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ZDHHC11 zinc finger DHHC-type containing 11 [ Homo sapiens (human) ]

Gene ID: 79844, updated on 30-Apr-2024

Summary

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Official Symbol
ZDHHC11provided by HGNC
Official Full Name
zinc finger DHHC-type containing 11provided by HGNC
Primary source
HGNC:HGNC:19158
See related
Ensembl:ENSG00000188818 AllianceGenome:HGNC:19158
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF399
Summary
Enables signaling adaptor activity. Involved in antiviral innate immune response and positive regulation of defense response to virus by host. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung (RPKM 2.8), duodenum (RPKM 2.5) and 24 other tissues See more
Orthologs
all
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Genomic context

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See ZDHHC11 in Genome Data Viewer
Location:
5p15.33
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (795605..860563, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (701646..766615, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (795720..851101, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene tubulin polymerization promoting protein Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15876 Neighboring gene uncharacterized LOC101929898 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:694389-695267 Neighboring gene NANOG hESC enhancer GRCh37_chr5:708729-709282 Neighboring gene zinc finger DHHC-type containing 11B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:727349-727849 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:752062-752252 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:753615-754114 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22299 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22300 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22301 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:758511-759354 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:759355-760198 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:771879-772522 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86882 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:782879-783538 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:785123-785861 Neighboring gene bromodomain containing 9 pseudogene 2 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:794321-795181 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:811555-811724 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:827809-828355 Neighboring gene signal peptidase complex subunit 2 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22302 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:849793-850444 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:850445-851094 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:892285-892917 Neighboring gene bromodomain containing 9 Neighboring gene Sharpr-MPRA regulatory region 1606 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:916909-917478 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:918895-919438 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:919439-919982 Neighboring gene thyroid hormone receptor interactor 13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ZDHHC11 and ZDHHC11B are critical novel components of the oncogenic MYC-miR-150-MYB network in Burkitt lymphoma. Dzikiewicz-Krawczyk A, et al. Leukemia, 2017 Jun. PMID 28331227
  2. Gain of 5p15.33 is associated with progression of bladder cancer. Yamamoto Y, et al. Oncology, 2007. PMID 18025801
  3. ZDHHC11 Positively Regulates NF-κB Activation by Enhancing TRAF6 Oligomerization. Liu E, et al. Front Cell Dev Biol, 2021. PMID 34490261, Free PMC Article
  4. ZDHHC11 modulates innate immune response to DNA virus by mediating MITA-IRF3 association. Liu Y, et al. Cell Mol Immunol, 2018 Oct. PMID 29429998, Free PMC Article
  5. In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes. Oku S, et al. J Biol Chem, 2013 Jul 5. PMID 23687301, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Circular ZDHHC11 supports Burkitt lymphoma growth independent of its miR-150 binding capacity.
    Title: Circular ZDHHC11 supports Burkitt lymphoma growth independent of its miR-150 binding capacity.
  2. First, MYC downregulates miR-150 to unleash MYB from the miR-150-mediated repression. Second, MYC induces ZDHHC11 and ZDHHC11B that further ensures the maintenance of high MYB levels
    Title: ZDHHC11 and ZDHHC11B are critical novel components of the oncogenic MYC-miR-150-MYB network in Burkitt lymphoma.
  3. ZDHHC11 and ZDHHC11B are novel targets of miR-150 with a key role in maintaining elevated levels of the MYB oncogene required for the high proliferation rate of Burkitt lymphoma cells.
    Title: ZDHHC11 and ZDHHC11B are critical novel components of the oncogenic MYC-miR-150-MYB network in Burkitt lymphoma.
  4. In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes.
    Title: In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes.
  5. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  6. data suggest that gain of 5p15.33 (TPPP and ZDHHC11) may become a potential biomarker identifying high-risk patients with disease progression in bladder cancer.
    Title: Gain of 5p15.33 is associated with progression of bladder cancer.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ13153

