MCTP1 multiple C2 and transmembrane domain containing 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MCTP1provided by HGNC
Official Full Name: multiple C2 and transmembrane domain containing 1provided by HGNC
Primary source: HGNC:HGNC:26183
See related: Ensembl:ENSG00000175471 MIM:616296; AllianceGenome:HGNC:26183
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: Enables calcium ion binding activity. Predicted to be involved in several processes, including modulation of chemical synaptic transmission; negative regulation of endocytosis; and negative regulation of response to oxidative stress. Is integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in brain (RPKM 4.3), fat (RPKM 3.5) and 22 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 5q15

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (94703690..95285094, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (95188075..95786099, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (94039395..94620798, complement)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Multiple C2 domain-containing transmembrane proteins promote lipid droplet biogenesis and growth at specialized endoplasmic reticulum subdomains.
Title: Multiple C2 domain-containing transmembrane proteins promote lipid droplet biogenesis and growth at specialized endoplasmic reticulum subdomains.
The DNA methylation-regulated MCTP1 activates the drug-resistance of esophageal cancer cells.
Title: The DNA methylation-regulated MCTP1 activates the drug-resistance of esophageal cancer cells.
This Gene-based tests suggest evidence of association with related genes, ZEB2, RND3, MCTP1, CTBP2, and beta EEG.
Title: A genome wide association study of fast beta EEG in families of European ancestry.
MCTP1 was observed on synaptic vesicles in neuronal cell bodies and pre-synaptic axon terminals.
Title: Multiple C2 domains transmembrane protein 1 is expressed in CNS neurons and possibly regulates cellular vesicle retrieval and oxidative stress.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
MCTPs are evolutionarily conserved C2 domain proteins that are unusual in that the C2 domains are anchored in the membrane by two closely spaced transmembrane regions and represent Ca(2+)-binding but not phospholipid-binding modules
Title: Evolutionarily conserved multiple C2 domain proteins with two transmembrane regions (MCTPs) and unusual Ca2+ binding properties.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic variants associated with disordered eating. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

A007H21 (e-PCR)
- UniSTS:11281

SHGC-2934 (e-PCR)
- UniSTS:37419

SHGC-145548 (e-PCR)
- UniSTS:174643

D5S1450 (e-PCR)
- UniSTS:42328

RH120103 (e-PCR)
- UniSTS:132209

SHGC-106024 (e-PCR)
- UniSTS:169596

D5S1628E (e-PCR)
- UniSTS:53131

RH122001 (e-PCR)
- UniSTS:132255

D5S2486 (e-PCR)
- UniSTS:27047

L28355 (e-PCR)
- UniSTS:26030

1790 (e-PCR)
- UniSTS:16052

G19904 (e-PCR)
- UniSTS:49591

A002B42 (e-PCR)
- UniSTS:49592

L28422 (e-PCR)
- UniSTS:14291

RH119208 (e-PCR)
- UniSTS:138717

RH66318 (e-PCR)
- UniSTS:23520

D5S1649E (e-PCR)
- UniSTS:46061

AFM205wg7 (e-PCR)
- UniSTS:14326

D5S2468 (e-PCR)
- UniSTS:21752

SHGC-78910 (e-PCR)
- UniSTS:100856

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
NOT enables calcium-dependent phospholipid binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in calcium-mediated signaling	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of endocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of response to oxidative stress	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of neuronal synaptic plasticity	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of neurotransmitter secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of neurotransmitter secretion	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in recycling endosome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in synaptic vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in synaptic vesicle membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: multiple C2 and transmembrane domain-containing protein 1

Names: multiple C2 domains, transmembrane 1; multiple C2-domains with two transmembrane regions 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002796.5 → NP_001002796.1 multiple C2 and transmembrane domain-containing protein 1 isoform S

See identical proteins and their annotated locations for NP_001002796.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding sequence compared to variant 1. The resulting isoform (S) is shorter and has a distinct N-terminus compared to isoform L.

