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PHATRDRAFT_44618 2-isopropylmalate synthase [ Phaeodactylum tricornutum CCAP 1055/1 ]

Gene ID: 7197622, updated on 11-Apr-2024

Summary

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Gene symbol
PHATRDRAFT_44618
Gene description
2-isopropylmalate synthase
Locus tag
PHATRDRAFT_44618
Gene type
protein coding
RNA name
2-isopropylmalate synthase
RefSeq status
PROVISIONAL
Organism
Phaeodactylum tricornutum CCAP 1055/1 (strain: CCAP 1055/1)
Lineage
Eukaryota; Stramenopiles; Bacillariophyta; Bacillariophyceae; Bacillariophycidae; Naviculales; Phaeodactylaceae; Phaeodactylum
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Genomic context

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Location:
chromosome: 4
Exon count:
1
Sequence:
Chromosome: 4; NC_011672.1 (1065041..1067184, complement)

Chromosome 4 - NC_011672.1Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_011672.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Phaeodactylum genome reveals the evolutionary history of diatom genomes. Bowler C, et al. Nature, 2008 Nov 13. PMID 18923393

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 2-isopropylmalate synthase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in L-leucine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Names
2-isopropylmalate synthase
XP_002178632.1
  • [FUNCTION] Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate). [CATALYTIC ACTIVITY] Acetyl-CoA + 3-methyl-2-oxobutanoate + H(2)O = (2S)-2-isopropylmalate + CoA. [PATHWAY] Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1. [SUBUNIT] Homotetramer (By similarity). [SIMILARITY] Belongs to the alpha-IPM synthetase/homocitrate synthase family. LeuA type 1 subfamily.

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_011672.1 Reference assembly

    Range
    1065041..1067184 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_002178596.1 → XP_002178632.1  2-isopropylmalate synthase [Phaeodactylum tricornutum CCAP 1055/1]

    See identical proteins and their annotated locations for XP_002178632.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8J9SG73, B7FUP6
    Conserved Domains (1) summary
    PLN02321
    Location:4 → 648
    PLN02321; 2-isopropylmalate synthase
Nucleotide Protein
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