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AIMP2 aminoacyl tRNA synthetase complex interacting multifunctional protein 2 [ Homo sapiens (human) ]

Gene ID: 7965, updated on 3-Apr-2024

Summary

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Official Symbol
AIMP2provided by HGNC
Official Full Name
aminoacyl tRNA synthetase complex interacting multifunctional protein 2provided by HGNC
Primary source
HGNC:HGNC:20609
See related
Ensembl:ENSG00000106305 MIM:600859; AllianceGenome:HGNC:20609
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P38; JTV1; HLD17; JTV-1
Summary
The protein encoded by this gene is part of the aminoacyl-tRNA synthetase complex, which contains nine different aminoacyl-tRNA synthetases and three non-enzymatic factors. The encoded protein is one of the non-enzymatic factors and is required for assembly and stability of the complex. [provided by RefSeq, May 2016]
Expression
Ubiquitous expression in testis (RPKM 18.6), duodenum (RPKM 17.0) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
7p22.1
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (6009272..6023834)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (6127037..6141607)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (6048903..6063465)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene CCZ1 homolog, vacuolar protein trafficking and biogenesis associated Neighboring gene radial spoke head 10 homolog B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5987517-5988017 Neighboring gene PMS1 homolog 2, mismatch repair system component Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:6047103-6047794 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25614 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17931 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25615 Neighboring gene small nucleolar RNA, H/ACA box 80D Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:6065935-6066435 Neighboring gene eukaryotic translation initiation factor 2 alpha kinase 1 Neighboring gene ankyrin repeat domain 61 Neighboring gene RNA, 7SL, cytoplasmic 851, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Single-cell analysis of AIMP2 splice variants informs on drug sensitivity and prognosis in hematologic cancer. Ku J, et al. Commun Biol, 2020 Oct 30. PMID 33128014, Free PMC Article
  2. An Isoform of the Oncogenic Splice Variant AIMP2-DX2 Detected by a Novel Monoclonal Antibody. Kim DG, et al. Biomolecules, 2020 May 27. PMID 32471182, Free PMC Article
  3. Retractile lysyl-tRNA synthetase-AIMP2 assembly in the human multi-aminoacyl-tRNA synthetase complex. Hei Z, et al. J Biol Chem, 2019 Mar 29. PMID 30733335, Free PMC Article
  4. Label-free molecular probe based on G-quadruplex and strand displacement for sensitive and selective detection and naked eye discrimination of exon 2 deletion of AIMP2. Zang R, et al. Chem Biol Drug Des, 2019 Jun. PMID 30345633
  5. AIMP2-DX2 Promotes the Proliferation, Migration, and Invasion of Nasopharyngeal Carcinoma Cells. Cao Q, et al. Biomed Res Int, 2018. PMID 29854811, Free PMC Article

See all (160) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Discovery of two distinct aminoacyl-tRNA synthetase complexes anchored to the Plasmodium surface tRNA import protein.
    Title: Discovery of two distinct aminoacyl-tRNA synthetase complexes anchored to the Plasmodium surface tRNA import protein.
  2. AIMP2-DX2 provides therapeutic interface to control KRAS-driven tumorigenesis.
    Title: AIMP2-DX2 provides therapeutic interface to control KRAS-driven tumorigenesis.
  3. Single-cell analysis of AIMP2 splice variants informs on drug sensitivity and prognosis in hematologic cancer.
    Title: Single-cell analysis of AIMP2 splice variants informs on drug sensitivity and prognosis in hematologic cancer.
  4. An Isoform of the Oncogenic Splice Variant AIMP2-DX2 Detected by a Novel Monoclonal Antibody.
    Title: An Isoform of the Oncogenic Splice Variant AIMP2-DX2 Detected by a Novel Monoclonal Antibody.
  5. Structural insight into the interaction between p53 TAD1 and AIMP2-DX2 by NMR.
    Title: Structural insight into the interaction between p53 TAD1 and AIMP2-DX2 by NMR.
  6. developed a label-free method based on the formation of split G-quadruplex in the presence of target DNA combined with strand displacement to detect exon 2 deletion of AIMP2 (DE2) sensitively and selectively
    Title: Label-free molecular probe based on G-quadruplex and strand displacement for sensitive and selective detection and naked eye discrimination of exon 2 deletion of AIMP2.
  7. heat-shock protein HSP70 is a critical determinant for the level of AIMP2-DX2
    Title: Targeting the interaction of AIMP2-DX2 with HSP70 suppresses cancer development.
  8. Retractile lysyl-tRNA synthetase-AIMP2 assembly in the human multi-aminoacyl-tRNA synthetase complex.
    Title: Retractile lysyl-tRNA synthetase-AIMP2 assembly in the human multi-aminoacyl-tRNA synthetase complex.
  9. AIMP2-DX2 plays an important role in the regulation of Nasopharyngeal carcinoma.
    Title: AIMP2-DX2 Promotes the Proliferation, Migration, and Invasion of Nasopharyngeal Carcinoma Cells.
  10. Homozygosity for a nonsense variant in AIMP2 is associated with a progressive neurodevelopmental disorder with microcephaly, seizures, and spastic quadriparesis.
    Title: Homozygosity for a nonsense variant in AIMP2 is associated with a progressive neurodevelopmental disorder with microcephaly, seizures, and spastic quadriparesis.
Submit: New GeneRIF Correction See all GeneRIFs (25)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Leukodystrophy, hypomyelinating, 17
MedGen: C4693912 OMIM: 618006 GeneReviews: Not available
Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Interaction of HIV-1 Gag with aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 (AIMP2) is identified in a series of six affinity purification/mass spectrometry screens PubMed
matrix gag HIV-1 MA is identified to have a physical interaction with aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 (AIMP2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular adaptor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein-containing complex assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
involved_in type II pneumocyte differentiation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of aminoacyl-tRNA synthetase multienzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of aminoacyl-tRNA synthetase multienzyme complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in membrane HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
aminoacyl tRNA synthase complex-interacting multifunctional protein 2
Names
ARS-interacting multi-functional protein 2
multisynthase complex auxiliary component p38
multisynthetase complex auxiliary component p38
protein JTV-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050738.1 RefSeqGene

