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Rpl4 ribosomal protein L4 [ Mus musculus (house mouse) ]

Gene ID: 67891, updated on 5-Mar-2024

Summary

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Official Symbol
Rpl4provided by MGI
Official Full Name
ribosomal protein L4provided by MGI
Primary source
MGI:MGI:1915141
See related
Ensembl:ENSMUSG00000032399 AllianceGenome:MGI:1915141
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2010004J23Rik
Summary
Predicted to enable 5S rRNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in positive regulation of axon extension. Predicted to be located in several cellular components, including A band; cytosolic ribosome; and rough endoplasmic reticulum. Predicted to be part of cytosolic large ribosomal subunit. Is expressed in 8-cell stage embryo. Orthologous to human RPL4 (ribosomal protein L4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 606.0), CNS E11.5 (RPKM 541.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Rpl4 in Genome Data Viewer
Location:
9 C; 9 34.54 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (64080159..64085805)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (64173387..64178562)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39360 Neighboring gene lactase-like Neighboring gene zwilch kinetochore protein Neighboring gene STARR-seq mESC enhancer starr_24420 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:64027060-64027169 Neighboring gene STARR-seq mESC enhancer starr_24421 Neighboring gene small nucleolar RNA, C/D box 16A Neighboring gene predicted gene, 23344 Neighboring gene predicted gene, 22571 Neighboring gene predicted gene, 23136 Neighboring gene predicted gene, 22455 Neighboring gene small nuclear RNA activating complex, polypeptide 5 Neighboring gene STARR-seq mESC enhancer starr_24422 Neighboring gene mitogen-activated protein kinase kinase 1 Neighboring gene STARR-seq mESC enhancer starr_24424 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:64075662-64075771 Neighboring gene ubiquitin carboxyl-terminal esterase L4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Large ribosomal protein 4 increases efficiency of viral recoding sequences. Green L, et al. J Virol, 2012 Sep. PMID 22718819, Free PMC Article
  2. Ribosomal protein L4 positively regulates activity of a c-myb proto-oncogene product. Egoh A, et al. Genes Cells, 2010 Aug. PMID 20604807
  3. Cold stress-induced protein Rbm3 binds 60S ribosomal subunits, alters microRNA levels, and enhances global protein synthesis. Dresios J, et al. Proc Natl Acad Sci U S A, 2005 Feb 8. PMID 15684048, Free PMC Article
  4. A novel type of co-chaperone mediates transmembrane recruitment of DnaK-like chaperones to ribosomes. Dudek J, et al. EMBO J, 2002 Jun 17. PMID 12065409, Free PMC Article
  5. Cyclin B1/Cdk1 binds and phosphorylates Filamin A and regulates its ability to cross-link actin. Cukier IH, et al. FEBS Lett, 2007 Apr 17. PMID 17408621

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mouse and human RPL4 enhance MoMLV gag-pol readthrough.
    Title: Large ribosomal protein 4 increases efficiency of viral recoding sequences.
  2. The RPL4 plays an important role in c-myc expression by interacting with c-Myb in response to growth factor and nutritional signals.
    Title: Ribosomal protein L4 positively regulates activity of a c-myb proto-oncogene product.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 5S rRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of axon extension ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of axonogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translation at postsynapse NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in translation at presynapse NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in A band ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic large ribosomal subunit IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of cytosolic large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
located_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
  
part_of large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynapse NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynapse NAS
Non-traceable Author Statement
more info
 PubMed 
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in ribosome NAS
Non-traceable Author Statement
more info
 PubMed 
located_in rough endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in synapse NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
large ribosomal subunit protein uL4
Names
60S ribosomal protein L4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024212.5 → NP_077174.1  large ribosomal subunit protein uL4

    See identical proteins and their annotated locations for NP_077174.1

    Status: VALIDATED

    Source sequence(s)
    AC160118
    Consensus CDS
    CCDS40667.1
    UniProtKB/Swiss-Prot
    Q9CY08, Q9D8E6
    UniProtKB/TrEMBL
    Q564E8
    Related
    ENSMUSP00000034966.8, ENSMUST00000034966.9
    Conserved Domains (1) summary
    PTZ00428
    Location:2 → 352
    PTZ00428; 60S ribosomal protein L4; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    64080159..64085805
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155218.1 → XP_036011111.1  large ribosomal subunit protein uL4 isoform X1

    UniProtKB/Swiss-Prot
    Q9CY08, Q9D8E6
    UniProtKB/TrEMBL
    Q564E8
    Conserved Domains (1) summary
    PTZ00428
    Location:2 → 352
    PTZ00428; 60S ribosomal protein L4; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D8E6.3 GenPept UniProtKB/Swiss-Prot:Q9D8E6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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