNIP3Lprovided by HGNC
Official Full Name
BCL2 interacting protein 3 likeprovided by HGNC
Primary source
HGNC:HGNC:1085
See related
Ensembl:ENSG00000104765 MIM:605368; AllianceGenome:HGNC:1085
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NIX; NIP3L; BNIP3a
Summary
This gene encodes a protein that belongs to the pro-apoptotic subfamily within the Bcl-2 family of proteins. The encoded protein binds to Bcl-2 and possesses the BH3 domain. The protein directly targets mitochondria and causes apoptotic changes, including loss of membrane potential and the release of cytochrome c. [provided by RefSeq, Feb 2015]
Expression
Ubiquitous expression in fat (RPKM 69.4), ovary (RPKM 49.9) and 24 other tissues See more
Orthologs
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Genomic context

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See BNIP3L in Genome Data Viewer
Location:
8p21.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (26383054..26413127)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (26659614..26689692)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (26240570..26270643)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19038 Neighboring gene protein phosphatase 2 regulatory subunit Balpha Neighboring gene Sharpr-MPRA regulatory region 13890 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:26192157-26192656 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:26239047-26240246 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27126 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19039 Neighboring gene Sharpr-MPRA regulatory region 12075 Neighboring gene SDA1 domain containing 1 pseudogene 1 Neighboring gene GATA motif-containing MPRA enhancer 260 Neighboring gene Sharpr-MPRA regulatory region 1267 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27127 Neighboring gene DNAJB6 pseudogene 2 Neighboring gene vegetative cell wall protein gp1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19040 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19041 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19042

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A brief overview of BNIP3L/NIX receptor-mediated mitophagy. Marinković M, et al. FEBS Open Bio, 2021 Dec. PMID 34597467, Free PMC Article
  2. Expression and Clinical Significance of BCL2 Interacting Protein 3 Like in Multiple Myeloma. Li R, et al. Technol Cancer Res Treat, 2021 Jan-Dec. PMID 34189969, Free PMC Article
  3. NIX-mediated mitophagy regulate metabolic reprogramming in phagocytic cells during mycobacterial infection. Mahla RS, et al. Tuberculosis (Edinb), 2021 Jan. PMID 33421909
  4. BNIP3L/Nix-induced mitochondrial fission, mitophagy, and impaired myocyte glucose uptake are abrogated by PRKA/PKA phosphorylation. da Silva Rosa SC, et al. Autophagy, 2021 Sep. PMID 33044904, Free PMC Article
  5. BNIP3L Is a New Autophagy Related Prognostic Biomarker for Melanoma Patients Treated With AGI-101H. Kazimierczak U, et al. Anticancer Res, 2020 Jul. PMID 32620611

See all (88) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Excessive BNIP3- and BNIP3L-dependent mitophagy underlies the pathogenesis of FBXL4-mutated mitochondrial DNA depletion syndrome.
    Title: Excessive BNIP3- and BNIP3L-dependent mitophagy underlies the pathogenesis of FBXL4-mutated mitochondrial DNA depletion syndrome.
  2. Uncovering interactions of mitochondrial proteins BNIP3 and BNIP3L with necroptosis-associated kinase RIPK3: Insights into kinase activation.
    Title: Uncovering interactions of mitochondrial proteins BNIP3 and BNIP3L with necroptosis-associated kinase RIPK3: Insights into kinase activation.
  3. FBXL4 ubiquitin ligase deficiency promotes mitophagy by elevating NIX levels.
    Title: FBXL4 ubiquitin ligase deficiency promotes mitophagy by elevating NIX levels.
  4. The outer mitochondrial membrane protein TMEM11 demarcates spatially restricted BNIP3/BNIP3L-mediated mitophagy.
    Title: The outer mitochondrial membrane protein TMEM11 demarcates spatially restricted BNIP3/BNIP3L-mediated mitophagy.
  5. Mitophagy Effects of Protodioscin on Human Osteosarcoma Cells by Inhibition of p38MAPK Targeting NIX/LC3 Axis.
    Title: Mitophagy Effects of Protodioscin on Human Osteosarcoma Cells by Inhibition of p38MAPK Targeting NIX/LC3 Axis.
  6. BNIP3 and Nix: Atypical regulators of cell fate.
    Title: BNIP3 and Nix: Atypical regulators of cell fate.
  7. BNIP3L/Nix-induced mitochondrial fission, mitophagy, and impaired myocyte glucose uptake are abrogated by PRKA/PKA phosphorylation.
    Title: BNIP3L/Nix-induced mitochondrial fission, mitophagy, and impaired myocyte glucose uptake are abrogated by PRKA/PKA phosphorylation.
  8. A brief overview of BNIP3L/NIX receptor-mediated mitophagy.
    Title: A brief overview of BNIP3L/NIX receptor-mediated mitophagy.
  9. NIX initiates mitochondrial fragmentation via DRP1 to drive epidermal differentiation.
    Title: NIX initiates mitochondrial fragmentation via DRP1 to drive epidermal differentiation.
  10. Expression and Clinical Significance of BCL2 Interacting Protein 3 Like in Multiple Myeloma.
    Title: Expression and Clinical Significance of BCL2 Interacting Protein 3 Like in Multiple Myeloma.
Submit: New GeneRIF Correction See all GeneRIFs (43)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables lamin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables lamin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to hypoxia IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in defense response to virus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response to virus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitochondrial outer membrane permeabilization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of mitochondrial membrane potential IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of programmed cell death IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of macroautophagy IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of mitophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of programmed cell death IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of protein targeting to mitochondrion IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 
is_active_in mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial outer membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in mitochondrial outer membrane TAS
Traceable Author Statement
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like
Names
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A
BCL2/adenovirus E1B 19-kd protein-interacting protein 3a
BCL2/adenovirus E1B 19kDa interacting protein 3 like
NIP-3-like protein X
NIP3-like protein X
adenovirus E1B19k-binding protein B5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330491.2 → NP_001317420.1  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC011726, AK316315, BG942896
    Consensus CDS
    CCDS83267.1
    UniProtKB/TrEMBL
    H0YBC7
    Related
    ENSP00000429851.1, ENST00000518611.5
    Conserved Domains (1) summary
    pfam06553
    Location:17 → 178
    BNIP3

  2. NM_004331.3 → NP_004322.1  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform 1

    See identical proteins and their annotated locations for NP_004322.1

    Status: REVIEWED

    Source sequence(s)
    AA946755, AB004788, AF536326, AL132665, BF337139, BQ719112, CD244492, CD558918
    Consensus CDS
    CCDS6050.1
    UniProtKB/Swiss-Prot
    B0AZS9, O60238, Q5JW63, Q8NF87
    UniProtKB/TrEMBL
    Q6IBV1, Q9H3K3
    Related
    ENSP00000370003.2, ENST00000380629.7
    Conserved Domains (1) summary
    pfam06553
    Location:28 → 218
    BNIP3; BNIP3

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    26383054..26413127
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    26659614..26689692
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O60238.1 GenPept UniProtKB/Swiss-Prot:O60238

Gene LinkOut

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