Ak7 adenylate kinase 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ak7provided by MGI
Official Full Name: adenylate kinase 7provided by MGI
Primary source: MGI:MGI:1926051
See related: Ensembl:ENSMUSG00000041323 AllianceGenome:MGI:1926051
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AK 7; 4930502N02Rik
Summary: Predicted to enable adenylate kinase activity; cytidylate kinase activity; and nucleoside diphosphate kinase activity. Acts upstream of or within several processes, including axoneme assembly; epithelial cilium movement involved in extracellular fluid movement; and inflammatory response to antigenic stimulus. Predicted to be located in motile cilium. Predicted to be active in cytoplasm. Is expressed in lung; lung epithelium; and nasal cavity respiratory epithelium. Used to study hydrocephalus. Human ortholog(s) of this gene implicated in spermatogenic failure 27. Orthologous to human AK7 (adenylate kinase 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis adult (RPKM 10.7), lung adult (RPKM 1.2) and 1 other tissue See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 12 E; 12 55.95 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (105670115..105748706)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (105703858..105782447)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that a mutation of the adenylate kinase 7 gene results in animals with pathological signs characteristic of primary ciliary dyskinesia, including ultrastructural ciliary defects and decreased ciliary beat frequency in respiratory epithelium.
Title: Mutation of murine adenylate kinase 7 underlies a primary ciliary dyskinesia phenotype.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Transgenic (1) 1 citation
Gene trapped (1)
Endonuclease-mediated (2)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

AU015738 (e-PCR)
- UniSTS:208865

AU015738 (e-PCR)
- UniSTS:180467

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables adenylate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenylate kinase activity	ISO Inferred from Sequence Orthology more info
enables cytidylate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytidylate kinase activity	ISO Inferred from Sequence Orthology more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleobase-containing compound kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleoside diphosphate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleoside diphosphate kinase activity	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within axoneme assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell projection organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within epithelial cilium movement involved in extracellular fluid movement	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inflammatory response to antigenic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleobase-containing compound metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cilium	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in motile cilium	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: adenylate kinase 7

Names: ATP-AMP transphosphorylase 7; putative adenylate kinase 7

NP_084463.1

EC 2.7.4.3

EC 2.7.4.6

XP_006516453.1

EC 2.7.4.3

EC 2.7.4.6

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_030187.1 → NP_084463.1 adenylate kinase 7

Status: VALIDATED

Source sequence(s)

AK019664, AK029555

Consensus CDS

CCDS49162.1

UniProtKB/Swiss-Prot

Q8BVH3, Q9D2H2

UniProtKB/TrEMBL

F8WIC0

Related

ENSMUSP00000043145.6, ENSMUST00000040876.7

Conserved Domains (4) summary

COG0451
Location:147 → 297

WcaG; Nucleoside-diphosphate-sugar epimerase [Cell wall/membrane/envelope biogenesis]

cd01428
Location:369 → 548

ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...

pfam05186
Location:679 → 720

Dpy-30; Dpy-30 motif

cl21454
Location:218 → 298

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

105670115..105748706

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006516390.4 → XP_006516453.1 adenylate kinase 7 isoform X1

UniProtKB/Swiss-Prot

Q8BVH3, Q9D2H2

Conserved Domains (3) summary

cd01428
Location:343 → 522

ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...

TIGR01777
Location:82 → 268

yfcH; TIGR01777 family protein

pfam05186
Location:653 → 694

Dpy-30; Dpy-30 motif