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ZNF35 zinc finger protein 35 [ Homo sapiens (human) ]

Gene ID: 7584, updated on 7-Apr-2024

Summary

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Official Symbol
ZNF35provided by HGNC
Official Full Name
zinc finger protein 35provided by HGNC
Primary source
HGNC:HGNC:13099
See related
Ensembl:ENSG00000169981 MIM:194533; AllianceGenome:HGNC:13099
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HF10; HF.10; Zfp105
Summary
Enables DNA-binding transcription factor activity and sequence-specific DNA binding activity. Predicted to be involved in cellular response to retinoic acid; regulation of transcription by RNA polymerase II; and spermatogenesis. Located in nucleus and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 5.6), urinary bladder (RPKM 2.4) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
3p21.31
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (44646506..44660791)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (44662214..44676499)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (44690224..44702283)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ZKSCAN7 ZNF cluster antisense RNA 1 Neighboring gene ZNF660-ZNF197 readthrough Neighboring gene zinc finger protein 660 Neighboring gene ZNF197 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14270 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:44666861-44667363 Neighboring gene zinc finger protein 197 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:44689909-44690468 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19768 Neighboring gene zinc finger protein 251 pseudogene Neighboring gene zinc finger protein OZF-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14271 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14272 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19769

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Localization of the human HF.10 finger gene on a chromosome region (3p21-22) frequently deleted in human cancers. Donti E, et al. Hum Genet, 1990 Apr. PMID 2108922
  2. The ZNF35 human zinc finger gene encodes a sequence-specific DNA-binding protein. Pengue G, et al. FEBS Lett, 1993 Apr 26. PMID 8477855
  3. Isolation of cDNAs encoding finger proteins and measurement of the corresponding mRNA levels during myeloid terminal differentiation. Pannuti A, et al. Nucleic Acids Res, 1988 May 25. PMID 3380682, Free PMC Article
  4. Structural and functional organization of the HF.10 human zinc finger gene (ZNF35) located on chromosome 3p21-p22. Lanfrancone L, et al. Genomics, 1992 Apr. PMID 1572646
  5. Expression of zinc finger protein 105 in the testis and its role in male fertility. Zhou H, et al. Mol Reprod Dev, 2010 Jun. PMID 20186958, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding TAS
Traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to retinoic acid ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in regulation of DNA-templated transcription TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermatogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zinc finger protein 35
Names
zinc finger protein 35 (clone HF.10)
zinc finger protein HF.10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003420.4 → NP_003411.3  zinc finger protein 35

    See identical proteins and their annotated locations for NP_003411.3

    Status: VALIDATED

    Source sequence(s)
    AC099669, BC013597, BC015892, BP237260
    Consensus CDS
    CCDS2718.2
    UniProtKB/Swiss-Prot
    B2RBU6, P13682, Q53Y54, Q96D01
    Related
    ENSP00000379368.2, ENST00000396056.7
    Conserved Domains (4) summary
    COG5048
    Location:214 → 369
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:336 → 356
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:474 → 496
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:488 → 513
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    44646506..44660791
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047448870.1 → XP_047304826.1  zinc finger protein 35 isoform X1

    UniProtKB/Swiss-Prot
    B2RBU6, P13682, Q53Y54, Q96D01

  2. XM_047448869.1 → XP_047304825.1  zinc finger protein 35 isoform X1

    UniProtKB/Swiss-Prot
    B2RBU6, P13682, Q53Y54, Q96D01

  3. XM_047448866.1 → XP_047304822.1  zinc finger protein 35 isoform X1

    UniProtKB/Swiss-Prot
    B2RBU6, P13682, Q53Y54, Q96D01

  4. XM_047448867.1 → XP_047304823.1  zinc finger protein 35 isoform X1

    UniProtKB/Swiss-Prot
    B2RBU6, P13682, Q53Y54, Q96D01

  5. XM_047448868.1 → XP_047304824.1  zinc finger protein 35 isoform X1

    UniProtKB/Swiss-Prot
    B2RBU6, P13682, Q53Y54, Q96D01

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_009646197.1 Reference GRCh38.p14 PATCHES

    Range
    171860..186145
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054331561.1 → XP_054187536.1  zinc finger protein 35 isoform X1

    UniProtKB/Swiss-Prot
    B2RBU6, P13682, Q53Y54, Q96D01

  2. XM_054331560.1 → XP_054187535.1  zinc finger protein 35 isoform X1

    UniProtKB/Swiss-Prot
    B2RBU6, P13682, Q53Y54, Q96D01

  3. XM_054331558.1 → XP_054187533.1  zinc finger protein 35 isoform X1

    UniProtKB/Swiss-Prot
    B2RBU6, P13682, Q53Y54, Q96D01

  4. XM_054331559.1 → XP_054187534.1  zinc finger protein 35 isoform X1

    UniProtKB/Swiss-Prot
    B2RBU6, P13682, Q53Y54, Q96D01

  5. XM_054331557.1 → XP_054187532.1  zinc finger protein 35 isoform X1

    UniProtKB/Swiss-Prot
    B2RBU6, P13682, Q53Y54, Q96D01

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    44662214..44676499
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054347767.1 → XP_054203742.1  zinc finger protein 35 isoform X1

    UniProtKB/Swiss-Prot
    B2RBU6, P13682, Q53Y54, Q96D01

  2. XM_054347766.1 → XP_054203741.1  zinc finger protein 35 isoform X1

    UniProtKB/Swiss-Prot
    B2RBU6, P13682, Q53Y54, Q96D01

  3. XM_054347764.1 → XP_054203739.1  zinc finger protein 35 isoform X1

    UniProtKB/Swiss-Prot
    B2RBU6, P13682, Q53Y54, Q96D01

  4. XM_054347765.1 → XP_054203740.1  zinc finger protein 35 isoform X1

    UniProtKB/Swiss-Prot
    B2RBU6, P13682, Q53Y54, Q96D01

  5. XM_054347763.1 → XP_054203738.1  zinc finger protein 35 isoform X1

    UniProtKB/Swiss-Prot
    B2RBU6, P13682, Q53Y54, Q96D01
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P13682.4 GenPept UniProtKB/Swiss-Prot:P13682

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