Source sequence(s)

AC008534, AC012312, AC099507

Consensus CDS

CCDS47247.1

UniProtKB/TrEMBL

D6RA42

Related

ENSP00000308957.8, ENST00000312216.12

Conserved Domains (4) summary

cd04042
Location:41 → 162

C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08376
Location:250 → 365

C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08377
Location:405 → 523

C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

pfam08372
Location:666 → 751

PRT_C; Plant phosphoribosyltransferase C-terminal
NM_001297777.3 → NP_001284706.1 multiple C2 and transmembrane domain-containing protein 1 isoform 3

See identical proteins and their annotated locations for NP_001284706.1

Status: VALIDATED

Source sequence(s)

AC008534, AC012312, AC099507

Consensus CDS

CCDS75275.1

UniProtKB/TrEMBL

D6RA42

Related

ENSP00000391639.2, ENST00000429576.6

Conserved Domains (4) summary

cd04042
Location:41 → 162

C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08376
Location:204 → 319

C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08377
Location:359 → 477

C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

pfam08372
Location:580 → 665

PRT_C; Plant phosphoribosyltransferase C-terminal
NM_001393535.1 → NP_001380464.1 multiple C2 and transmembrane domain-containing protein 1 isoform 4

Status: VALIDATED

Source sequence(s)

AC008534, AC008573, AC012312, AC099507

Conserved Domains (4) summary

cd04042
Location:262 → 383

C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08376
Location:445 → 560

C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08377
Location:600 → 718

C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

pfam08372
Location:861 → 946

PRT_C; Plant phosphoribosyltransferase C-terminal
NM_001393536.1 → NP_001380465.1 multiple C2 and transmembrane domain-containing protein 1 isoform 5

Status: VALIDATED

Source sequence(s)

AC008534, AC008573, AC012312, AC099507

Conserved Domains (4) summary

cd04042
Location:262 → 383

C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08376
Location:425 → 540

C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08377
Location:580 → 698

C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

pfam08372
Location:841 → 926

PRT_C; Plant phosphoribosyltransferase C-terminal
NM_001393537.1 → NP_001380466.1 multiple C2 and transmembrane domain-containing protein 1 isoform 6

Status: VALIDATED

Source sequence(s)

AC008534, AC008573, AC012312, AC099507

Conserved Domains (4) summary

cd04042
Location:262 → 383

C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08376
Location:412 → 527

C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08377
Location:567 → 685

C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

pfam08372
Location:828 → 913

PRT_C; Plant phosphoribosyltransferase C-terminal
NM_001393538.1 → NP_001380467.1 multiple C2 and transmembrane domain-containing protein 1 isoform 7

Status: VALIDATED

Source sequence(s)

AC008534, AC012312, AC099507

UniProtKB/TrEMBL

D6RA42

Conserved Domains (4) summary

cd04042
Location:41 → 162

C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08376
Location:250 → 365

C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08377
Location:405 → 523

C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

pfam08372
Location:666 → 751

PRT_C; Plant phosphoribosyltransferase C-terminal
NM_001393539.1 → NP_001380468.1 multiple C2 and transmembrane domain-containing protein 1 isoform 8

Status: VALIDATED

Source sequence(s)

AC008534, AC012312, AC099507

UniProtKB/TrEMBL

D6RA42

Conserved Domains (4) summary

cd04042
Location:41 → 162

C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08376
Location:224 → 339

C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08377
Location:379 → 497

C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

pfam08372
Location:640 → 725

PRT_C; Plant phosphoribosyltransferase C-terminal
NM_001393540.1 → NP_001380469.1 multiple C2 and transmembrane domain-containing protein 1 isoform 9

Status: VALIDATED

Source sequence(s)

AC008534, AC012312, AC099507

UniProtKB/TrEMBL

D6RA42

Conserved Domains (4) summary

cd04042
Location:41 → 162

C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08376
Location:250 → 365

C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08377
Location:405 → 523

C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

pfam08372
Location:626 → 711

PRT_C; Plant phosphoribosyltransferase C-terminal
NM_001393541.1 → NP_001380470.1 multiple C2 and transmembrane domain-containing protein 1 isoform 10

