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ZNF7 zinc finger protein 7 [ Homo sapiens (human) ]

Gene ID: 7553, updated on 3-Apr-2024

Summary

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Official Symbol
ZNF7provided by HGNC
Official Full Name
zinc finger protein 7provided by HGNC
Primary source
HGNC:HGNC:13139
See related
Ensembl:ENSG00000147789 MIM:194531; AllianceGenome:HGNC:13139
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KOX4; zf30; HF.16
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be integral component of membrane. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 4.3), endometrium (RPKM 3.5) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See ZNF7 in Genome Data Viewer
Location:
8q24.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (144827560..144847508)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (146001303..146021302)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (146052945..146072893)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19709 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:146018867-146019815 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:146021109-146022007 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:146022008-146022906 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19710 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19711 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19712 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:146024705-146025602 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:146025603-146026501 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:146026502-146027399 Neighboring gene microRNA 6850 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28105 Neighboring gene ribosomal protein L8 Neighboring gene uncharacterized LOC100130027 Neighboring gene zinc finger protein 517 Neighboring gene hESC enhancers GRCh37_chr8:146052597-146053122 and GRCh37_chr8:146053123-146053648 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:146053649-146054174 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr8:146064238-146064791 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:146076290-146076441 Neighboring gene COMM domain containing 5 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:146077648-146078496 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19714 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28107 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28108 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28109 Neighboring gene zinc finger protein 250 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:146126184-146126788 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:146126789-146127391 Neighboring gene uncharacterized LOC124902042 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:146127392-146127995 Neighboring gene zinc finger protein 16 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19717

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. RNA sequencing and Immunohistochemistry Reveal ZFN7 as a Stronger Marker of Survival than Molecular Subtypes in G-CIMP-negative Glioblastoma. Esteve-Codina A, et al. Clin Cancer Res, 2021 Jan 15. PMID 33106291
  2. Specific interactions of the autoantigen L7 with multi-zinc finger protein ZNF7 and ribosomal protein S7. Witte S, et al. J Biol Chem, 1997 Aug 29. PMID 9268371
  3. cDNA isolation, expression analysis, and chromosomal localization of two human zinc finger genes. Lania L, et al. Genomics, 1990 Feb. PMID 2106481
  4. Computer sequence analysis of human highly conserved zinc finger modules. Petroni D, et al. DNA Seq, 1998. PMID 10520746
  5. Genome-wide linkage scans for type 2 diabetes mellitus in four ethnically diverse populations-significant evidence for linkage on chromosome 4q in African Americans: the Family Investigation of Nephropathy and Diabetes Research Group. Malhotra A, et al. Diabetes Metab Res Rev, 2009 Nov. PMID 19795399, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RNA sequencing and Immunohistochemistry Reveal ZFN7 as a Stronger Marker of Survival than Molecular Subtypes in G-CIMP-negative Glioblastoma.
    Title: RNA sequencing and Immunohistochemistry Reveal ZFN7 as a Stronger Marker of Survival than Molecular Subtypes in G-CIMP-negative Glioblastoma.
  2. Single-cell imaging revealed that RIPK3-dependent death caused inflammasome-dependent IL-1beta release from lipopolysaccharide-stimulated A20-deficient macrophages. Importantly, mutation of the A20 ZnF7 ubiquitin binding domain caused arthritis in mice, arguing that ZnF7-dependent inhibition of necroptosis is critical for A20 anti-inflammatory function in vivo.
    Title: A20 prevents inflammasome-dependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin-binding domain.
  3. Observational study of gene-disease association. (HuGE Navigator)
    Title: Genome-wide linkage scans for type 2 diabetes mellitus in four ethnically diverse populations-significant evidence for linkage on chromosome 4q in African Americans: the Family Investigation of Nephropathy and Diabetes Research Group.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ38706

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding TAS
Traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 7
Names
C2-H2 type zinc finger protein
Zinc finger protein-7 (KOX4)
zinc finger protein 7 (KOX 4, clone HF.16)
zinc finger protein HF.16
zinc finger protein KOX4
zinc finger protein zfp30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282795.2 → NP_001269724.1  zinc finger protein 7 isoform 1

    See identical proteins and their annotated locations for NP_001269724.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AF235103, AK300001
    Consensus CDS
    CCDS64996.1
    UniProtKB/TrEMBL
    B2R9D8
    Related
    ENSP00000393260.2, ENST00000446747.7
    Conserved Domains (7) summary
    PHA02693
    Location:54 → 127
    PHA02693; hypothetical protein; Provisional
    smart00349
    Location:15 → 76
    KRAB; krueppel associated box
    COG5048
    Location:229 → 686
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:454 → 474
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:592 → 614
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:15 → 52
    KRAB; KRAB box
    pfam13465
    Location:360 → 384
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001282796.2 → NP_001269725.1  zinc finger protein 7 isoform 3

