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Nmnat3 nicotinamide nucleotide adenylyltransferase 3 [ Mus musculus (house mouse) ]

Gene ID: 74080, updated on 28-Apr-2024

Summary

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Official Symbol
Nmnat3provided by MGI
Official Full Name
nicotinamide nucleotide adenylyltransferase 3provided by MGI
Primary source
MGI:MGI:1921330
See related
Ensembl:ENSMUSG00000032456 AllianceGenome:MGI:1921330
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PNAT3; 4933408N02Rik
Summary
Enables nicotinamide-nucleotide adenylyltransferase activity. Acts upstream of or within NAD biosynthetic process and response to wounding. Located in mitochondrion. Is expressed in several structures, including alimentary system; hemolymphoid system; liver; and urinary system. Orthologous to human NMNAT3 (nicotinamide nucleotide adenylyltransferase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14.5 (RPKM 10.3), liver E14 (RPKM 9.0) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 E3.3; 9 51.35 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (98169487..98302586)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (98287433..98420533)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24994 Neighboring gene predicted gene, 25607 Neighboring gene calsyntenin 2 Neighboring gene STARR-seq mESC enhancer starr_24995 Neighboring gene STARR-seq mESC enhancer starr_24997 Neighboring gene RIKEN cDNA 4921534H16 gene Neighboring gene STARR-seq mESC enhancer starr_25001 Neighboring gene STARR-positive B cell enhancer ABC_E6795 Neighboring gene STARR-positive B cell enhancer ABC_E10579 Neighboring gene predicted gene, 46126 Neighboring gene predicted gene 28530 Neighboring gene retinol binding protein 1, cellular Neighboring gene retinol binding protein 2, cellular

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Nmnat3 deficiency in hemolytic anemia exacerbates malaria infection. Mahmood A, et al. Biochem Biophys Res Commun, 2022 Dec 31. PMID 36375251
  2. Overexpression of Nmnat3 efficiently increases NAD and NGD levels and ameliorates age-associated insulin resistance. Gulshan M, et al. Aging Cell, 2018 Aug. PMID 29901258, Free PMC Article
  3. Nmnat3 Is Dispensable in Mitochondrial NAD Level Maintenance In Vivo. Yamamoto M, et al. PLoS One, 2016. PMID 26756334, Free PMC Article
  4. Metabolism and biochemical properties of nicotinamide adenine dinucleotide (NAD) analogs, nicotinamide guanine dinucleotide (NGD) and nicotinamide hypoxanthine dinucleotide (NHD). Yaku K, et al. Sci Rep, 2019 Sep 11. PMID 31511627, Free PMC Article
  5. Nicotinamide mononucleotide adenylyltransferase expression in mitochondrial matrix delays Wallerian degeneration. Yahata N, et al. J Neurosci, 2009 May 13. PMID 19439605, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The results suggest that Nmnat3 overexpression improves metabolic health and that Nmnat3 is an attractive therapeutic target for metabolic disorders that are caused by aging.
    Title: Overexpression of Nmnat3 efficiently increases NAD and NGD levels and ameliorates age-associated insulin resistance.
  2. NMNAT3 regulates the activity of SIRT3 via synthesis of mitochondria NAD.
    Title: NMNAT3 is involved in the protective effect of SIRT3 in Ang II-induced cardiac hypertrophy.
  3. Results indicated that Nmnat3 is dispensable in the maintenance of mitochondrial NAD levels, and that other NAD regulatory pathways may exist in mitochondria.
    Title: Nmnat3 Is Dispensable in Mitochondrial NAD Level Maintenance In Vivo.
  4. Data indicate that nicotinamide mononucleotide adenylyltransferase 3 (Nmnat3)deficiency causes splenomegaly and hemolytic anemia in mice.
    Title: Deficiency of nicotinamide mononucleotide adenylyltransferase 3 (nmnat3) causes hemolytic anemia by altering the glycolytic flow in mature erythrocytes.
  5. results suggest that axonal protection by NMNAT expression in neurons is provided by modifying mitochondrial functionNMNAT activity does lead to axonal protection phenotype in vivo
    Title: Nicotinamide mononucleotide adenylyltransferase expression in mitochondrial matrix delays Wallerian degeneration.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1)  1 citation
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC102340

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables nicotinamide-nucleotide adenylyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nicotinamide-nucleotide adenylyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nicotinate-nucleotide adenylyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nicotinate-nucleotide adenylyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in NAD biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within NAD biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within pyridine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to wounding IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3
Names
NMN adenylyltransferase 3
NMN/NaMN adenylyltransferase 3
naMN adenylyltransferase 1
naMN adenylyltransferase 3
nicotinamide mononucleotide adenylyltransferase 3
nicotinate-nucleotide adenylyltransferase 1
nicotinate-nucleotide adenylyltransferase 3
NP_001344374.1
NP_001344375.1
NP_001344378.1
NP_001344380.1
NP_001344381.1
NP_653116.1
XP_006511565.1
XP_006511566.1
XP_006511567.1
XP_011241128.1
XP_011241129.1
XP_030100520.1
XP_036011241.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357445.1 → NP_001344374.1  nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AC121597, AC144809, AK041897
    Consensus CDS
    CCDS90647.1
    UniProtKB/TrEMBL
    Q3V3C7
    Related
    ENSMUSP00000108559.2, ENSMUST00000112937.3
    Conserved Domains (1) summary
    cl00015
    Location:1 → 166
    nt_trans; nucleotidyl transferase superfamily

