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UBE2B ubiquitin conjugating enzyme E2 B [ Homo sapiens (human) ]

Gene ID: 7320, updated on 4-Jan-2025

Summary

Official Symbol
UBE2Bprovided by HGNC
Official Full Name
ubiquitin conjugating enzyme E2 Bprovided by HGNC
Primary source
HGNC:HGNC:12473
See related
Ensembl:ENSG00000119048 MIM:179095; AllianceGenome:HGNC:12473
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HR6B; UBC2; HHR6B; RAD6B; E2-17kDa
Summary
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in adrenal (RPKM 31.0), heart (RPKM 26.8) and 25 other tissues See more
Orthologs
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Genomic context

See UBE2B in Genome Data Viewer
Location:
5q31.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (134371569..134392108)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (134895355..134915908)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (133707260..133727799)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:133562023-133562544 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:133562545-133563064 Neighboring gene PPP2CA divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23141 Neighboring gene ribosomal protein S13 pseudogene 6 Neighboring gene MPRA-validated peak5475 silencer Neighboring gene cyclin dependent kinase like 3 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:133680746-133681444 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:133681445-133682144 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:133706379-133706974 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16357 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23143 Neighboring gene CDKN2A interacting protein N-terminal like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:133746964-133747702 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:133747703-133748440 Neighboring gene ribosomal protein S10 pseudogene 11

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of ubiquitin-conjugating enzyme E2B (UBE2B) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Items 1 - 25 of 33
Process Evidence Code Pubs
involved_in DNA damage response PubMed 
involved_in DNA repair  
involved_in DNA repair PubMed 
involved_in apoptotic process  
involved_in chiasma assembly  
involved_in chromatin organization  
involved_in ectopic germ cell programmed cell death  
involved_in in utero embryonic development  
involved_in meiotic telomere clustering  
involved_in negative regulation of apoptotic process  
involved_in negative regulation of developmental process  
involved_in negative regulation of post-translational protein modification  
involved_in negative regulation of reproductive process  
involved_in positive regulation of canonical Wnt signaling pathway  
involved_in positive regulation of reciprocal meiotic recombination  
involved_in postreplication repair PubMed 
involved_in postreplication repair PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process PubMed 
involved_in protein K11-linked ubiquitination PubMed 
involved_in protein K48-linked ubiquitination PubMed 
involved_in protein K63-linked ubiquitination PubMed 
involved_in protein autoubiquitination PubMed 
involved_in protein polyubiquitination  
involved_in protein stabilization PubMed 
involved_in protein ubiquitination PubMed 
involved_in response to UV PubMed 
involved_in response to xenobiotic stimulus PubMed 
involved_in sperm axoneme assembly  
involved_in spermatogenesis PubMed 
involved_in synaptonemal complex organization  
involved_in ubiquitin-dependent protein catabolic process PubMed 
involved_in ubiquitin-dependent protein catabolic process PubMed 
Items 1 - 25 of 33
Component Evidence Code Pubs
part_of HULC complex  
part_of HULC complex PubMed 
located_in XY body  
located_in chromatin  
located_in cytoplasm PubMed 
located_in nucleoplasm  
located_in nucleus PubMed 
located_in plasma membrane  
located_in replication fork PubMed 

General protein information

Preferred Names
ubiquitin-conjugating enzyme E2 B
Names
E2 protein
E2 ubiquitin-conjugating enzyme B
RAD6 homolog B
ubiquitin carrier protein B
ubiquitin conjugating enzyme E2B
ubiquitin-conjugating enzyme E2-17 kDa
ubiquitin-conjugating enzyme E2B (RAD6 homolog)
ubiquitin-protein ligase B
NP_003328.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046936.1 RefSeqGene

    Range
    5394..25933
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003337.4NP_003328.1  ubiquitin-conjugating enzyme E2 B

    See identical proteins and their annotated locations for NP_003328.1

    Status: REVIEWED

    Source sequence(s)
    AK312012, BU954901, M74525, T88933
    Consensus CDS
    CCDS4174.1
    UniProtKB/Swiss-Prot
    B2R503, D3DQA2, P23567, P63146, Q4PJ15, Q9D0J6
    UniProtKB/TrEMBL
    Q53G86
    Related
    ENSP00000265339.2, ENST00000265339.7
    Conserved Domains (1) summary
    pfam00179
    Location:8145
    UQ_con; Ubiquitin-conjugating enzyme

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    134371569..134392108
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    134895355..134915908
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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