U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Slbp stem-loop histone mRNA binding protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 681062, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Slbpprovided by RGD
Official Full Name
stem-loop histone mRNA binding proteinprovided by RGD
Primary source
RGD:1584682
See related
Ensembl:ENSRNOG00000037162 AllianceGenome:RGD:1584682
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable histone pre-mRNA stem-loop binding activity; identical protein binding activity; and mRNA binding activity. Predicted to be involved in mRNA 3'-end processing by stem-loop binding activity and cleavage and mRNA transport. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be part of histone pre-mRNA 3'end processing complex. Predicted to be active in cytoplasm. Orthologous to human SLBP (stem-loop binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 481.9), Spleen (RPKM 437.1) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Slbp in Genome Data Viewer
Location:
14q21
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (81295479..81306446)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (77071441..77081911)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (82356916..82366368)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA18 Neighboring gene transforming, acidic coiled-coil containing protein 3 Neighboring gene transmembrane protein 129, E3 ubiquitin ligase Neighboring gene family with sequence similarity 53, member A Neighboring gene proteasome 20S subunit beta 3, pseudogene 5

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Knockdown of SLBP results in nuclear retention of histone mRNA. Sullivan KD, et al. RNA, 2009 Mar. PMID 19155325, Free PMC Article
  2. SLBP is associated with histone mRNA on polyribosomes as a component of the histone mRNP. Whitfield ML, et al. Nucleic Acids Res, 2004. PMID 15358832, Free PMC Article
  3. Nuclear import of the stem-loop binding protein and localization during the cell cycle. Erkmann JA, et al. Mol Biol Cell, 2005 Jun. PMID 15829567, Free PMC Article
  4. Characterization of 3'hExo, a 3' exonuclease specifically interacting with the 3' end of histone mRNA. Yang XC, et al. J Biol Chem, 2006 Oct 13. PMID 16912046
  5. Assembly of the SLIP1-SLBP complex on histone mRNA requires heterodimerization and sequential binding of SLBP followed by SLIP1. Bansal N, et al. Biochemistry, 2013 Jan 22. PMID 23286197, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC187387

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables histone pre-mRNA stem-loop binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone pre-mRNA stem-loop binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cap-dependent translational initiation ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA 3'-end processing by stem-loop binding and cleavage IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA 3'-end processing by stem-loop binding and cleavage ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of histone mRNA stem-loop binding complex ISO
Inferred from Sequence Orthology
more info
  
part_of histone pre-mRNA 3'end processing complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of histone pre-mRNA 3'end processing complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
histone RNA hairpin-binding protein
Names
stem-loop binding protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130988.1 → NP_001124460.1  histone RNA hairpin-binding protein

    See identical proteins and their annotated locations for NP_001124460.1

    Status: PROVISIONAL

    Source sequence(s)
    BC167755
    UniProtKB/TrEMBL
    A0A8I6AID5, A0A9K3Y6R4, A6IK58, B3DM97, D3ZSM2
    Related
    ENSRNOP00000047799.3, ENSRNOT00000040229.4
    Conserved Domains (1) summary
    pfam15247
    Location:130 → 197
    SLBP_RNA_bind; Histone RNA hairpin-binding protein RNA-binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    81295479..81306446
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039092440.2 → XP_038948368.1  histone RNA hairpin-binding protein isoform X1

    UniProtKB/TrEMBL
    A0A8I6AID5, A6IK58, A6IK59
    Conserved Domains (1) summary
    pfam15247
    Location:95 → 163
    SLBP_RNA_bind; Histone RNA hairpin-binding protein RNA-binding domain
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous