slc9a1b solute carrier family 9 member A1b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: slc9a1bprovided by ZNC
Official Full Name: solute carrier family 9 member A1bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-080225-42
See related: Ensembl:ENSDARG00000097339 AllianceGenome:ZFIN:ZDB-GENE-080225-42
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: nhe1; slc9a1
Summary: Predicted to enable potassium:proton antiporter activity and sodium:proton antiporter activity. Predicted to be involved in potassium ion transmembrane transport; regulation of intracellular pH; and sodium ion import across plasma membrane. Predicted to act upstream of or within regulation of pH; sodium ion transport; and transmembrane transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in blood and gill. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 19 and congestive heart failure. Orthologous to human SLC9A1 (solute carrier family 9 member A1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 17

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (53418426..53431206)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (53309479..53309929)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AU048745 (e-PCR)
- UniSTS:145195

G44841 (e-PCR)
- UniSTS:105643

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables antiporter activity	IEA Inferred from Electronic Annotation more info
enables potassium:proton antiporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium:proton antiporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium:proton antiporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within monoatomic cation transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of intracellular pH	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of pH	IEA Inferred from Electronic Annotation more info
involved_in sodium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sodium ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in lateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: sodium/hydrogen exchanger 1; sodium/hydrogen exchanger 1b

Names: sodium hydrogen exchanger 1; solute carrier family 9 (sodium/hydrogen exchanger), member 1; solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001113480.1 → NP_001106952.1 sodium/hydrogen exchanger 1b precursor

See identical proteins and their annotated locations for NP_001106952.1

Status: PROVISIONAL

Source sequence(s)

EF591982

UniProtKB/TrEMBL

A9XP99

Related

ENSDARP00000088401.5, ENSDART00000097631.5

Conserved Domains (3) summary

TIGR00840
Location:36 → 591

b_cpa1; sodium/hydrogen exchanger 3

pfam00999
Location:45 → 443

Na_H_Exchanger; Sodium/hydrogen exchanger family

pfam16644
Location:533 → 628

NEXCaM_BD; Regulatory region of Na+/H+ exchanger NHE binds to calmodulin

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007128.7 Reference GRCz11 Primary Assembly

Range

53418426..53431206

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021467241.1 → XP_021322916.1 sodium/hydrogen exchanger 1 isoform X3

UniProtKB/TrEMBL

A0A8M9PKX4

Conserved Domains (1) summary

cl25615
Location:36 → 368

NhaP2; NhaP-type Na+/H+ and K+/H+ antiporter with C-terminal TrkAC and CorC domains [Energy production and conversion, Inorganic ion transport and metabolism]
XM_021467239.1 → XP_021322914.1 sodium/hydrogen exchanger 1 isoform X1

UniProtKB/TrEMBL

A0A8M9PEE6

Conserved Domains (1) summary

cl25615
Location:36 → 536

NhaP2; NhaP-type Na+/H+ and K+/H+ antiporter with C-terminal TrkAC and CorC domains [Energy production and conversion, Inorganic ion transport and metabolism]
XM_021467240.1 → XP_021322915.1 sodium/hydrogen exchanger 1 isoform X2

UniProtKB/TrEMBL

A0A8M9PNY2

Conserved Domains (1) summary

cl25615
Location:53 → 432

NhaP2; NhaP-type Na+/H+ and K+/H+ antiporter with C-terminal TrkAC and CorC domains [Energy production and conversion, Inorganic ion transport and metabolism]