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SP2 Sp2 transcription factor [ Homo sapiens (human) ]

Gene ID: 6668, updated on 5-Mar-2024

Summary

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Official Symbol
SP2provided by HGNC
Official Full Name
Sp2 transcription factorprovided by HGNC
Primary source
HGNC:HGNC:11207
See related
Ensembl:ENSG00000167182 MIM:601801; AllianceGenome:HGNC:11207
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins, and its DNA sequence specificity differs from the other Sp proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate or in some cases repress expression from different promoters. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 4.3), spleen (RPKM 3.4) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
17q21.32
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (47896236..47931731)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (48758002..48793527)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (45973602..46006323)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:45924483-45925091 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:45931158-45931349 Neighboring gene Sp6 transcription factor Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:45944035-45945234 Neighboring gene CRISPRi-validated cis-regulatory element chr17.3283 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:45963041-45963574 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8643 Neighboring gene Sharpr-MPRA regulatory region 4370 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8644 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:45977450-45977954 Neighboring gene SP2 divergent transcript Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:45978459-45978962 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:45979467-45979970 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:45981458-45981651 Neighboring gene SP2 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:46004735-46005236 Neighboring gene Sharpr-MPRA regulatory region 5948 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12320 Neighboring gene pyridoxamine 5'-phosphate oxidase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:46033917-46034862 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:46034863-46035808 Neighboring gene proline rich 15 like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Transcription factor Sp2 promotes TGFB-mediated interstitial cell osteogenic differentiation in bicuspid aortic valves through a SMAD-dependent pathway. Zheng R, et al. Exp Cell Res, 2022 Feb 1. PMID 34914964
  2. Transcription Factor SP2 Regulates Ski-mediated Astrocyte Proliferation In Vitro. Da CM, et al. Neuroscience, 2021 Dec 15. PMID 34687796
  3. Sp2 promotes invasion and metastasis of hepatocellular carcinoma by targeting TRIB3 protein. Zhu Y, et al. Cancer Med, 2020 May. PMID 32160655, Free PMC Article
  4. Novel Mutation (Gly212Val) in the PS2 Gene Associated with Early-Onset Familial Alzheimer's Disease. Marín-Muñoz J, et al. J Alzheimers Dis, 2016 Apr 25. PMID 27128372
  5. Sp2 localizes to subnuclear foci associated with the nuclear matrix. Moorefield KS, et al. Mol Biol Cell, 2006 Apr. PMID 16467376, Free PMC Article

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Transcription factor Sp2 promotes TGFB-mediated interstitial cell osteogenic differentiation in bicuspid aortic valves through a SMAD-dependent pathway.
    Title: Transcription factor Sp2 promotes TGFB-mediated interstitial cell osteogenic differentiation in bicuspid aortic valves through a SMAD-dependent pathway.
  2. Transcription Factor SP2 Regulates Ski-mediated Astrocyte Proliferation In Vitro.
    Title: Transcription Factor SP2 Regulates Ski-mediated Astrocyte Proliferation In Vitro.
  3. Sp2 promotes invasion and metastasis of hepatocellular carcinoma by targeting TRIB3 protein.
    Title: Sp2 promotes invasion and metastasis of hepatocellular carcinoma by targeting TRIB3 protein.
  4. This study presented that a Novel Mutation (Gly212Val) in the PS2 Gene Associated with Early-Onset Familial Alzheimer's Disease.
    Title: Novel Mutation (Gly212Val) in the PS2 Gene Associated with Early-Onset Familial Alzheimer's Disease.
  5. SP2 recognized binding motifs in the human RORgammaT promoter, which was critical for maintaining expression. SP2 was necessary for maximum IL-17 expression in in vitro-differentiated Th17 cells. SP 2 plays a role in Th17-dependent physiologic and pathologic immune responses.
    Title: Expression of human gene coding RORγT receptor depends on the Sp2 transcription factor.
  6. O-GlcNAc modification of Sp3 and Sp4, but not Sp2 transcription factors negatively regulates their transcriptional activities.
    Title: O-GlcNAc modification of Sp3 and Sp4 transcription factors negatively regulates their transcriptional activities.
  7. Sp2 is up-regulated in gastric cancer tissues
    Title: miR-638 suppresses cell proliferation in gastric cancer by targeting Sp2.
  8. Data show that three Sp1 motifs located between -148 and -42bp upstream of the first exon were important in basic as well as in DA-induced NSMase2 promoter activity.
    Title: Transcriptional regulation of neutral sphingomyelinase 2 gene expression of a human breast cancer cell line, MCF-7, induced by the anti-cancer drug, daunorubicin.
  9. Observational study of gene-disease association. (HuGE Navigator)
    Title: Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging.
  10. Despite the absence of Sp2 in the 5'-upstream sequence of the human promoter, silencing of Sp2 by RNA interference clearly demonstrated that Sp2 is required for IFN-gamma-induced regulation of socs1 mRNA both in human and mouse.
    Title: Sp2 regulates interferon-gamma-mediated socs1 gene expression.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat downregulates Sp2 transcription factor in HEK 293T cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone deacetylase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in immune response TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of chromatin ISA
Inferred from Sequence Alignment
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
transcription factor Sp2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003110.6 → NP_003101.3  transcription factor Sp2

    See identical proteins and their annotated locations for NP_003101.3

    Status: REVIEWED

    Source sequence(s)
    BC016680, BC033814, DB451570, M97190
    Consensus CDS
    CCDS11521.2
    UniProtKB/Swiss-Prot
    A6NK74, Q02086
    Related
    ENSP00000365931.4, ENST00000376741.5
    Conserved Domains (4) summary
    COG5048
    Location:449 → 587
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:530 → 549
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:585 → 607
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:571 → 594
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    47896236..47931731
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011525139.3 → XP_011523441.2  transcription factor Sp2 isoform X6