  2. NM_001357446.1 → NP_001344375.1  nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AC121597, AC144809, BB661406
    Conserved Domains (1) summary
    cl00015
    Location:17 → 122
    nt_trans; nucleotidyl transferase superfamily

  3. NM_001357449.1 → NP_001344378.1  nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (d) has a shorter and distinct C-terminus compared to isoform a. Variants 4, 5, and 6 all encode the same isoform (d).
    Source sequence(s)
    AC121597, AC144809
    Consensus CDS
    CCDS90646.1
    UniProtKB/TrEMBL
    Q3V3F1
    Conserved Domains (1) summary
    cl00015
    Location:7 → 121
    nt_trans; nucleotidyl transferase superfamily

  4. NM_001357451.1 → NP_001344380.1  nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (d) has a shorter and distinct C-terminus compared to isoform a. Variants 4, 5, and 6 all encode the same isoform (d).
    Source sequence(s)
    AC121597, AC144809, AK041526
    Consensus CDS
    CCDS90646.1
    UniProtKB/TrEMBL
    Q3V3F1
    Related
    ENSMUSP00000108560.2, ENSMUST00000112938.8
    Conserved Domains (1) summary
    cl00015
    Location:7 → 121
    nt_trans; nucleotidyl transferase superfamily

  5. NM_001357452.1 → NP_001344381.1  nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (d) has a shorter and distinct C-terminus compared to isoform a. Variants 4, 5, and 6 all encode the same isoform (d).
    Source sequence(s)
    AC121597, AC144809, BF472005
    Consensus CDS
    CCDS90646.1
    UniProtKB/TrEMBL
    Q3V3F1
    Conserved Domains (1) summary
    cl00015
    Location:7 → 121
    nt_trans; nucleotidyl transferase superfamily

  6. NM_144533.3 → NP_653116.1  nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform a

    See identical proteins and their annotated locations for NP_653116.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC121597, AC144809
    Consensus CDS
    CCDS23423.1
    UniProtKB/Swiss-Prot
    Q58E37, Q99JR6
    Related
    ENSMUSP00000108557.3, ENSMUST00000112935.8
    Conserved Domains (1) summary
    cd09286
    Location:7 → 232
    NMNAT_Eukarya; Nicotinamide/nicotinate mononucleotide adenylyltransferase, Eukaryotic

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    98169487..98302586
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242826.3 → XP_011241128.1  nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform X1

    See identical proteins and their annotated locations for XP_011241128.1

    UniProtKB/Swiss-Prot
    Q58E37, Q99JR6
    Conserved Domains (1) summary
    cd09286
    Location:7 → 232
    NMNAT_Eukarya; Nicotinamide/nicotinate mononucleotide adenylyltransferase, Eukaryotic

  2. XM_011242827.3 → XP_011241129.1  nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform X1

    See identical proteins and their annotated locations for XP_011241129.1

    UniProtKB/Swiss-Prot
    Q58E37, Q99JR6
    Conserved Domains (1) summary
    cd09286
    Location:7 → 232
    NMNAT_Eukarya; Nicotinamide/nicotinate mononucleotide adenylyltransferase, Eukaryotic

  3. XM_036155348.1 → XP_036011241.1  nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform X2

    Conserved Domains (1) summary
    cl00015
    Location:7 → 121
    nt_trans; nucleotidyl transferase superfamily

  4. XM_006511502.4 → XP_006511565.1  nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform X1

    See identical proteins and their annotated locations for XP_006511565.1

    UniProtKB/Swiss-Prot
    Q58E37, Q99JR6
    Conserved Domains (1) summary
    cd09286
    Location:7 → 232
    NMNAT_Eukarya; Nicotinamide/nicotinate mononucleotide adenylyltransferase, Eukaryotic

  5. XM_006511503.4 → XP_006511566.1  nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform X1

    See identical proteins and their annotated locations for XP_006511566.1

    UniProtKB/Swiss-Prot
    Q58E37, Q99JR6
    Conserved Domains (1) summary
    cd09286
    Location:7 → 232
    NMNAT_Eukarya; Nicotinamide/nicotinate mononucleotide adenylyltransferase, Eukaryotic

  6. XM_006511504.4 → XP_006511567.1  nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform X1

    See identical proteins and their annotated locations for XP_006511567.1

    UniProtKB/Swiss-Prot
    Q58E37, Q99JR6
    Conserved Domains (1) summary
    cd09286
    Location:7 → 232
    NMNAT_Eukarya; Nicotinamide/nicotinate mononucleotide adenylyltransferase, Eukaryotic

  7. XM_030244660.2 → XP_030100520.1  nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform X1

    UniProtKB/Swiss-Prot
    Q58E37, Q99JR6
    Conserved Domains (1) summary
    cd09286
    Location:7 → 232
    NMNAT_Eukarya; Nicotinamide/nicotinate mononucleotide adenylyltransferase, Eukaryotic
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99JR6.1 GenPept UniProtKB/Swiss-Prot:Q99JR6

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