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Steap3 STEAP family member 3 [ Mus musculus (house mouse) ]

Gene ID: 68428, updated on 5-Mar-2024

Summary

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Official Symbol
Steap3provided by MGI
Official Full Name
STEAP family member 3provided by MGI
Primary source
MGI:MGI:1915678
See related
Ensembl:ENSMUSG00000026389 AllianceGenome:MGI:1915678
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tsap6; pHyde; 1010001D01Rik
Summary
Enables cupric reductase activity and ferric-chelate reductase (NADPH) activity. Acts upstream of or within exosomal secretion; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; and transition metal ion transport. Located in endosome and plasma membrane. Is expressed in several structures, including bone; genitourinary system; liver; nervous system; and white fat. Orthologous to human STEAP3 (STEAP3 metalloreductase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in subcutaneous fat pad adult (RPKM 51.4), mammary gland adult (RPKM 39.1) and 19 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 E2.3; 1 52.66 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (120154137..120198810, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (120226414..120271081, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10029 Neighboring gene predicted gene, 41938 Neighboring gene RIKEN cDNA 3110009E18 gene Neighboring gene STARR-positive B cell enhancer ABC_E4342 Neighboring gene STARR-positive B cell enhancer mm9_chr1:122050580-122050881 Neighboring gene diazepam binding inhibitor Neighboring gene STARR-positive B cell enhancer mm9_chr1:122093817-122094118 Neighboring gene STARR-seq mESC enhancer starr_02054 Neighboring gene STARR-seq mESC enhancer starr_02055 Neighboring gene predicted gene, 53581 Neighboring gene STARR-seq mESC enhancer starr_02056 Neighboring gene STARR-seq mESC enhancer starr_02057 Neighboring gene complement component 1, q subcomponent-like 2 Neighboring gene predicted gene, 46154

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. STEAP3 (Six-Transmembrane Epithelial Antigen of Prostate 3) Inhibits Pathological Cardiac Hypertrophy. Li PL, et al. Hypertension, 2020 Oct. PMID 32862709
  2. Abnormal erythroid maturation leads to microcytic anemia in the TSAP6/Steap3 null mouse model. Blanc L, et al. Am J Hematol, 2015 Mar. PMID 25515317, Free PMC Article
  3. Metalloreductase Steap3 coordinates the regulation of iron homeostasis and inflammatory responses. Zhang F, et al. Haematologica, 2012 Dec. PMID 22689674, Free PMC Article
  4. Six-Transmembrane Epithelial Antigen of the Prostate 3 Deficiency in Hepatocytes Protects the Liver Against Ischemia-Reperfusion Injury by Suppressing Transforming Growth Factor-β-Activated Kinase 1. Guo WZ, et al. Hepatology, 2020 Mar. PMID 31393024, Free PMC Article
  5. Differences in Steap3 expression are a mechanism of genetic variation of RBC storage and oxidative damage in mice. Howie HL, et al. Blood Adv, 2019 Aug 13. PMID 31350307, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. STEAP3 (Six-Transmembrane Epithelial Antigen of Prostate 3) Inhibits Pathological Cardiac Hypertrophy.
    Title: STEAP3 (Six-Transmembrane Epithelial Antigen of Prostate 3) Inhibits Pathological Cardiac Hypertrophy.
  2. Six-Transmembrane Epithelial Antigen of the Prostate 3 Deficiency in Hepatocytes Protects the Liver Against Ischemia-Reperfusion Injury by Suppressing Transforming Growth Factor-beta-Activated Kinase 1.
    Title: Six-Transmembrane Epithelial Antigen of the Prostate 3 Deficiency in Hepatocytes Protects the Liver Against Ischemia-Reperfusion Injury by Suppressing Transforming Growth Factor-β-Activated Kinase 1.
  3. TSAP6 deficiency results in abnormal erythroid maturation and leads to microcytic anemia.
    Title: Abnormal erythroid maturation leads to microcytic anemia in the TSAP6/Steap3 null mouse model.
  4. Steap3 deficiency causes abnormal iron status and homeostasis, which leads to impaired TLR4-mediated inflammatory responses in macrophages.
    Title: Metalloreductase Steap3 coordinates the regulation of iron homeostasis and inflammatory responses.
  5. Data show that the STEAP3/TSAP6 is absent in the mouse embryo fibroblasts derived from the STEAP3/TSAP6 knock-out mice (MEFs KO), but present in the wild type MEFs.
    Title: A novel type of congenital hypochromic anemia associated with a nonsense mutation in the STEAP3/TSAP6 gene.
  6. hypochromic microcytic anemia results from a Y228H substitution in the ferrireductase Steap3 (Steap3(Y288H))
    Title: Identification of a Steap3 endosomal targeting motif essential for normal iron metabolism.
  7. The DNA damage-induced p53-dependent nonclassical exosomal secretory pathway is abrogated in TSAP6-null cells.
    Title: Exosome secretion, including the DNA damage-induced p53-dependent secretory pathway, is severely compromised in TSAP6/Steap3-null mice.
  8. TSAP6 may augment Myt1 activity and act downstream to p53 to interface apoptosis and cell-cycle progression
    Title: The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Targeted (5)  1 citation
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables FAD binding ISO
Inferred from Sequence Orthology
more info
  