  2. XM_047436575.1 → XP_047292531.1  transcription factor Sp2 isoform X7

  3. XM_047436573.1 → XP_047292529.1  transcription factor Sp2 isoform X6

  4. XM_047436571.1 → XP_047292527.1  transcription factor Sp2 isoform X6

  5. XM_047436570.1 → XP_047292526.1  transcription factor Sp2 isoform X6

  6. XM_047436572.1 → XP_047292528.1  transcription factor Sp2 isoform X6

  7. XM_017024968.2 → XP_016880457.1  transcription factor Sp2 isoform X6

    Conserved Domains (4) summary
    COG5048
    Location:442 → 580
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:523 → 542
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:578 → 600
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:564 → 587
    zf-H2C2_2; Zinc-finger double domain

  8. XM_006722025.3 → XP_006722088.1  transcription factor Sp2 isoform X6

    See identical proteins and their annotated locations for XP_006722088.1

    Conserved Domains (4) summary
    COG5048
    Location:442 → 580
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:523 → 542
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:578 → 600
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:564 → 587
    zf-H2C2_2; Zinc-finger double domain

  9. XM_006722027.3 → XP_006722090.1  transcription factor Sp2 isoform X6

    See identical proteins and their annotated locations for XP_006722090.1

    Conserved Domains (4) summary
    COG5048
    Location:442 → 580
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:523 → 542
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:578 → 600
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:564 → 587
    zf-H2C2_2; Zinc-finger double domain

  10. XM_011525143.2 → XP_011523445.1  transcription factor Sp2 isoform X6

    See identical proteins and their annotated locations for XP_011523445.1

    Conserved Domains (4) summary
    COG5048
    Location:442 → 580
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:523 → 542
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:578 → 600
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:564 → 587
    zf-H2C2_2; Zinc-finger double domain

  11. XM_006722023.3 → XP_006722086.1  transcription factor Sp2 isoform X4

    Conserved Domains (4) summary
    COG5048
    Location:449 → 587
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:530 → 549
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:585 → 607
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:571 → 594
    zf-H2C2_2; Zinc-finger double domain

  12. XM_047436569.1 → XP_047292525.1  transcription factor Sp2 isoform X5

  13. XM_047436576.1 → XP_047292532.1  transcription factor Sp2 isoform X8

  14. XM_047436577.1 → XP_047292533.1  transcription factor Sp2 isoform X10

  15. XM_011525136.3 → XP_011523438.1  transcription factor Sp2 isoform X1

    Conserved Domains (4) summary
    COG5048
    Location:553 → 718
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:634 → 653
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:689 → 711
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:675 → 698
    zf-H2C2_2; Zinc-finger double domain

  16. XM_011525137.3 → XP_011523439.1  transcription factor Sp2 isoform X2

    Conserved Domains (4) summary
    COG5048
    Location:553 → 718
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:634 → 653
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:689 → 711
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:675 → 698
    zf-H2C2_2; Zinc-finger double domain

  17. XM_011525138.3 → XP_011523440.1  transcription factor Sp2 isoform X3

    Conserved Domains (4) summary
    COG5048
    Location:553 → 718
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:634 → 653
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:689 → 711
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:675 → 698
    zf-H2C2_2; Zinc-finger double domain

  18. XM_011525140.3 → XP_011523442.1  transcription factor Sp2 isoform X9

    Conserved Domains (4) summary
    COG5048
    Location:553 → 691
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:634 → 653
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:689 → 711
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:675 → 698
    zf-H2C2_2; Zinc-finger double domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    48758002..48793527
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054316988.1 → XP_054172963.1  transcription factor Sp2 isoform X10

  2. XM_054316981.1 → XP_054172956.1  transcription factor Sp2 isoform X6

  3. XM_054316978.1 → XP_054172953.1  transcription factor Sp2 isoform X6

  4. XM_054316977.1 → XP_054172952.1  transcription factor Sp2 isoform X6

  5. XM_054316980.1 → XP_054172955.1  transcription factor Sp2 isoform X6

  6. XM_054316982.1 → XP_054172957.1  transcription factor Sp2 isoform X6

  7. XM_054316976.1 → XP_054172951.1  transcription factor Sp2 isoform X6

  8. XM_054316979.1 → XP_054172954.1  transcription factor Sp2 isoform X6

  9. XM_054316983.1 → XP_054172958.1  transcription factor Sp2 isoform X6

  10. XM_054316974.1 → XP_054172949.1  transcription factor Sp2 isoform X4

  11. XM_054316975.1 → XP_054172950.1  transcription factor Sp2 isoform X5

  12. XM_054316986.1 → XP_054172961.1  transcription factor Sp2 isoform X8

  13. XM_054316985.1 → XP_054172960.1  transcription factor Sp2 isoform X7

  14. XM_054316984.1 → XP_054172959.1  transcription factor Sp2 isoform X6

  15. XM_054316971.1 → XP_054172946.1  transcription factor Sp2 isoform X1

  16. XM_054316972.1 → XP_054172947.1  transcription factor Sp2 isoform X2

  17. XM_054316973.1 → XP_054172948.1  transcription factor Sp2 isoform X3

  18. XM_054316987.1 → XP_054172962.1  transcription factor Sp2 isoform X9

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q02086.3 GenPept UniProtKB/Swiss-Prot:Q02086

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