U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Gnpda2 glucosamine-6-phosphate deaminase 2 [ Mus musculus (house mouse) ]

Gene ID: 67980, updated on 30-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Gnpda2provided by MGI
Official Full Name
glucosamine-6-phosphate deaminase 2provided by MGI
Primary source
MGI:MGI:1915230
See related
Ensembl:ENSMUSG00000029209 AllianceGenome:MGI:1915230
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gnp2; Sb52; GNPDA; mKIAA4008; 4921523I18Rik; 4933412A11Rik
Summary
Predicted to enable glucosamine-6-phosphate deaminase activity and identical protein binding activity. Predicted to be involved in UDP-N-acetylglucosamine biosynthetic process and amino sugar catabolic process. Predicted to act upstream of or within carbohydrate metabolic process. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; eye; genitourinary system; hemolymphoid system gland; and nervous system. Orthologous to human GNPDA2 (glucosamine-6-phosphate deaminase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 5.6), testis adult (RPKM 4.1) and 27 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
5 C3.1; 5 37.13 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (69732344..69749684, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (69574998..69592332, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4760 Neighboring gene STARR-seq mESC enhancer starr_13339 Neighboring gene Yip1 domain family, member 7 Neighboring gene GUF1 homolog, GTPase Neighboring gene predicted gene, 26044 Neighboring gene predicted gene, 23661

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Two mammalian glucosamine-6-phosphate deaminases: a structural and genetic study. Arreola R, et al. FEBS Lett, 2003 Sep 11. PMID 12965206
  2. Transcriptome Analysis of Targeted Mouse Mutations Reveals the Topography of Local Changes in Gene Expression. West DB, et al. PLoS Genet, 2016 Feb. PMID 26839965, Free PMC Article
  3. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • KIAA4008

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables glucosamine-6-phosphate deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glucosamine-6-phosphate deaminase activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
enables glucosamine-6-phosphate deaminase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in N-acetylglucosamine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in N-acetylglucosamine metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in N-acetylneuraminate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in UDP-N-acetylglucosamine biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glucosamine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
glucosamine-6-phosphate isomerase 2
Names
GNPDA 2
glcN6P deaminase 2
oscillin
NP_001033104.1
NP_001334292.1
NP_001346168.1
XP_011239068.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001038015.2 → NP_001033104.1  glucosamine-6-phosphate isomerase 2 isoform 1

    See identical proteins and their annotated locations for NP_001033104.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC109186
    Consensus CDS
    CCDS19324.1
    UniProtKB/Swiss-Prot
    Q3TH02, Q9CRC9, Q9D457
    Related
    ENSMUSP00000031117.7, ENSMUST00000031117.13
    Conserved Domains (1) summary
    PRK00443
    Location:1 → 258
    nagB; glucosamine-6-phosphate deaminase; Provisional

  2. NM_001347363.1 → NP_001334292.1  glucosamine-6-phosphate isomerase 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC109186
    Consensus CDS
    CCDS84888.1
    UniProtKB/Swiss-Prot
    Q9CRC9
    Related
    ENSMUSP00000133490.2, ENSMUST00000173927.8
    Conserved Domains (1) summary
    cl00339
    Location:1 → 251
    SugarP_isomerase; SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ...

  3. NM_001359239.1 → NP_001346168.1  glucosamine-6-phosphate isomerase 2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC109186, AK051596
    Consensus CDS
    CCDS89926.1
    UniProtKB/TrEMBL
    D3YWR1
    Related
    ENSMUSP00000112484.2, ENSMUST00000120789.8
    Conserved Domains (1) summary
    cl00339
    Location:1 → 253
    SugarP_isomerase; Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    69732344..69749684 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011240766.2 → XP_011239068.1  glucosamine-6-phosphate isomerase 2 isoform X1

    Conserved Domains (1) summary
    cl00339
    Location:1 → 139
    SugarP_isomerase; Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_027681.1: Suppressed sequence

    Description
    NM_027681.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CRC9.1 GenPept UniProtKB/Swiss-Prot:Q9CRC9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous