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ALG13 ALG13 UDP-N-acetylglucosaminyltransferase subunit [ Homo sapiens (human) ]

Gene ID: 79868, updated on 3-Apr-2024

Summary

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Official Symbol
ALG13provided by HGNC
Official Full Name
ALG13 UDP-N-acetylglucosaminyltransferase subunitprovided by HGNC
Primary source
HGNC:HGNC:30881
See related
Ensembl:ENSG00000101901 MIM:300776; AllianceGenome:HGNC:30881
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CDG1S; DEE36; EIEE36; MDS031; TDRD13; CXorf45; GLT28D1; YGL047W
Summary
The protein encoded by this gene is a subunit of a bipartite UDP-N-acetylglucosamine transferase. It heterodimerizes with asparagine-linked glycosylation 14 homolog to form a functional UDP-GlcNAc glycosyltransferase that catalyzes the second sugar addition of the highly conserved oligosaccharide precursor in endoplasmic reticulum N-linked glycosylation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
Expression
Ubiquitous expression in testis (RPKM 4.1), skin (RPKM 3.5) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
Xq23
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (111681170..111760649)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (110129414..110208990)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (110924398..111003877)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L18a pseudogene 15 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:110924066-110924785 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29860 Neighboring gene RNA, 5S ribosomal pseudogene 512 Neighboring gene transient receptor potential cation channel subfamily C member 5 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20944 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:111155775-111156274 Neighboring gene TRPC5 opposite strand Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29861 Neighboring gene retrotransposon Gag like 4 Neighboring gene divergent-paired related homeobox pseudogene 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ALG13 X-linked intellectual disability: New variants, glycosylation analysis, and expanded phenotypes. Alsharhan H, et al. J Inherit Metab Dis, 2021 Jul. PMID 33734437, Free PMC Article
  2. Expanding the phenotype, genotype and biochemical knowledge of ALG3-CDG. Alsharhan H, et al. J Inherit Metab Dis, 2021 Jul. PMID 33583022, Free PMC Article
  3. The phenotypic spectrum of X-linked, infantile onset ALG13-related developmental and epileptic encephalopathy. Datta AN, et al. Epilepsia, 2021 Feb. PMID 33410528, Free PMC Article
  4. X-Linked ALG13 Gene Variant as a Cause of Epileptic Encephalopathy in Girls. Madaan P, et al. Indian J Pediatr, 2019 Nov. PMID 31444733
  5. Exome sequence identified a c.320A > G ALG13 variant in a female with infantile epileptic encephalopathy with normal glycosylation and random X inactivation: Review of the literature. Hamici S, et al. Eur J Med Genet, 2017 Oct. PMID 28778787

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ALG13 X-linked intellectual disability: New variants, glycosylation analysis, and expanded phenotypes.
    Title: ALG13 X-linked intellectual disability: New variants, glycosylation analysis, and expanded phenotypes.
  2. Expanding the phenotype, genotype and biochemical knowledge of ALG3-CDG.
    Title: Expanding the phenotype, genotype and biochemical knowledge of ALG3-CDG.
  3. The phenotypic spectrum of X-linked, infantile onset ALG13-related developmental and epileptic encephalopathy.
    Title: The phenotypic spectrum of X-linked, infantile onset ALG13-related developmental and epileptic encephalopathy.
  4. X-Linked ALG13 Gene Variant as a Cause of Epileptic Encephalopathy in Girls.
    Title: X-Linked ALG13 Gene Variant as a Cause of Epileptic Encephalopathy in Girls.
  5. ALG13-is2 could be an important modifier of renal filtration defects
    Title: Dysregulation of the Expression of Asparagine-Linked Glycosylation 13 Short Isoform 2 Affects Nephrin Function by Altering Its N-Linked Glycosylation.
  6. A female patient heterozygous for ALG13 Asn107Ser variant presented with infantile spasms, developmental delay, and dysmorphic features. The patient showed normal pattern of glycosylated transferrin and random pattern of X-inactivation.
    Title: Exome sequence identified a c.320A > G ALG13 variant in a female with infantile epileptic encephalopathy with normal glycosylation and random X inactivation: Review of the literature.
  7. We report on a novel missense variant in the ALG13 gene in a nonconsanguineous Arab family that co-segregates with nonsyndromic intellectual disability.
    Title: X chromosome exome sequencing reveals a novel ALG13 mutation in a nonsyndromic intellectual disability family with multiple affected male siblings.
  8. ALG13 and ALG14 form a functional endoplasmic reticulum UDP-N-acetylglucosamine transferase
    Title: Alg14 recruits Alg13 to the cytoplasmic face of the endoplasmic reticulum to form a novel bipartite UDP-N-acetylglucosamine transferase required for the second step of N-linked glycosylation.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Addition of peripheral sugar residues such as galactose, N-acetylglucosamine, and sialic acid to HIV-1 gp120 is processed by specific glycosyltransferase PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ23018, FLJ31785, MGC12423