Status: VALIDATED

Source sequence(s)

AC008534, AC012312, AC099507

UniProtKB/TrEMBL

D6RA42

Conserved Domains (4) summary

cd04042
Location:56 → 177

C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08376
Location:206 → 321

C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08377
Location:361 → 479

C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

pfam08372
Location:622 → 707

PRT_C; Plant phosphoribosyltransferase C-terminal
NM_001393542.1 → NP_001380471.1 multiple C2 and transmembrane domain-containing protein 1 isoform 11

Status: VALIDATED

Source sequence(s)

AC008534, AC012312, AC099507

UniProtKB/TrEMBL

D6RA42

Conserved Domains (4) summary

cd04042
Location:41 → 162

C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08376
Location:204 → 319

C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08377
Location:359 → 477

C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

pfam08372
Location:620 → 705

PRT_C; Plant phosphoribosyltransferase C-terminal
NM_001393543.1 → NP_001380472.1 multiple C2 and transmembrane domain-containing protein 1 isoform 12

Status: VALIDATED

Source sequence(s)

AC008534, AC012312, AC099507

UniProtKB/TrEMBL

D6RA42

Conserved Domains (4) summary

cd04042
Location:41 → 162

C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08376
Location:204 → 319

C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08377
Location:359 → 477

C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

pfam08372
Location:620 → 705

PRT_C; Plant phosphoribosyltransferase C-terminal
NM_001393544.1 → NP_001380473.1 multiple C2 and transmembrane domain-containing protein 1 isoform 13

Status: VALIDATED

Source sequence(s)

AC008534, AC012312, AC099507

UniProtKB/TrEMBL

D6RA42

Conserved Domains (4) summary

cd04042
Location:41 → 162

C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08376
Location:191 → 306

C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08377
Location:346 → 464

C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

pfam08372
Location:607 → 692

PRT_C; Plant phosphoribosyltransferase C-terminal
NM_001393545.1 → NP_001380474.1 multiple C2 and transmembrane domain-containing protein 1 isoform 14

Status: VALIDATED

Source sequence(s)

AC008534, AC012312, AC099507

UniProtKB/TrEMBL

D6RA42

Conserved Domains (4) summary

cd04042
Location:41 → 162

C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08376
Location:189 → 304

C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08377
Location:344 → 462

C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

pfam08372
Location:605 → 690

PRT_C; Plant phosphoribosyltransferase C-terminal
NM_001393546.1 → NP_001380475.1 multiple C2 and transmembrane domain-containing protein 1 isoform 15

Status: VALIDATED

Source sequence(s)

AC008534, AC012312, AC099507

UniProtKB/TrEMBL

D6RA42

Conserved Domains (4) summary

cd04042
Location:41 → 162

C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08376
Location:217 → 332

C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08377
Location:372 → 490

C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

pfam08372
Location:593 → 678

PRT_C; Plant phosphoribosyltransferase C-terminal
NM_001393547.1 → NP_001380476.1 multiple C2 and transmembrane domain-containing protein 1 isoform 16

Status: VALIDATED

Source sequence(s)

AC008534, AC012312, AC099507

UniProtKB/TrEMBL

D6RA42

Conserved Domains (4) summary

cd04042
Location:41 → 162

C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08376
Location:211 → 326

C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08377
Location:366 → 484

C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

pfam08372
Location:587 → 672

PRT_C; Plant phosphoribosyltransferase C-terminal
NM_001393548.1 → NP_001380477.1 multiple C2 and transmembrane domain-containing protein 1 isoform 17

Status: VALIDATED

Source sequence(s)

AC008534, AC012312, AC099507

UniProtKB/TrEMBL

D6RA42

Conserved Domains (4) summary

cd04042
Location:41 → 162

C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08376
Location:204 → 319

C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08377
Location:359 → 477

C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

pfam08372
Location:580 → 636

PRT_C; Plant phosphoribosyltransferase C-terminal
NM_001393549.1 → NP_001380478.1 multiple C2 and transmembrane domain-containing protein 1 isoform 18

Status: VALIDATED

Source sequence(s)

AC008534, AC012312, AC099507

Consensus CDS

CCDS93747.1

Related

ENSP00000426438.1, ENST00000505208.5

Conserved Domains (3) summary

cd04042
Location:41 → 162

C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08376
Location:250 → 365

C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08377
Location:405 → 523

C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
NM_001393550.1 → NP_001380479.1 multiple C2 and transmembrane domain-containing protein 1 isoform 19

Status: VALIDATED

Source sequence(s)

AC008534, AC012312, AC099507

Conserved Domains (3) summary

cd04042
Location:41 → 162

C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08376
Location:204 → 319

C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08377
Location:359 → 448

C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
NM_001393551.1 → NP_001380480.1 multiple C2 and transmembrane domain-containing protein 1 isoform 20

Status: VALIDATED

Source sequence(s)

AC008534, AC012312, AC099507

Conserved Domains (2) summary

cd04042
Location:41 → 162

C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

pfam08372
Location:205 → 290

PRT_C; Plant phosphoribosyltransferase C-terminal
NM_024717.7 → NP_078993.4 multiple C2 and transmembrane domain-containing protein 1 isoform L

See identical proteins and their annotated locations for NP_078993.4

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (L).

Source sequence(s)

AC008534, AC008573, AC012312, AC099507

Consensus CDS

CCDS34203.1

UniProtKB/Swiss-Prot

Q6DN13, Q6DN14, Q8N2W1, Q8NBA2, Q96LX0, Q9H6E8

Related

ENSP00000424126.1, ENST00000515393.6

Conserved Domains (4) summary

cd04042
Location:262 → 383

C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08376
Location:471 → 586

C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08377
Location:626 → 744

C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

pfam08372
Location:887 → 972

PRT_C; Plant phosphoribosyltransferase C-terminal

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000005.10 Reference GRCh38.p14 Primary Assembly

Range

94703690..95285094 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047417718.1 → XP_047273674.1 multiple C2 and transmembrane domain-containing protein 1 isoform X11
XM_047417715.1 → XP_047273671.1 multiple C2 and transmembrane domain-containing protein 1 isoform X8
XM_017009858.3 → XP_016865347.2 multiple C2 and transmembrane domain-containing protein 1 isoform X3
XM_017009855.3 → XP_016865344.2 multiple C2 and transmembrane domain-containing protein 1 isoform X2
XM_047417716.1 → XP_047273672.1 multiple C2 and transmembrane domain-containing protein 1 isoform X9
XM_047417713.1 → XP_047273669.1 multiple C2 and transmembrane domain-containing protein 1 isoform X6
XM_047417714.1 → XP_047273670.1 multiple C2 and transmembrane domain-containing protein 1 isoform X7
XM_047417712.1 → XP_047273668.1 multiple C2 and transmembrane domain-containing protein 1 isoform X5
XM_017009859.2 → XP_016865348.2 multiple C2 and transmembrane domain-containing protein 1 isoform X4
XM_047417711.1 → XP_047273667.1 multiple C2 and transmembrane domain-containing protein 1 isoform X1
XM_047417738.1 → XP_047273694.1 multiple C2 and transmembrane domain-containing protein 1 isoform X32
XM_047417737.1 → XP_047273693.1 multiple C2 and transmembrane domain-containing protein 1 isoform X31
XM_047417731.1 → XP_047273687.1 multiple C2 and transmembrane domain-containing protein 1 isoform X25
XM_047417735.1 → XP_047273691.1 multiple C2 and transmembrane domain-containing protein 1 isoform X29
XM_047417729.1 → XP_047273685.1 multiple C2 and transmembrane domain-containing protein 1 isoform X23
XM_047417728.1 → XP_047273684.1 multiple C2 and transmembrane domain-containing protein 1 isoform X22
XM_047417730.1 → XP_047273686.1 multiple C2 and transmembrane domain-containing protein 1 isoform X24
XM_047417725.1 → XP_047273681.1 multiple C2 and transmembrane domain-containing protein 1 isoform X18
XM_047417736.1 → XP_047273692.1 multiple C2 and transmembrane domain-containing protein 1 isoform X30
XM_047417733.1 → XP_047273689.1 multiple C2 and transmembrane domain-containing protein 1 isoform X27
XM_047417732.1 → XP_047273688.1 multiple C2 and transmembrane domain-containing protein 1 isoform X26
XM_047417726.1 → XP_047273682.1 multiple C2 and transmembrane domain-containing protein 1 isoform X19
XM_011543649.4 → XP_011541951.1 multiple C2 and transmembrane domain-containing protein 1 isoform X21