    Range
    5022..19584
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001326606.2 → NP_001313535.1  aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 3' end of the first exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AC005995, CX867709
    UniProtKB/TrEMBL
    B2R7M3
    Conserved Domains (1) summary
    cd03200
    Location:174 → 269
    GST_C_AIMP2; Glutathione S-transferase C-terminal-like, alpha helical domain of Aminoacyl tRNA synthetase complex-Interacting Multifunctional Protein 2

  2. NM_001326607.2 → NP_001313536.1  aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AC005995
    Consensus CDS
    CCDS87475.1
    UniProtKB/TrEMBL
    F8W950
    Related
    ENSP00000378658.2, ENST00000395236.2

  3. NM_001326609.2 → NP_001313538.1  aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 4, 5, and 6 all encode the same isoform (d).
    Source sequence(s)
    AC005995
    Consensus CDS
    CCDS87476.1
    UniProtKB/TrEMBL
    A8MU58
    Conserved Domains (2) summary
    cd03200
    Location:136 → 231
    GST_C_AIMP2; Glutathione S-transferase C-terminal-like, alpha helical domain of Aminoacyl tRNA synthetase complex-Interacting Multifunctional Protein 2
    pfam18569
    Location:39 → 130
    Thioredoxin_16; Thioredoxin-like domain

  4. NM_001326610.2 → NP_001313539.1  aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 4, 5, and 6 all encode the same isoform (d).
    Source sequence(s)
    AC005995
    Consensus CDS
    CCDS87476.1
    UniProtKB/TrEMBL
    A8MU58
    Related
    ENSP00000383327.2, ENST00000400479.6
    Conserved Domains (2) summary
    cd03200
    Location:136 → 231
    GST_C_AIMP2; Glutathione S-transferase C-terminal-like, alpha helical domain of Aminoacyl tRNA synthetase complex-Interacting Multifunctional Protein 2
    pfam18569
    Location:39 → 130
    Thioredoxin_16; Thioredoxin-like domain

  5. NM_001326611.3 → NP_001313540.1  aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 4, 5, and 6 all encode the same isoform (d).
    Source sequence(s)
    AC005995, AI479424, AW131494, CB152528, CX756571
    Consensus CDS
    CCDS87476.1
    UniProtKB/TrEMBL
    A8MU58
    Conserved Domains (2) summary
    cd03200
    Location:136 → 231
    GST_C_AIMP2; Glutathione S-transferase C-terminal-like, alpha helical domain of Aminoacyl tRNA synthetase complex-Interacting Multifunctional Protein 2
    pfam18569
    Location:39 → 130
    Thioredoxin_16; Thioredoxin-like domain

  6. NM_001362785.2 → NP_001349714.1  aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC005995, AI479424, AW131494, CX756571
    UniProtKB/TrEMBL
    B2R7M3
    Conserved Domains (1) summary
    cd03200
    Location:185 → 280
    GST_C_AIMP2; Glutathione S-transferase C-terminal-like, alpha helical domain of Aminoacyl tRNA synthetase complex-Interacting Multifunctional Protein 2

  7. NM_001362787.2 → NP_001349716.1  aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform f

    Status: REVIEWED

    Source sequence(s)
    AC005995, AI479424, AW131494, CX756571
    UniProtKB/TrEMBL
    B2R7M3
    Conserved Domains (1) summary
    cd03200
    Location:170 → 265
    GST_C_AIMP2; Glutathione S-transferase C-terminal-like, alpha helical domain of Aminoacyl tRNA synthetase complex-Interacting Multifunctional Protein 2

  8. NM_006303.4 → NP_006294.2  aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform a

    See identical proteins and their annotated locations for NP_006294.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC005995, BC002853
    Consensus CDS
    CCDS5344.1
    UniProtKB/Swiss-Prot
    F8W950, Q13155, Q75MR1, Q96CZ5, Q9P1L2
    UniProtKB/TrEMBL
    B2R7M3
    Related
    ENSP00000223029.3, ENST00000223029.8
    Conserved Domains (2) summary
    cd03200
    Location:214 → 309
    GST_C_AIMP2; Glutathione S-transferase C-terminal-like, alpha helical domain of Aminoacyl tRNA synthetase complex-Interacting Multifunctional Protein 2
    pfam16780
    Location:1 → 33
    AIMP2_LysRS_bd; AIMP2 lysyl-tRNA synthetase binding domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    6009272..6023834
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420835.1 → XP_047276791.1  aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform X2

  2. XM_047420834.1 → XP_047276790.1  aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform X2

  3. XM_005249847.4 → XP_005249904.1  aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform X1

    UniProtKB/TrEMBL
    B2R7M3
    Conserved Domains (1) summary
    cd03200
    Location:207 → 302
    GST_C_AIMP2; Glutathione S-transferase C-terminal-like, alpha helical domain of Aminoacyl tRNA synthetase complex-Interacting Multifunctional Protein 2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    6127037..6141607
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054359001.1 → XP_054214976.1  aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform X2

  2. XM_054359000.1 → XP_054214975.1  aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform X2

  3. XM_054358999.1 → XP_054214974.1  aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_018570.1: Suppressed sequence

    Description
    NM_018570.1: This RefSeq was removed because it is primarily UTR sequence.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q13155.2 GenPept UniProtKB/Swiss-Prot:Q13155

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