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pdpk1a 3-phosphoinositide dependent protein kinase 1a [ Danio rerio (zebrafish) ]

Gene ID: 768202, updated on 27-Mar-2024

Summary

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Official Symbol
pdpk1aprovided by ZNC
Official Full Name
3-phosphoinositide dependent protein kinase 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-061013-109
See related
Ensembl:ENSDARG00000062304 AllianceGenome:ZFIN:ZDB-GENE-061013-109
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
im:7158209; zgc:153787
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction and peptidyl-serine phosphorylation. Predicted to act upstream of or within protein phosphorylation. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human PDPK1 (3-phosphoinositide dependent protein kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See pdpk1a in Genome Data Viewer
Location:
chromosome: 3
Exon count:
13
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (45286086..45298487, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (47333752..47346153, complement)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 31 Neighboring gene potassium channel tetramerization domain containing 5a Neighboring gene interleukin 21 receptor, tandem duplicate 2 Neighboring gene interleukin 21 receptor, tandem duplicate 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Effects of the protein kinase inhibitor PKC412 on gene expression and link to physiological effects in zebrafish Danio rerio eleuthero-embryos. Oggier DM, et al. Toxicol Sci, 2011 Jan. PMID 20980353
  2. High-carbohydrate diet promotes the adaptation to acute hypoxia in zebrafish. Ma Q, et al. Fish Physiol Biochem, 2020 Apr. PMID 31820205
  3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
3-phosphoinositide-dependent protein kinase 1a
NP_001070812.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077344.1 → NP_001070812.1  3-phosphoinositide-dependent protein kinase 1a precursor

    See identical proteins and their annotated locations for NP_001070812.1

    Status: PROVISIONAL

    Source sequence(s)
    BC124736
    UniProtKB/TrEMBL
    Q08BG3
    Related
    ENSDARP00000093021.3, ENSDART00000102245.5
    Conserved Domains (3) summary
    smart00220
    Location:77 → 324
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd01262
    Location:429 → 531
    PH_PDK1; 3-Phosphoinositide dependent protein kinase 1 (PDK1) pleckstrin homology (PH) domain
    cd05581
    Location:75 → 337
    STKc_PDK1; Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    45286086..45298487 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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