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CA3 carbonic anhydrase 3 [ Homo sapiens (human) ]

Gene ID: 761, updated on 4-Jan-2025

Summary

Official Symbol
CA3provided by HGNC
Official Full Name
carbonic anhydrase 3provided by HGNC
Primary source
HGNC:HGNC:1374
See related
Ensembl:ENSG00000164879 MIM:114750; AllianceGenome:HGNC:1374
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Car3; CAIII
Summary
Carbonic anhydrase III (CAIII) is a member of a multigene family (at least six separate genes are known) that encodes carbonic anhydrase isozymes. These carbonic anhydrases are a class of metalloenzymes that catalyze the reversible hydration of carbon dioxide and are differentially expressed in a number of cell types. The expression of the CA3 gene is strictly tissue specific and present at high levels in skeletal muscle and much lower levels in cardiac and smooth muscle. A proportion of carriers of Duchenne muscle dystrophy have a higher CA3 level than normal. The gene spans 10.3 kb and contains seven exons and six introns. [provided by RefSeq, Oct 2008]
Expression
Biased expression in prostate (RPKM 78.7), fat (RPKM 38.8) and 3 other tissues See more
Orthologs
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Genomic context

See CA3 in Genome Data Viewer
Location:
8q21.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (85438859..85449040)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (85877589..85887769)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (86351088..86361269)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19336 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27594 Neighboring gene carbonic anhydrase 13 Neighboring gene NANOG hESC enhancer GRCh37_chr8:86229148-86229679 Neighboring gene uncharacterized LOC124901970 Neighboring gene carbonic anhydrase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27595 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19337 Neighboring gene CA1 upstream erythroid promoter Neighboring gene NANOG hESC enhancer GRCh37_chr8:86316751-86317252 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:86350401-86350924 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:86350925-86351447 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:86373749-86374444 Neighboring gene CA3 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19338 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19339 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:86376345-86376844 Neighboring gene uncharacterized LOC105375937 Neighboring gene carbonic anhydrase 2

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study identifies loci affecting blood copper, selenium and zinc.
EBI GWAS Catalog

Pathways from PubChem

Interactions

General gene information

Potential readthrough

Included gene: CA13

Clone Names

  • FLJ36434

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carbonate dehydratase activity  
enables carbonate dehydratase activity PubMed 
enables nickel cation binding  
enables protein binding PubMed 
enables zinc ion binding  
Component Evidence Code Pubs
is_active_in cytoplasm  
is_active_in cytosol  
is_active_in cytosol PubMed 
located_in cytosol  

General protein information

Preferred Names
carbonic anhydrase 3
Names
CA-III
HEL-S-167mP
carbonate dehydratase III
carbonic anhydrase III, muscle specific
carbonic anhydrase IIII
epididymis secretory sperm binding protein Li 167mP
NP_005172.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005181.4NP_005172.1  carbonic anhydrase 3

    See identical proteins and their annotated locations for NP_005172.1

    Status: REVIEWED

    Source sequence(s)
    AC084734, AK313254, DA421884
    Consensus CDS
    CCDS6238.1
    UniProtKB/Swiss-Prot
    B2R867, B3KUC8, O60842, P07451
    UniProtKB/TrEMBL
    B4DUJ8, V9HWA3
    Related
    ENSP00000285381.2, ENST00000285381.3
    Conserved Domains (1) summary
    cd03119
    Location:1259
    alpha_CA_I_II_III_XIII; Carbonic anhydrase alpha, isozymes I, II, and III and XIII. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    85438859..85449040
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    85877589..85887769
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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