myl2b myosin, light chain 2b, regulatory, cardiac, slow [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: myl2bprovided by ZNC
Official Full Name: myosin, light chain 2b, regulatory, cardiac, slowprovided by ZNC
Primary source: ZFIN:ZDB-GENE-060331-137
See related: Ensembl:ENSDARG00000053424 AllianceGenome:ZFIN:ZDB-GENE-060331-137
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: myl2; mlc2b; zgc:136848
Summary: Predicted to enable calcium ion binding activity. Is expressed in several structures, including brain; eye; gill; heart; and musculature system. Human ortholog(s) of this gene implicated in familial hypertrophic cardiomyopathy and hypertrophic cardiomyopathy 10. Orthologous to human MYL2 (myosin light chain 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 8

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (4333834..4359475)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (4277225..4302769)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cdh2 coordinates Myosin-II dependent internalisation of the zebrafish neural plate.
Title: Cdh2 coordinates Myosin-II dependent internalisation of the zebrafish neural plate.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cardiac muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
involved_in heart development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within heart morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle cell fate specification	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in myofibril	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: myosin, light chain 2b, regulatory, cardiac, slow

Names: myosin regulatory light chain 2b; myosin, light polypeptide 2, regulatory, cardiac, slow; myosin, light polypeptide 2b, regulatory, cardiac, slow

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001040045.1 → NP_001035134.1 myosin, light chain 2b, regulatory, cardiac, slow

See identical proteins and their annotated locations for NP_001035134.1

Status: PROVISIONAL

Source sequence(s)

BC114289

UniProtKB/TrEMBL

A0A385NIA4, Q24JV6

Related

ENSDARP00000116241.1, ENSDART00000137528.3

Conserved Domains (1) summary

COG5126
Location:15 → 163

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007119.7 Reference GRCz11 Primary Assembly

Range

4333834..4359475

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021478314.1 → XP_021333989.1 myosin, light chain 2b, regulatory, cardiac, slow isoform X1

UniProtKB/TrEMBL

A0A8M9Q9U1

Conserved Domains (1) summary

cl25352
Location:44 → 120

EFh_PEF; The penta-EF hand (PEF) family