UniProtKB/TrEMBL

D6RA42

Conserved Domains (4) summary

cd04042
Location:3 → 124

C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08376
Location:212 → 327

C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08377
Location:367 → 485

C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

pfam08372
Location:628 → 713

PRT_C; Plant phosphoribosyltransferase C-terminal
XM_047417734.1 → XP_047273690.1 multiple C2 and transmembrane domain-containing protein 1 isoform X28
XM_047417727.1 → XP_047273683.1 multiple C2 and transmembrane domain-containing protein 1 isoform X20
XM_047417724.1 → XP_047273680.1 multiple C2 and transmembrane domain-containing protein 1 isoform X17
XM_005272082.6 → XP_005272139.1 multiple C2 and transmembrane domain-containing protein 1 isoform X16

UniProtKB/TrEMBL

D6RA42

Conserved Domains (4) summary

cd04042
Location:56 → 177

C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08376
Location:265 → 380

C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08377
Location:420 → 538

C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

pfam08372
Location:681 → 766

PRT_C; Plant phosphoribosyltransferase C-terminal
XM_011543650.3 → XP_011541952.1 multiple C2 and transmembrane domain-containing protein 1 isoform X35

UniProtKB/TrEMBL

D6RA42

Conserved Domains (4) summary

cd08376
Location:132 → 247

C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08377
Location:287 → 405

C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

pfam08372
Location:548 → 633

PRT_C; Plant phosphoribosyltransferase C-terminal

cl14603
Location:1 → 44

C2; C2 domain
XM_047417742.1 → XP_047273698.1 multiple C2 and transmembrane domain-containing protein 1 isoform X36

Related

ENSP00000423410.1, ENST00000508509.5
XM_047417741.1 → XP_047273697.1 multiple C2 and transmembrane domain-containing protein 1 isoform X34
XM_047417720.1 → XP_047273676.1 multiple C2 and transmembrane domain-containing protein 1 isoform X13
XM_047417717.1 → XP_047273673.1 multiple C2 and transmembrane domain-containing protein 1 isoform X10
XM_047417719.1 → XP_047273675.1 multiple C2 and transmembrane domain-containing protein 1 isoform X12
XM_047417739.1 → XP_047273695.1 multiple C2 and transmembrane domain-containing protein 1 isoform X33
XM_047417722.1 → XP_047273678.1 multiple C2 and transmembrane domain-containing protein 1 isoform X14
XM_047417723.1 → XP_047273679.1 multiple C2 and transmembrane domain-containing protein 1 isoform X15

