U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Wdr73 WD repeat domain 73 [ Mus musculus (house mouse) ]

Gene ID: 71968, updated on 30-Apr-2024

Summary

Official Symbol
Wdr73provided by MGI
Official Full Name
WD repeat domain 73provided by MGI
Primary source
MGI:MGI:1919218
See related
Ensembl:ENSMUSG00000025722 AllianceGenome:MGI:1919218
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1200011I23Rik; 2410008B13Rik
Summary
Predicted to be involved in cytoplasmic microtubule organization; negative regulation of apoptotic process; and nucleus organization. Predicted to be located in cytoplasm and cytoskeleton. Predicted to colocalize with cleavage furrow; cytosol; and spindle pole. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome 1. Orthologous to human WDR73 (WD repeat domain 73). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 7.9), whole brain E14.5 (RPKM 7.6) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Wdr73 in Genome Data Viewer
Location:
7 D3; 7 45.71 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (80540471..80551017, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (80890723..80901269, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene IQ motif containing GTPase activating protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E6567 Neighboring gene predicted gene, 18392 Neighboring gene STARR-seq mESC enhancer starr_19336 Neighboring gene VISTA enhancer mm170 Neighboring gene STARR-positive B cell enhancer ABC_E10447 Neighboring gene STARR-seq mESC enhancer starr_19340 Neighboring gene STARR-positive B cell enhancer ABC_E11358 Neighboring gene STARR-seq mESC enhancer starr_19343 Neighboring gene STARR-positive B cell enhancer ABC_E552 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:88009760-88009913 Neighboring gene zinc finger and SCAN domain containing 2 Neighboring gene predicted gene, 32112 Neighboring gene predicted gene, 51451 Neighboring gene neuromedin B Neighboring gene SEC11 homolog A, signal peptidase complex subunit

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in cytoplasmic microtubule organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cytoplasmic microtubule organization ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in nucleus organization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
colocalizes_with cleavage furrow ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
colocalizes_with cytosol ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
 
colocalizes_with spindle pole ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
WD repeat-containing protein 73

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028026.2NP_082302.2  WD repeat-containing protein 73

    See identical proteins and their annotated locations for NP_082302.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the functional protein.
    Source sequence(s)
    AK010448, AK169377, AK169527, BM940898
    Consensus CDS
    CCDS52282.1
    UniProtKB/Swiss-Prot
    Q05C70, Q3TEN7, Q571I2, Q8BSB9, Q8CF62, Q9CWR1
    Related
    ENSMUSP00000026816.9, ENSMUST00000026816.15
    Conserved Domains (3) summary
    COG2319
    Location:238364
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:279322
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:238364
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. NR_027976.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC123744, AK169377, BC068122
    Related
    ENSMUST00000139990.8
  2. NR_152100.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has multiple differences at the 5' end, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC123744
  3. NR_152101.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks a 5' exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC123744

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    80540471..80551017 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153449.1XP_036009342.1  WD repeat-containing protein 73 isoform X1

    Conserved Domains (2) summary
    COG2319
    Location:129255
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:170213
    7WD40; WD40 repeat [structural motif]
  2. XM_036153447.1XP_036009340.1  WD repeat-containing protein 73 isoform X1

    Conserved Domains (2) summary
    COG2319
    Location:129255
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:170213
    7WD40; WD40 repeat [structural motif]
  3. XM_036153448.1XP_036009341.1  WD repeat-containing protein 73 isoform X1

    Conserved Domains (2) summary
    COG2319
    Location:129255
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:170213
    7WD40; WD40 repeat [structural motif]
  4. XM_006541206.1XP_006541269.1  WD repeat-containing protein 73 isoform X1

    See identical proteins and their annotated locations for XP_006541269.1

    UniProtKB/Swiss-Prot
    Q9CWR1
    Conserved Domains (2) summary
    COG2319
    Location:129255
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:170213
    7WD40; WD40 repeat [structural motif]
  5. XM_006541209.1XP_006541272.1  WD repeat-containing protein 73 isoform X1

    See identical proteins and their annotated locations for XP_006541272.1

    UniProtKB/Swiss-Prot
    Q9CWR1
    Conserved Domains (2) summary
    COG2319
    Location:129255
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:170213
    7WD40; WD40 repeat [structural motif]