enables cupric reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cupric reductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ferric-chelate reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ferric-chelate reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ferric-chelate reductase (NADPH) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ferric-chelate reductase (NADPH) activity ISO
Inferred from Sequence Orthology
more info
  
enables ferric-chelate reductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ferric-chelate reductase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables heme binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in copper ion import IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within copper ion import IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within copper ion import IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within exosomal secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within iron import into cell IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within iron ion import across cell outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within iron ion import across cell outer membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within iron ion transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein secretion ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in protein secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in protein secretion ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in multivesicular body ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
metalloreductase STEAP3
Names
dudulin 2
protein nm1054
six-transmembrane epithelial antigen of prostate 3
tumor suppressor-activated pathway protein 6
NP_001078878.1
NP_001366283.1
NP_001366284.1
NP_573449.2
XP_006529908.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001085409.2 → NP_001078878.1  metalloreductase STEAP3 isoform b

    See identical proteins and their annotated locations for NP_001078878.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 all encode the same isoform (b).
    Source sequence(s)
    AC084310, AC139867
    Consensus CDS
    CCDS48343.1
    UniProtKB/Swiss-Prot
    Q3TKE4, Q80ZF3, Q8C5F0, Q8CI59, Q924Z1
    UniProtKB/TrEMBL
    A0A0R4J1G9
    Related
    ENSMUSP00000108260.2, ENSMUST00000112641.8
    Conserved Domains (2) summary
    COG2085
    Location:29 → 209
    COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
    pfam01794
    Location:262 → 405
    Ferric_reduct; Ferric reductase like transmembrane component

  2. NM_001379354.1 → NP_001366283.1  metalloreductase STEAP3 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), as well as variants 1 and 2, encodes isoform b.
    Source sequence(s)
    AC084310, AC139867
    UniProtKB/Swiss-Prot
    Q3TKE4, Q80ZF3, Q8C5F0, Q8CI59, Q924Z1
    UniProtKB/TrEMBL
    A0A0R4J1G9
    Related
    ENSMUSP00000108258.2, ENSMUST00000112639.8
    Conserved Domains (2) summary
    COG2085
    Location:29 → 209
    COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
    pfam01794
    Location:262 → 405
    Ferric_reduct; Ferric reductase like transmembrane component

  3. NM_001379355.1 → NP_001366284.1  metalloreductase STEAP3 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) encodes the longer isoform (a).
    Source sequence(s)
    AC084310, AC139867
    UniProtKB/Swiss-Prot
    Q3TKE4, Q80ZF3, Q8C5F0, Q8CI59, Q924Z1
    Conserved Domains (2) summary
    COG2085
    Location:39 → 219
    COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
    pfam01794
    Location:272 → 415
    Ferric_reduct; Ferric reductase like transmembrane component

  4. NM_133186.4 → NP_573449.2  metalloreductase STEAP3 isoform b

    See identical proteins and their annotated locations for NP_573449.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-3 all encode the same isoform (b).
    Source sequence(s)
    AC084310, AC139867
    Consensus CDS
    CCDS48343.1
    UniProtKB/Swiss-Prot
    Q3TKE4, Q80ZF3, Q8C5F0, Q8CI59, Q924Z1
    UniProtKB/TrEMBL
    A0A0R4J1G9
    Related
    ENSMUSP00000108259.2, ENSMUST00000112640.8
    Conserved Domains (2) summary
    COG2085
    Location:29 → 209
    COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
    pfam01794
    Location:262 → 405
    Ferric_reduct; Ferric reductase like transmembrane component

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    120154137..120198810 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529845.4 → XP_006529908.1  metalloreductase STEAP3 isoform X1

    UniProtKB/Swiss-Prot
    Q3TKE4, Q80ZF3, Q8C5F0, Q8CI59, Q924Z1
    UniProtKB/TrEMBL
    E9QN92
    Related
    ENSMUSP00000108262.2, ENSMUST00000112643.2
    Conserved Domains (2) summary
    COG2085
    Location:67 → 247
    COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
    pfam01794
    Location:300 → 443
    Ferric_reduct; Ferric reductase like transmembrane component
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CI59.1 GenPept UniProtKB/Swiss-Prot:Q8CI59

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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