Alternate T2T-CHM13v2.0

Genomic

NC_060929.1 Alternate T2T-CHM13v2.0

Range

95188075..95786099 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054353470.1 → XP_054209445.1 multiple C2 and transmembrane domain-containing protein 1 isoform X11
XM_054353467.1 → XP_054209442.1 multiple C2 and transmembrane domain-containing protein 1 isoform X8
XM_054353462.1 → XP_054209437.1 multiple C2 and transmembrane domain-containing protein 1 isoform X3
XM_054353461.1 → XP_054209436.1 multiple C2 and transmembrane domain-containing protein 1 isoform X2
XM_054353468.1 → XP_054209443.1 multiple C2 and transmembrane domain-containing protein 1 isoform X9
XM_054353465.1 → XP_054209440.1 multiple C2 and transmembrane domain-containing protein 1 isoform X6
XM_054353466.1 → XP_054209441.1 multiple C2 and transmembrane domain-containing protein 1 isoform X7
XM_054353464.1 → XP_054209439.1 multiple C2 and transmembrane domain-containing protein 1 isoform X5
XM_054353463.1 → XP_054209438.1 multiple C2 and transmembrane domain-containing protein 1 isoform X4
XM_054353460.1 → XP_054209435.1 multiple C2 and transmembrane domain-containing protein 1 isoform X1
XM_054353491.1 → XP_054209466.1 multiple C2 and transmembrane domain-containing protein 1 isoform X32
XM_054353490.1 → XP_054209465.1 multiple C2 and transmembrane domain-containing protein 1 isoform X31
XM_054353484.1 → XP_054209459.1 multiple C2 and transmembrane domain-containing protein 1 isoform X25
XM_054353488.1 → XP_054209463.1 multiple C2 and transmembrane domain-containing protein 1 isoform X29
XM_054353482.1 → XP_054209457.1 multiple C2 and transmembrane domain-containing protein 1 isoform X23
XM_054353481.1 → XP_054209456.1 multiple C2 and transmembrane domain-containing protein 1 isoform X22
XM_054353483.1 → XP_054209458.1 multiple C2 and transmembrane domain-containing protein 1 isoform X24
XM_054353477.1 → XP_054209452.1 multiple C2 and transmembrane domain-containing protein 1 isoform X18
XM_054353489.1 → XP_054209464.1 multiple C2 and transmembrane domain-containing protein 1 isoform X30
XM_054353486.1 → XP_054209461.1 multiple C2 and transmembrane domain-containing protein 1 isoform X27
XM_054353485.1 → XP_054209460.1 multiple C2 and transmembrane domain-containing protein 1 isoform X26
XM_054353478.1 → XP_054209453.1 multiple C2 and transmembrane domain-containing protein 1 isoform X19
XM_054353480.1 → XP_054209455.1 multiple C2 and transmembrane domain-containing protein 1 isoform X21
XM_054353487.1 → XP_054209462.1 multiple C2 and transmembrane domain-containing protein 1 isoform X28
XM_054353479.1 → XP_054209454.1 multiple C2 and transmembrane domain-containing protein 1 isoform X20
XM_054353476.1 → XP_054209451.1 multiple C2 and transmembrane domain-containing protein 1 isoform X17
XM_054353475.1 → XP_054209450.1 multiple C2 and transmembrane domain-containing protein 1 isoform X16
XM_054353494.1 → XP_054209469.1 multiple C2 and transmembrane domain-containing protein 1 isoform X35
XM_054353495.1 → XP_054209470.1 multiple C2 and transmembrane domain-containing protein 1 isoform X36
XM_054353493.1 → XP_054209468.1 multiple C2 and transmembrane domain-containing protein 1 isoform X34
XM_054353472.1 → XP_054209447.1 multiple C2 and transmembrane domain-containing protein 1 isoform X13
XM_054353469.1 → XP_054209444.1 multiple C2 and transmembrane domain-containing protein 1 isoform X10
XM_054353471.1 → XP_054209446.1 multiple C2 and transmembrane domain-containing protein 1 isoform X12
XM_054353492.1 → XP_054209467.1 multiple C2 and transmembrane domain-containing protein 1 isoform X33
XM_054353473.1 → XP_054209448.1 multiple C2 and transmembrane domain-containing protein 1 isoform X14
XM_054353474.1 → XP_054209449.1 multiple C2 and transmembrane domain-containing protein 1 isoform X15