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding HDA PubMed 
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in dolichol-linked oligosaccharide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13
Names
N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase
UDP-N-acetylglucosamine transferase subunit ALG13 homolog
asparagine-linked glycosylation 13 homolog
glycosyltransferase 28 domain-containing protein 1
hematopoietic stem/progenitor cells protein MDS031
tudor domain containing 13
NP_001034299.3
NP_001093392.1
NP_001161857.1
NP_001244159.1
NP_001244160.1
NP_001244163.1
NP_001244164.1
NP_001244166.1
NP_001244168.1
NP_001244169.1
NP_001244170.1
NP_001311219.1
NP_001311220.1
NP_001311221.1
NP_001311222.1
NP_001311223.1
NP_060936.1
XP_006724756.1
XP_006724760.2
XP_006724761.2
XP_011529330.1
XP_011529332.1
XP_011529333.1
XP_011529334.1
XP_011529335.1
XP_011529336.1
XP_016885335.1
XP_016885336.1
XP_016885337.1
XP_016885338.1
XP_016885339.1
XP_016885341.1
XP_024308217.1
XP_047298476.1
XP_047298477.1
XP_047298478.1
XP_047298479.1
XP_047298480.1
XP_047298481.1
XP_047298482.1
XP_047298483.1
XP_047298484.1
XP_047298485.1
XP_047298486.1
XP_047298487.1
XP_054183853.1
XP_054183854.1
XP_054183855.1
XP_054183856.1
XP_054183857.1
XP_054183858.1
XP_054183859.1
XP_054183860.1
XP_054183861.1
XP_054183862.1
XP_054183863.1
XP_054183864.1
XP_054183865.1
XP_054183866.1
XP_054183867.1
XP_054183868.1
XP_054183869.1
XP_054183870.1
XP_054183871.1
XP_054183872.1
XP_054183873.1
XP_054183874.1
XP_054183875.1
XP_054183876.1
XP_054183877.1
XP_054183878.1
XP_054183879.1
XP_054183880.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016238.1 RefSeqGene

    Range
    5053..84532
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001039210.5 → NP_001034299.3  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform 3

    See identical proteins and their annotated locations for NP_001034299.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and has multiple differences in the coding region, compared to variant 1. The resulting isoform (3) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK056347, AL096764, BC005336, BF699152, BQ007420
    UniProtKB/TrEMBL
    A0A096LNL2
    Conserved Domains (1) summary
    cl10013
    Location:4 → 48
    Glycosyltransferase_GTB-type; glycosyltransferase family 1 and related proteins with GTB topology

  2. NM_001099922.3 → NP_001093392.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform 1

    See identical proteins and their annotated locations for NP_001093392.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK302729, AK304712, BF699152, BQ015240, DB516751
    Consensus CDS
    CCDS55477.1
    UniProtKB/Swiss-Prot
    B1AKD6, B1AKM1, B2R5L5, B7Z6J0, B7Z804, B7Z847, B7Z9A8, B7ZAJ1, B7ZB57, Q17RC3, Q5JXY9, Q9H5U8, Q9NP73
    UniProtKB/TrEMBL
    A0A096LPI3
    Related
    ENSP00000378260.3, ENST00000394780.8
    Conserved Domains (3) summary
    cd04508
    Location:496 → 544
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    cl10013
    Location:4 → 120
    Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...
    cl19932
    Location:239 → 345
    OTU; OTU-like cysteine protease

  3. NM_001168385.3 → NP_001161857.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform 4

    See identical proteins and their annotated locations for NP_001161857.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 3' UTR and 3' coding region, compared to variant 1. The resulting isoform (4) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK056347, AL096764, BC005336, BE747995, BF699152
    Consensus CDS
    CCDS76011.1
    UniProtKB/TrEMBL
    A0A087WX43, A0A096LNJ4
    Related
    ENSP00000480711.1, ENST00000473389.5
    Conserved Domains (1) summary
    cl10013
    Location:4 → 131
    Glycosyltransferase_GTB-type; glycosyltransferase family 1 and related proteins with GTB topology

  4. NM_001257230.2 → NP_001244159.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform 5

    See identical proteins and their annotated locations for NP_001244159.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in the 5' region, initiates translation at a downstream, in-frame start codon and lacks an exon in the 3' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
    Source sequence(s)
    AK026671, AK300394, AK316522, BF699152, BQ015240
    Consensus CDS
    CCDS59173.1
    UniProtKB/TrEMBL
    A0A096LPI3
    Related
    ENSP00000392990.2, ENST00000436609.5
    Conserved Domains (2) summary
    cd04508
    Location:392 → 440
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    cl19932
    Location:135 → 241
    OTU; OTU-like cysteine protease

