Ncbp2 nuclear cap binding protein subunit 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ncbp2provided by MGI
Official Full Name: nuclear cap binding protein subunit 2provided by MGI
Primary source: MGI:MGI:1915342
See related: Ensembl:ENSMUSG00000022774 AllianceGenome:MGI:1915342
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 20kDa; 5930413E18Rik
Summary: Predicted to enable RNA 7-methylguanosine cap binding activity; mRNA binding activity; and snRNA binding activity. Predicted to be involved in mRNA metabolic process; positive regulation of mRNA 3'-end processing; and regulation of translational initiation. Predicted to act upstream of or within RNA processing; mRNA transport; and regulation of gene expression. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of mRNA cap binding activity complex and nuclear cap binding activity complex. Is expressed in genitourinary system. Orthologous to human NCBP2 (nuclear cap binding protein subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E11.5 (RPKM 49.7), CNS E14 (RPKM 29.8) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 B2; 16 22.4 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (31767364..31777290)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (31948546..31958472)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NCBP2 is not required for cell viability and poly(A) RNA export.
Title: mRNA export through an additional cap-binding complex consisting of NCBP1 and NCBP3.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126658 (e-PCR)
- UniSTS:209205

NoName (e-PCR)
- UniSTS:488771

RH124294 (e-PCR)
- UniSTS:161116

AI839730 (e-PCR)
- UniSTS:165991

AI843301 (e-PCR)
- UniSTS:165992

AA536802 (e-PCR)
- UniSTS:186070

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA 7-methylguanosine cap binding	ISO Inferred from Sequence Orthology more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA cap binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	ISO Inferred from Sequence Orthology more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables snRNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in alternative mRNA splicing, via spliceosome	NAS Non-traceable Author Statement more info	PubMed
involved_in cap-dependent translational initiation	NAS Non-traceable Author Statement more info	PubMed
involved_in histone mRNA metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA 3'-end processing	NAS Non-traceable Author Statement more info	PubMed
involved_in mRNA cis splicing, via spliceosome	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA splicing, via spliceosome	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in miRNA-mediated post-transcriptional gene silencing	NAS Non-traceable Author Statement more info	PubMed
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of transcription elongation by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed
involved_in primary miRNA processing	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within regulation of translation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulatory ncRNA-mediated gene silencing	IEA Inferred from Electronic Annotation more info
involved_in snRNA export from nucleus	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of RNA cap binding complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	NAS Non-traceable Author Statement more info	PubMed
part_of nuclear cap binding complex	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear cap binding complex	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nuclear cap-binding protein subunit 2

Names: 20 kDa nuclear cap-binding protein; CBP20; NCBP 20 kDa subunit; nuclear cap binding protein subunit 2, 20kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.