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TXK TXK tyrosine kinase [ Homo sapiens (human) ]

Gene ID: 7294, updated on 11-Apr-2024

Summary

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Official Symbol
TXKprovided by HGNC
Official Full Name
TXK tyrosine kinaseprovided by HGNC
Primary source
HGNC:HGNC:12434
See related
Ensembl:ENSG00000074966 MIM:600058; AllianceGenome:HGNC:12434
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RLK; TKL; BTKL; PTK4; PSCTK5
Summary
Predicted to enable non-membrane spanning protein tyrosine kinase activity. Involved in positive regulation of interferon-gamma-mediated signaling pathway; positive regulation of macromolecule metabolic process; and protein autophosphorylation. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lymph node (RPKM 5.7), spleen (RPKM 3.3) and 15 other tissues See more
Orthologs
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Genomic context

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Location:
4p12
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (48066393..48134250, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (48033459..48101082, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (48068410..48136267, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927157 Neighboring gene cyclic nucleotide gated channel subunit alpha 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:48013506-48014020 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:48014021-48014534 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:48018379-48018880 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15402 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15403 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21533 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21534 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21535 Neighboring gene NIPA like domain containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21536 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:48095793-48096992 Neighboring gene uncharacterized LOC124900886 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:48114113-48115312 Neighboring gene RNA, U6 small nuclear 838, pseudogene Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:48129156-48130018 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21537 Neighboring gene Sharpr-MPRA regulatory region 15119 Neighboring gene NANOG hESC enhancer GRCh37_chr4:48177274-48177775 Neighboring gene tec protein tyrosine kinase Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:48187797-48188522 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21538 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21539 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21540 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21541 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21542 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21543 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21544 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21545 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21546 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21547 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15404 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15405 Neighboring gene uncharacterized LOC105374445 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:48293363-48294358

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Skewed Th1 responses caused by excessive expression of Txk, a member of the Tec family of tyrosine kinases, in patients with Behcet's disease. Suzuki N, et al. Clin Med Res, 2006 Jun. PMID 16809408, Free PMC Article
  2. TXK, a novel human tyrosine kinase expressed in T cells shares sequence identity with Tec family kinases and maps to 4p12. Haire RN, et al. Hum Mol Genet, 1994 Jun. PMID 7951233
  3. Targeting interleukin-2-inducible T-cell kinase (ITK) and resting lymphocyte kinase (RLK) using a novel covalent inhibitor PRN694. Zhong Y, et al. J Biol Chem, 2015 Mar 6. PMID 25593320, Free PMC Article
  4. Evidence of autophosphorylation in Txk: Y91 is an autophosphorylation site. Kashiwakura J, et al. Biol Pharm Bull, 2002 Jun. PMID 12081135
  5. Txk, a nonreceptor tyrosine kinase of the Tec family, is expressed in T helper type 1 cells and regulates interferon gamma production in human T lymphocytes. Kashiwakura J, et al. J Exp Med, 1999 Oct 18. PMID 10523612, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These data indicate that PRN694 is a highly selective and potent covalent inhibitor of ITK and RLK, and its extended target residence time enables durable attenuation of effector cells in vitro and in vivo.
    Title: Targeting interleukin-2-inducible T-cell kinase (ITK) and resting lymphocyte kinase (RLK) using a novel covalent inhibitor PRN694.
  2. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  3. Observational study of gene-disease association. (HuGE Navigator)
    Title: Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.
  4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  5. Itk and Txk exert their effects on T helper (Th) cell differentiation and function at the level of expression; transgenic Txk is not a specific regulator of Th1 responses.
    Title: Selective expression rather than specific function of Txk and Itk regulate Th1 and Th2 responses.
  6. Th1 cells expressing Txk and Th1-associated cytokines may play a critical role in the development of skin and intestinal lesions in patients with Behcet's disease.
    Title: Skewed Th1 responses caused by excessive expression of Txk, a member of the Tec family of tyrosine kinases, in patients with Behcet's disease.
  7. fuctions as a Th1 cell-specific transcription factor and regulates IFN-gamma gene transcription
    Title: Txk, a member of nonreceptor tyrosine kinase of Tec family, acts as a Th1 cell-specific transcription factor and regulates IFN-gamma gene transcription.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC22473

