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Zmym2 zinc finger, MYM-type 2 [ Mus musculus (house mouse) ]

Gene ID: 76007, updated on 5-Mar-2024

Summary

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Official Symbol
Zmym2provided by MGI
Official Full Name
zinc finger, MYM-type 2provided by MGI
Primary source
MGI:MGI:1923257
See related
Ensembl:ENSMUSG00000021945 AllianceGenome:MGI:1923257
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FIM; MYM; RAMP; SCLL; Zfp198; Znf198; 5830413P05Rik
Summary
This gene encodes a protein that contains nine MYM-type zinc finger motifs. Expression of this gene may mediate the inhibition of hematopoietic cell development during ontogeny, and the encoded protein may also play a role in transforming growth factor-beta signaling as a Smad binding protein. [provided by RefSeq, Feb 2011]
Expression
Broad expression in CNS E11.5 (RPKM 12.5), CNS E14 (RPKM 11.4) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Zmym2 in Genome Data Viewer
Location:
14 C3; 14 28.99 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (57123986..57199815)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (56886529..56962358)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22218 Neighboring gene STARR-seq mESC enhancer starr_36800 Neighboring gene STARR-seq mESC enhancer starr_36801 Neighboring gene cyclin I pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1896 Neighboring gene STARR-seq mESC enhancer starr_36803 Neighboring gene STARR-seq mESC enhancer starr_36804 Neighboring gene predicted gene, 36789 Neighboring gene RIKEN cDNA B020004C17 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Negative regulation of hematopoiesis by the fused in myeloproliferative disorders gene product. Inoue H, et al. Biochem Biophys Res Commun, 2004 Jan 2. PMID 14672707
  2. Proteomic analysis identifies ZMYM2 as endogenous binding partner of TBX18 protein in 293 and A549 cells. Lüdtke TH, et al. Biochem J, 2022 Jan 14. PMID 34935912
  3. Constitutive Notch pathway activation in murine ZMYM2-FGFR1-induced T-cell lymphomas associated with atypical myeloproliferative disease. Ren M, et al. Blood, 2011 Jun 23. PMID 21527531, Free PMC Article
  4. Identification of novel Smad binding proteins. Warner DR, et al. Biochem Biophys Res Commun, 2003 Dec 26. PMID 14651998
  5. HECT E3 Ubiquitin Ligase Itch Functions as a Novel Negative Regulator of Gli-Similar 3 (Glis3) Transcriptional Activity. ZeRuth GT, et al. PLoS One, 2015. PMID 26147758, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZMYM2 is essential for methylation of germline genes and active transposons in embryonic development.
    Title: ZMYM2 is essential for methylation of germline genes and active transposons in embryonic development.
  2. The study demonstrates frequent, constitutive activation of Notch1 and its downstream target genes in T-cell lymphomas that arose in a murine model of Zmym2-Fgfr1 stem cell leukemia-lymphoma syndrome.
    Title: Constitutive Notch pathway activation in murine ZMYM2-FGFR1-induced T-cell lymphomas associated with atypical myeloproliferative disease.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (5)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC51607

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin conjugating enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in PML body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger MYM-type protein 2
Names
zinc finger protein 198

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360643.1 → NP_001347572.1  zinc finger MYM-type protein 2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC154303, AK135499, AK137720, AV142652, BE993957, BU055093, CA536924, CV561457
    Consensus CDS
    CCDS49506.1
    UniProtKB/Swiss-Prot
    B2RUS2, Q3UUZ8, Q3UXK7, Q80XP0, Q9CU65
    Conserved Domains (2) summary
    pfam06467
    Location:461 → 501
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:1197 → 1359
    DUF3504; Domain of unknown function (DUF3504)

  2. NM_029498.4 → NP_083774.2  zinc finger MYM-type protein 2 isoform 1

    See identical proteins and their annotated locations for NP_083774.2

    Status: REVIEWED

    Source sequence(s)
    AC154303, AK135499, AK137720, AV142652, BE993957, CA536924, CJ110016, CV561457
    Consensus CDS
    CCDS49506.1
    UniProtKB/Swiss-Prot
    B2RUS2, Q3UUZ8, Q3UXK7, Q80XP0, Q9CU65
    Related
    ENSMUSP00000022511.9, ENSMUST00000022511.10
    Conserved Domains (2) summary
    pfam06467
    Location:461 → 501
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:1197 → 1359
    DUF3504; Domain of unknown function (DUF3504)

  3. NM_177627.3 → NP_808295.2  zinc finger MYM-type protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC154303, AK135499, CJ110016
    Consensus CDS
    CCDS88674.1
    UniProtKB/TrEMBL
    A0A286YCD5, Q80V89
    Related
    ENSMUSP00000152925.2, ENSMUST00000223669.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    57123986..57199815
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011245220.3 → XP_011243522.1  zinc finger MYM-type protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011243522.1

    Conserved Domains (2) summary
    pfam06467
    Location:461 → 501
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:1223 → 1385
    DUF3504; Domain of unknown function (DUF3504)

  2. XM_011245221.3 → XP_011243523.1  zinc finger MYM-type protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011243523.1

    Conserved Domains (2) summary
    pfam06467
    Location:461 → 501
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:1223 → 1385
    DUF3504; Domain of unknown function (DUF3504)

  3. XM_011245219.3 → XP_011243521.1  zinc finger MYM-type protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011243521.1

    Conserved Domains (2) summary
    pfam06467
    Location:461 → 501
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:1223 → 1385
    DUF3504; Domain of unknown function (DUF3504)

  4. XM_030248091.1 → XP_030103951.1  zinc finger MYM-type protein 2 isoform X2

    UniProtKB/Swiss-Prot
    B2RUS2, Q3UUZ8, Q3UXK7, Q80XP0, Q9CU65
    Conserved Domains (2) summary
    pfam06467
    Location:461 → 501
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:1197 → 1359
    DUF3504; Domain of unknown function (DUF3504)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CU65.3 GenPept UniProtKB/Swiss-Prot:Q9CU65

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