    See identical proteins and their annotated locations for NP_001269725.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 3' terminal exon compared to variant 1. The enocded isoform (3) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AF235103, AI862153, AK096025
    Consensus CDS
    CCDS64998.1
    UniProtKB/Swiss-Prot
    P17097
    Related
    ENSP00000435252.1, ENST00000525266.5
    Conserved Domains (3) summary
    smart00349
    Location:4 → 65
    KRAB; krueppel associated box
    pfam01352
    Location:4 → 41
    KRAB; KRAB box
    pfam10212
    Location:30 → 129
    TTKRSYEDQ; Predicted coiled-coil domain-containing protein

  3. NM_001282797.2 → NP_001269726.1  zinc finger protein 7 isoform 4

    See identical proteins and their annotated locations for NP_001269726.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an exon in the 5' UTR which results in the use of a downstream start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus, compared to isoform 1. Variants 4 and 6 encode the same protein (isoform 4).
    Source sequence(s)
    AF235103, AK301561, M29580
    Consensus CDS
    CCDS64999.1
    UniProtKB/TrEMBL
    F5H290, Q59F42
    Related
    ENSP00000439424.1, ENST00000544249.2
    Conserved Domains (2) summary
    COG5048
    Location:122 → 543
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:347 → 367
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. NM_001330623.1 → NP_001317552.1  zinc finger protein 7 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AF235103, AK300001, DA538365
    Consensus CDS
    CCDS83336.1
    UniProtKB/TrEMBL
    E9PIH3
    Related
    ENSP00000318848.5, ENST00000325217.10

  5. NM_001349805.2 → NP_001336734.1  zinc finger protein 7 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AF235103, BC058923, DB554904, DC345768, M29580
    Consensus CDS
    CCDS64999.1
    UniProtKB/TrEMBL
    F5H290, Q59F42
    Conserved Domains (2) summary
    COG5048
    Location:122 → 543
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:347 → 367
    ZF_C2H2; C2H2 Zn finger [structural motif]

  6. NM_001349806.2 → NP_001336735.1  zinc finger protein 7 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AF235103, BC058923, BJ989518, DB554904, DC345768, DC357767, M29580
    UniProtKB/TrEMBL
    B2R9D8
    Conserved Domains (4) summary
    smart00349
    Location:21 → 82
    KRAB; krueppel associated box
    COG5048
    Location:235 → 692
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:460 → 480
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl28640
    Location:60 → 133
    PHA02693; hypothetical protein; Provisional

  7. NM_001349807.2 → NP_001336736.1  zinc finger protein 7 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AF235103, BC058923, BJ989518, DA926250, DB554904, DC345768, M29580
    Consensus CDS
    CCDS94368.1
    UniProtKB/TrEMBL
    B2R9D8, E9PJX9
    Related
    ENSP00000433656.2, ENST00000527218.6
    Conserved Domains (4) summary
    smart00349
    Location:4 → 64
    KRAB; krueppel associated box
    COG5048
    Location:217 → 674
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:442 → 462
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl28640
    Location:46 → 115
    PHA02693; hypothetical protein; Provisional

  8. NM_001349808.2 → NP_001336737.1  zinc finger protein 7 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AF235103, BC058923, BJ989518, CD617091, DB554904, DC345768, DC357767, M29580
    UniProtKB/TrEMBL
    B2R9D8
    Conserved Domains (4) summary
    smart00349
    Location:21 → 81
    KRAB; krueppel associated box
    COG5048
    Location:234 → 691
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:459 → 479
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl28640
    Location:63 → 132
    PHA02693; hypothetical protein; Provisional

  9. NM_001349809.2 → NP_001336738.1  zinc finger protein 7 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AF235103, BC058923, CT004931, DB554904, DC345768, DC357767, M29580
    UniProtKB/TrEMBL
    B2R9D8
    Conserved Domains (4) summary
    smart00349
    Location:25 → 86
    KRAB; krueppel associated box
    COG5048
    Location:239 → 696
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:464 → 484
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl28640
    Location:64 → 137
    PHA02693; hypothetical protein; Provisional

  10. NM_003416.4 → NP_003407.1  zinc finger protein 7 isoform 2

    See identical proteins and their annotated locations for NP_003407.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AF235103, BC058923
    Consensus CDS
    CCDS6435.1
    UniProtKB/Swiss-Prot
    B4DT08, D3DWN6, P17015, P17097, Q8N8Y4
    UniProtKB/TrEMBL
    B2R9D8
    Related
    ENSP00000432641.2, ENST00000532777.6
    Conserved Domains (7) summary
    PHA02693
    Location:43 → 116
    PHA02693; hypothetical protein; Provisional
    smart00349
    Location:4 → 65
    KRAB; krueppel associated box
    COG5048
    Location:218 → 675
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:443 → 463
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:581 → 603
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:4 → 41
    KRAB; KRAB box
    pfam13465
    Location:349 → 373
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    144827560..144847508
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047422206.1 → XP_047278162.1  zinc finger protein 7 isoform X7