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in T cell receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in activation of phospholipase C activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in adaptive immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adaptive immune response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of cytokine production ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of type II interferon production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of type II interferon-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
tyrosine-protein kinase TXK
Names
PTK4 protein tyrosine kinase 4
protein-tyrosine kinase 4
resting lymphocyte kinase
NP_003319.2
XP_011512049.1
XP_011512050.1
XP_016864070.1
XP_024309968.1
XP_047272078.1
XP_047272079.1
XP_047272081.1
XP_054206748.1
XP_054206749.1
XP_054206750.1
XP_054206751.1
XP_054206752.1
XP_054206753.1
XP_054206754.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003328.3 → NP_003319.2  tyrosine-protein kinase TXK

    See identical proteins and their annotated locations for NP_003319.2

    Status: VALIDATED

    Source sequence(s)
    AC096749, DB103575, L27071
    Consensus CDS
    CCDS3480.1
    UniProtKB/Swiss-Prot
    P42681, Q14220
    UniProtKB/TrEMBL
    E7EQN8
    Related
    ENSP00000264316.4, ENST00000264316.9
    Conserved Domains (3) summary
    cd05059
    Location:266 → 521
    PTKc_Tec_like; Catalytic domain of Tec-like Protein Tyrosine Kinases
    cd10398
    Location:143 → 248
    SH2_Tec_Txk; Src homology 2 (SH2) domain found in Tec protein, Txk
    cd11907
    Location:85 → 139
    SH3_TXK; Src Homology 3 domain of TXK, also called Resting lymphocyte kinase (Rlk)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    48066393..48134250 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008581.3 → XP_016864070.1  tyrosine-protein kinase TXK isoform X3

    UniProtKB/TrEMBL
    E7EQN8

  2. XM_011513747.4 → XP_011512049.1  tyrosine-protein kinase TXK isoform X2

    UniProtKB/TrEMBL
    E7EQN8
    Conserved Domains (4) summary
    cd05059
    Location:247 → 502
    PTKc_Tec_like; Catalytic domain of Tec-like Protein Tyrosine Kinases
    cd10398
    Location:131 → 229
    SH2_Tec_Txk; Src homology 2 (SH2) domain found in Tec protein, Txk
    pfam07714
    Location:252 → 499
    Pkinase_Tyr; Protein tyrosine kinase
    cl17036
    Location:88 → 130
    SH3; Src Homology 3 domain superfamily

  3. XM_024454200.2 → XP_024309968.1  tyrosine-protein kinase TXK isoform X1

    UniProtKB/TrEMBL
    E7EQN8
    Conserved Domains (3) summary
    cd05059
    Location:269 → 524
    PTKc_Tec_like; Catalytic domain of Tec-like Protein Tyrosine Kinases
    cd10398
    Location:146 → 251
    SH2_Tec_Txk; Src homology 2 (SH2) domain found in Tec protein, Txk
    cd11907
    Location:88 → 142
    SH3_TXK; Src Homology 3 domain of TXK, also called Resting lymphocyte kinase (Rlk)

  4. XM_047416123.1 → XP_047272079.1  tyrosine-protein kinase TXK isoform X5

  5. XM_011513748.4 → XP_011512050.1  tyrosine-protein kinase TXK isoform X6

    Conserved Domains (2) summary
    pfam07714
    Location:33 → 280
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:28 → 287
    PKc_like; Protein Kinases, catalytic domain

  6. XM_047416122.1 → XP_047272078.1  tyrosine-protein kinase TXK isoform X4

  7. XM_047416125.1 → XP_047272081.1  tyrosine-protein kinase TXK isoform X7

RNA

  1. XR_007057955.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    48033459..48101082 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054350775.1 → XP_054206750.1  tyrosine-protein kinase TXK isoform X3

  2. XM_054350774.1 → XP_054206749.1  tyrosine-protein kinase TXK isoform X2

  3. XM_054350773.1 → XP_054206748.1  tyrosine-protein kinase TXK isoform X1

  4. XM_054350777.1 → XP_054206752.1  tyrosine-protein kinase TXK isoform X5

  5. XM_054350778.1 → XP_054206753.1  tyrosine-protein kinase TXK isoform X6

  6. XM_054350776.1 → XP_054206751.1  tyrosine-protein kinase TXK isoform X4

  7. XM_054350779.1 → XP_054206754.1  tyrosine-protein kinase TXK isoform X7

RNA

  1. XR_008487028.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P42681.3 GenPept UniProtKB/Swiss-Prot:P42681

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