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-cysteine S-palmitoyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables signaling adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in antiviral innate immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peptidyl-L-cysteine S-palmitoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-L-cysteine S-palmitoylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of defense response to virus by host IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane TAS
Traceable Author Statement
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
palmitoyltransferase ZDHHC11
Names
DHHC-11
probable palmitoyltransferase ZDHHC11
zinc finger DHHC domain-containing protein 11
zinc finger protein 399
zinc finger, DHHC domain containing 11
NP_001380421.1
NP_079062.1
XP_024301977.1
XP_024301978.1
XP_024301980.1
XP_024301981.1
XP_024301982.1
XP_024301983.1
XP_024301984.1
XP_024301985.1
XP_024301986.1
XP_047273702.1
XP_047273703.1
XP_047273704.1
XP_047273705.1
XP_047273706.1
XP_047273707.1
XP_047273708.1
XP_047273709.1
XP_047273710.1
XP_047273711.1
XP_047273712.1
XP_047273713.1
XP_047273714.1
XP_047273715.1
XP_047273716.1
XP_047273717.1
XP_047273718.1
XP_054209475.1
XP_054209476.1
XP_054209477.1
XP_054209478.1
XP_054209479.1
XP_054209480.1
XP_054209481.1
XP_054209482.1
XP_054209483.1
XP_054209484.1
XP_054209485.1
XP_054209486.1
XP_054209487.1
XP_054209488.1
XP_054209489.1
XP_054209490.1
XP_054209491.1
XP_054209492.1
XP_054209493.1
XP_054209494.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001393492.1 → NP_001380421.1  palmitoyltransferase ZDHHC11 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC010427, AC026740, AC122719
    Conserved Domains (1) summary
    pfam01529
    Location:193 → 330
    DHHC; DHHC palmitoyltransferase

  2. NM_024786.3 → NP_079062.1  palmitoyltransferase ZDHHC11 isoform 2

    See identical proteins and their annotated locations for NP_079062.1

    Status: VALIDATED

    Source sequence(s)
    AC010427, AC026740, AC122719
    Consensus CDS
    CCDS3857.1
    UniProtKB/Swiss-Prot
    Q6UWR9, Q9H8X9
    Related
    ENSP00000283441.8, ENST00000283441.13
    Conserved Domains (1) summary
    pfam01529
    Location:120 → 275
    zf-DHHC; DHHC palmitoyltransferase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    795605..860563 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047417747.1 → XP_047273703.1  palmitoyltransferase ZDHHC11 isoform X1

  2. XM_047417746.1 → XP_047273702.1  palmitoyltransferase ZDHHC11 isoform X1

  3. XM_024446212.2 → XP_024301980.1  palmitoyltransferase ZDHHC11 isoform X5

    UniProtKB/Swiss-Prot
    Q6UWR9, Q9H8X9
    Conserved Domains (1) summary
    pfam01529
    Location:120 → 275
    zf-DHHC; DHHC palmitoyltransferase

  4. XM_047417749.1 → XP_047273705.1  palmitoyltransferase ZDHHC11 isoform X4

  5. XM_024446210.2 → XP_024301978.1  palmitoyltransferase ZDHHC11 isoform X3

    Conserved Domains (1) summary
    pfam01529
    Location:193 → 330
    DHHC; DHHC palmitoyltransferase

  6. XM_024446209.2 → XP_024301977.1  palmitoyltransferase ZDHHC11 isoform X1

    Conserved Domains (1) summary
    pfam01529
    Location:193 → 316
    zf-DHHC; DHHC palmitoyltransferase

  7. XM_047417762.1 → XP_047273718.1  palmitoyltransferase ZDHHC11 isoform X21

  8. XM_047417761.1 → XP_047273717.1  palmitoyltransferase ZDHHC11 isoform X21

  9. XM_047417758.1 → XP_047273714.1  palmitoyltransferase ZDHHC11 isoform X20

  10. XM_047417760.1 → XP_047273716.1  palmitoyltransferase ZDHHC11 isoform X22

  11. XM_047417759.1 → XP_047273715.1  palmitoyltransferase ZDHHC11 isoform X21

    Related
    ENST00000503758.6

  12. XM_047417748.1 → XP_047273704.1  palmitoyltransferase ZDHHC11 isoform X2

  13. XM_047417754.1 → XP_047273710.1  palmitoyltransferase ZDHHC11 isoform X12

  14. XM_047417752.1 → XP_047273708.1  palmitoyltransferase ZDHHC11 isoform X9

  15. XM_047417755.1 → XP_047273711.1  palmitoyltransferase ZDHHC11 isoform X15

  16. XM_047417753.1 → XP_047273709.1  palmitoyltransferase ZDHHC11 isoform X11

  17. XM_047417751.1 → XP_047273707.1  palmitoyltransferase ZDHHC11 isoform X7

  18. XM_047417756.1 → XP_047273712.1  palmitoyltransferase ZDHHC11 isoform X17

  19. XM_024446214.2 → XP_024301982.1  palmitoyltransferase ZDHHC11 isoform X10

    Conserved Domains (1) summary
    pfam01529
    Location:193 → 263
    zf-DHHC; DHHC palmitoyltransferase

  20. XM_047417750.1 → XP_047273706.1  palmitoyltransferase ZDHHC11 isoform X6

  21. XM_024446216.2 → XP_024301984.1  palmitoyltransferase ZDHHC11 isoform X14

    Conserved Domains (1) summary
    pfam01529
    Location:193 → 261
    zf-DHHC; DHHC palmitoyltransferase

  22. XM_024446213.2 → XP_024301981.1  palmitoyltransferase ZDHHC11 isoform X8

    Conserved Domains (1) summary
    pfam01529
    Location:193 → 261
    zf-DHHC; DHHC palmitoyltransferase

  23. XM_047417757.1 → XP_047273713.1  palmitoyltransferase ZDHHC11 isoform X19

  24. XM_024446215.2 → XP_024301983.1  palmitoyltransferase ZDHHC11 isoform X13

    Conserved Domains (1) summary
    pfam01529
    Location:193 → 254
    zf-DHHC; DHHC palmitoyltransferase

  25. XM_024446217.2 → XP_024301985.1  palmitoyltransferase ZDHHC11 isoform X16

    Conserved Domains (1) summary
    cl19890
    Location:193 → 245
    zf-DHHC; DHHC palmitoyltransferase

  26. XM_024446218.2 → XP_024301986.1  palmitoyltransferase ZDHHC11 isoform X18

    Conserved Domains (1) summary
    cl19890
    Location:193 → 245
    zf-DHHC; DHHC palmitoyltransferase

RNA

  1. XR_007058638.1 RNA Sequence

  2. XR_007058637.1 RNA Sequence

  3. XR_007058640.1 RNA Sequence

  4. XR_007058639.1 RNA Sequence

  5. XR_007058636.1 RNA Sequence

  6. XR_007058641.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    701646..766615 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054353502.1 → XP_054209477.1  palmitoyltransferase ZDHHC11 isoform X1

  2. XM_054353501.1 → XP_054209476.1  palmitoyltransferase ZDHHC11 isoform X1

  3. XM_054353506.1 → XP_054209481.1  palmitoyltransferase ZDHHC11 isoform X5

    UniProtKB/Swiss-Prot
    Q6UWR9, Q9H8X9

  4. XM_054353505.1 → XP_054209480.1  palmitoyltransferase ZDHHC11 isoform X4

  5. XM_054353504.1 → XP_054209479.1  palmitoyltransferase ZDHHC11 isoform X3

  6. XM_054353500.1 → XP_054209475.1  palmitoyltransferase ZDHHC11 isoform X1

  7. XM_054353512.1 → XP_054209487.1  palmitoyltransferase ZDHHC11 isoform X23

  8. XM_054353519.1 → XP_054209494.1  palmitoyltransferase ZDHHC11 isoform X21

  9. XM_054353518.1 → XP_054209493.1  palmitoyltransferase ZDHHC11 isoform X21

  10. XM_054353516.1 → XP_054209491.1  palmitoyltransferase ZDHHC11 isoform X20

  11. XM_054353517.1 → XP_054209492.1  palmitoyltransferase ZDHHC11 isoform X22

  12. XM_054353503.1 → XP_054209478.1  palmitoyltransferase ZDHHC11 isoform X2

  13. XM_054353508.1 → XP_054209483.1  palmitoyltransferase ZDHHC11 isoform X12

  14. XM_054353511.1 → XP_054209486.1  palmitoyltransferase ZDHHC11 isoform X15

  15. XM_054353507.1 → XP_054209482.1  palmitoyltransferase ZDHHC11 isoform X6

  16. XM_054353510.1 → XP_054209485.1  palmitoyltransferase ZDHHC11 isoform X14

  17. XM_054353515.1 → XP_054209490.1  palmitoyltransferase ZDHHC11 isoform X19

  18. XM_054353509.1 → XP_054209484.1  palmitoyltransferase ZDHHC11 isoform X13

  19. XM_054353513.1 → XP_054209488.1  palmitoyltransferase ZDHHC11 isoform X16

  20. XM_054353514.1 → XP_054209489.1  palmitoyltransferase ZDHHC11 isoform X18

RNA

  1. XR_008487166.1 RNA Sequence

  2. XR_008487165.1 RNA Sequence

  3. XR_008487167.1 RNA Sequence

  4. XR_008487164.1 RNA Sequence

  5. XR_008487169.1 RNA Sequence

  6. XR_008487168.1 RNA Sequence

  7. XR_008487171.1 RNA Sequence

  8. XR_008487173.1 RNA Sequence

  9. XR_008487172.1 RNA Sequence

  10. XR_008487170.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H8X9.1 GenPept UniProtKB/Swiss-Prot:Q9H8X9

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