  2. XM_017013816.3 → XP_016869305.1  zinc finger protein 7 isoform X8

  3. XM_011517294.3 → XP_011515596.1  zinc finger protein 7 isoform X1

    See identical proteins and their annotated locations for XP_011515596.1

    UniProtKB/Swiss-Prot
    B4DT08, D3DWN6, P17015, P17097, Q8N8Y4
    UniProtKB/TrEMBL
    B2R9D8
    Conserved Domains (7) summary
    PHA02693
    Location:43 → 116
    PHA02693; hypothetical protein; Provisional
    smart00349
    Location:4 → 65
    KRAB; krueppel associated box
    COG5048
    Location:218 → 675
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:443 → 463
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:581 → 603
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:4 → 41
    KRAB; KRAB box
    pfam13465
    Location:349 → 373
    zf-H2C2_2; Zinc-finger double domain

  4. XM_011517292.4 → XP_011515594.1  zinc finger protein 7 isoform X5

    See identical proteins and their annotated locations for XP_011515594.1

    UniProtKB/TrEMBL
    B2R9D8
    Conserved Domains (7) summary
    PHA02693
    Location:54 → 127
    PHA02693; hypothetical protein; Provisional
    smart00349
    Location:15 → 76
    KRAB; krueppel associated box
    COG5048
    Location:229 → 686
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:454 → 474
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:592 → 614
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:15 → 52
    KRAB; KRAB box
    pfam13465
    Location:360 → 384
    zf-H2C2_2; Zinc-finger double domain

  5. XM_011517293.3 → XP_011515595.1  zinc finger protein 7 isoform X1

    See identical proteins and their annotated locations for XP_011515595.1

    UniProtKB/Swiss-Prot
    B4DT08, D3DWN6, P17015, P17097, Q8N8Y4
    UniProtKB/TrEMBL
    B2R9D8
    Related
    ENSP00000432724.1, ENST00000528372.5
    Conserved Domains (7) summary
    PHA02693
    Location:43 → 116
    PHA02693; hypothetical protein; Provisional
    smart00349
    Location:4 → 65
    KRAB; krueppel associated box
    COG5048
    Location:218 → 675
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:443 → 463
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:581 → 603
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:4 → 41
    KRAB; KRAB box
    pfam13465
    Location:349 → 373
    zf-H2C2_2; Zinc-finger double domain

  6. XM_011517296.4 → XP_011515598.1  zinc finger protein 7 isoform X2

    See identical proteins and their annotated locations for XP_011515598.1

    UniProtKB/TrEMBL
    B2R9D8, E9PJX9
    Conserved Domains (4) summary
    smart00349
    Location:4 → 64
    KRAB; krueppel associated box
    COG5048
    Location:217 → 674
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:442 → 462
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl28640
    Location:46 → 115
    PHA02693; hypothetical protein; Provisional

  7. XM_047422204.1 → XP_047278160.1  zinc finger protein 7 isoform X3

  8. XM_006716654.4 → XP_006716717.1  zinc finger protein 7 isoform X6

    See identical proteins and their annotated locations for XP_006716717.1

    UniProtKB/TrEMBL
    F5H290, Q59F42
    Conserved Domains (2) summary
    COG5048
    Location:122 → 543
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:347 → 367
    ZF_C2H2; C2H2 Zn finger [structural motif]

  9. XM_047422205.1 → XP_047278161.1  zinc finger protein 7 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    146001303..146021302
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054361194.1 → XP_054217169.1  zinc finger protein 7 isoform X8

  2. XM_054361189.1 → XP_054217164.1  zinc finger protein 7 isoform X3

  3. XM_054361192.1 → XP_054217167.1  zinc finger protein 7 isoform X6

    UniProtKB/TrEMBL
    B4DWJ4

  4. XM_054361186.1 → XP_054217161.1  zinc finger protein 7 isoform X1

  5. XM_054361193.1 → XP_054217168.1  zinc finger protein 7 isoform X7

  6. XM_054361187.1 → XP_054217162.1  zinc finger protein 7 isoform X1

  7. XM_054361188.1 → XP_054217163.1  zinc finger protein 7 isoform X2

  8. XM_054361191.1 → XP_054217166.1  zinc finger protein 7 isoform X5

  9. XM_054361190.1 → XP_054217165.1  zinc finger protein 7 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P17097.1 GenPept UniProtKB/Swiss-Prot:P17097

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