krt8 keratin 8 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: krt8provided by ZNC
Official Full Name: keratin 8provided by ZNC
Primary source: ZFIN:ZDB-GENE-030411-5
See related: Ensembl:ENSDARG00000058358 AllianceGenome:ZFIN:ZDB-GENE-030411-5
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zfk8; DreK8; cb186; zf-K8; krt2-8; sb:cb186; wu:fa20h05; wu:fa95h10; wu:fb96c06
Summary: Predicted to be located in cytoplasm. Is expressed in several structures, including EVL; cardiovascular system; integument; pectoral fin; and sensory system. Human ortholog(s) of this gene implicated in liver cirrhosis. Orthologous to several human genes including KRT8 (keratin 8). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 23

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (10249626..10254241, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (10314656..10319271, complement)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data identify Danio rerio keratins 8/18 as the true orthologs of the human keratin pair 8/18.
Title: cDNA sequences of the authentic keratins 8 and 18 in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Markers

fk07a11.x1 (e-PCR)
- UniSTS:200537

fa95h10.x1 (e-PCR)
- UniSTS:202602

fa14a08.s1 (e-PCR)
- UniSTS:202374

fb96c06 (e-PCR)
- UniSTS:189109

fa20h05.s1 (e-PCR)
- UniSTS:202472

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables structural constituent of skin epidermis	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in intermediate filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in keratinization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in intermediate filament	IEA Inferred from Electronic Annotation more info
is_active_in keratin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in keratin filament	IEA Inferred from Electronic Annotation more info
located_in nuclear matrix	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: keratin, type II cytoskeletal 8

Names: CK-8; K8; cytokeratin-8; etID33550.23; etID43142.23; etID43142.8; keratin, type 2, gene 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200080.2 → NP_956374.1 keratin, type II cytoskeletal 8

See identical proteins and their annotated locations for NP_956374.1

Status: PROVISIONAL

Source sequence(s)

BC067610

UniProtKB/Swiss-Prot

Q6NWF6, Q7ZT78

Related

ENSDARP00000075658.4, ENSDART00000081215.5

Conserved Domains (3) summary

pfam00038
Location:114 → 425

Filament; Intermediate filament protein

pfam16208
Location:87 → 111

Keratin_2_head; Keratin type II head

cl23720
Location:326 → 394

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)