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VIP vasoactive intestinal peptide [ Homo sapiens (human) ]

Gene ID: 7432, updated on 4-Jan-2025

Summary

Official Symbol
VIPprovided by HGNC
Official Full Name
vasoactive intestinal peptideprovided by HGNC
Primary source
HGNC:HGNC:12693
See related
Ensembl:ENSG00000146469 MIM:192320; AllianceGenome:HGNC:12693
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PHM27
Summary
The protein encoded by this gene belongs to the glucagon family. It stimulates myocardial contractility, causes vasodilation, increases glycogenolysis, lowers arterial blood pressure and relaxes the smooth muscle of trachea, stomach and gall bladder. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2014]
Expression
Biased expression in appendix (RPKM 33.5), colon (RPKM 12.6) and 3 other tissues See more
Orthologs
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Genomic context

See VIP in Genome Data Viewer
Location:
6q25.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (152750797..152759760)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (153952118..153961081)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (153071932..153080895)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378061 Neighboring gene heat shock protein family D (Hsp60) member 1 pseudogene 16 Neighboring gene MYC target 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr6:153042324-153043523 Neighboring gene long intergenic non-protein coding RNA 2840 Neighboring gene uncharacterized LOC124901440 Neighboring gene uncharacterized LOC124901439 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25290

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env VIP is more potent at suppressing M-tropic than T-tropic HIV-1 gp120 chemotaxis PubMed
env Vasoactive intestinal peptide (VIP) blocks HIV-1 gp120-induced neurotoxicity in culture PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Clone Names

  • MGC13587

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway PubMed 
involved_in antibacterial humoral response PubMed 
involved_in antifungal humoral response PubMed 
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide PubMed 
involved_in body fluid secretion PubMed 
involved_in defense response to Gram-negative bacterium PubMed 
involved_in defense response to Gram-positive bacterium PubMed 
involved_in epinephrine secretion  
involved_in innate immune response PubMed 
involved_in mRNA stabilization  
involved_in positive regulation of cell population proliferation PubMed 
involved_in positive regulation of protein catabolic process PubMed 
involved_in prolactin secretion  
involved_in regulation of protein localization  
involved_in regulation of protein localization PubMed 
involved_in response to yeast PubMed 
Component Evidence Code Pubs
located_in extracellular region  
is_active_in extracellular space PubMed 
is_active_in neuron projection  

General protein information

Preferred Names
VIP peptides
Names
prepro-VIP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003381.4NP_003372.1  VIP peptides isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_003372.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC009794, BM971673, DA914915
    Consensus CDS
    CCDS5240.1
    UniProtKB/Swiss-Prot
    P01282, Q5TCY8, Q5TCY9, Q96QK3
    UniProtKB/TrEMBL
    A8K7E4
    Related
    ENSP00000356213.3, ENST00000367244.8
    Conserved Domains (1) summary
    pfam00123
    Location:81107
    Hormone_2; Peptide hormone
  2. NM_194435.3NP_919416.1  VIP peptides isoform 2 preproprotein

    See identical proteins and their annotated locations for NP_919416.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    BC009794, BM971673, DA914915
    Consensus CDS
    CCDS5241.1
    UniProtKB/TrEMBL
    A8K7E4
    Related
    ENSP00000356212.3, ENST00000367243.7
    Conserved Domains (1) summary
    pfam00123
    Location:81107
    Hormone_2; Peptide hormone

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    152750797..152759760
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006715562.5XP_006715625.1  VIP peptides isoform X1

    See identical proteins and their annotated locations for XP_006715625.1

    UniProtKB/TrEMBL
    A8K7E4
    Conserved Domains (1) summary
    pfam00123
    Location:81107
    Hormone_2; Peptide hormone
  2. XM_005267135.4XP_005267192.1  VIP peptides isoform X2

    See identical proteins and their annotated locations for XP_005267192.1

    UniProtKB/TrEMBL
    A8K7E4
    Conserved Domains (1) summary
    pfam00123
    Location:81107
    Hormone_2; Peptide hormone

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    153952118..153961081
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054356314.1XP_054212289.1  VIP peptides isoform X1

    UniProtKB/TrEMBL
    A8K7E4
  2. XM_054356315.1XP_054212290.1  VIP peptides isoform X2

    UniProtKB/TrEMBL
    A8K7E4
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