  5. NM_001257231.2 → NP_001244160.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform 6

    See identical proteins and their annotated locations for NP_001244160.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, initiates translation at an alternate start codon and uses an alternate splice site in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (6) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK026671, AK302890, BP344481, BQ015240, DB292609
    UniProtKB/TrEMBL
    A0A096LPI3
    Conserved Domains (3) summary
    cd04508
    Location:418 → 466
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    cl10013
    Location:4 → 42
    Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...
    cl19932
    Location:161 → 267
    OTU; OTU-like cysteine protease

  6. NM_001257234.2 → NP_001244163.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform 5

    See identical proteins and their annotated locations for NP_001244163.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) has multiple differences, compared to variant 1, including the use of a downstream, in-frame start codon. Variants 5, 8 and 10 encode the same isoform (5), which is shorter than isoform 1.
    Source sequence(s)
    AK026671, AK316306, AK316522, BQ015240, DB292609
    Consensus CDS
    CCDS59173.1
    UniProtKB/TrEMBL
    A0A096LPI3
    Conserved Domains (2) summary
    cd04508
    Location:392 → 440
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    cl19932
    Location:135 → 241
    OTU; OTU-like cysteine protease

  7. NM_001257235.3 → NP_001244164.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform 7

    See identical proteins and their annotated locations for NP_001244164.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) has multiple differences, compared to variant 1, including the use of a downstream, in-frame start codon and alternate 3' UTR. Variants 9, 11 and 12 encode the same isoform (7) which is significantly shorter and has a unique C-terminus, compared to isoform 1.
    Source sequence(s)
    AL096764, CB268871, DB292609
    Consensus CDS
    CCDS76013.1
    UniProtKB/TrEMBL
    A0A087WT15

  8. NM_001257237.2 → NP_001244166.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform 5

    See identical proteins and their annotated locations for NP_001244166.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR, initiates translation at a downstream, in-frame start codon and lacks an exon in the 3' coding region, but maintains the reading frame, compared to variant 1. Variants 5, 8 and 10 encode the same isoform (5), which is shorter than isoform 1.
    Source sequence(s)
    AK026671, AK316522, BQ015240, DB292609
    Consensus CDS
    CCDS59173.1
    UniProtKB/TrEMBL
    A0A096LPI3
    Conserved Domains (2) summary
    cd04508
    Location:392 → 440
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    cl19932
    Location:135 → 241
    OTU; OTU-like cysteine protease

  9. NM_001257239.3 → NP_001244168.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform 7

    See identical proteins and their annotated locations for NP_001244168.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) has multiple differences, compared to variant 1, including the use of a downstream, in-frame start codon and alternate 3' UTR. Variants 9, 11 and 12 encode the same isoform (7) which is significantly shorter and has a unique C-terminus, compared to isoform 1.
    Source sequence(s)
    AL096764, BG621042, BM759764, DC400909
    Consensus CDS
    CCDS76013.1
    UniProtKB/TrEMBL
    A0A087WT15
    Related
    ENSP00000477513.1, ENST00000482742.5
    Conserved Domains (1) summary
    COG0008
    Location:7 → 24
    GlnS; Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]

  10. NM_001257240.3 → NP_001244169.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform 7

    See identical proteins and their annotated locations for NP_001244169.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) has multiple differences, compared to variant 1, including the use of a downstream, in-frame start codon and alternate 3' UTR. Variants 9, 11 and 12 encode the same isoform (7) which is significantly shorter and has a unique C-terminus, compared to isoform 1.
    Source sequence(s)
    AL096764, DB292609, DN992019
    Consensus CDS
    CCDS76013.1
    UniProtKB/TrEMBL
    A0A087WT15
    Conserved Domains (1) summary
    COG0008
    Location:7 → 24
    GlnS; Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]

  11. NM_001257241.3 → NP_001244170.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform 8

    See identical proteins and their annotated locations for NP_001244170.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13) has multiple differences, compared to variant 1, including the use of an alternate start codon and alternate 3' UTR. The encoded isoform (8) is shorter and has distinct N- and C-termini, compared to isoform 1.
    Source sequence(s)
    AK302890, AL096764, BF239206, DB292609
    UniProtKB/Swiss-Prot
    Q9NP73
    Conserved Domains (1) summary
    cl10013
    Location:4 → 42
    Glycosyltransferase_GTB-type; glycosyltransferase family 1 and related proteins with GTB topology

  12. NM_001324290.2 → NP_001311219.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AL096764
    UniProtKB/TrEMBL
    A0A096LP10
    Related
    ENSP00000485333.1, ENST00000623255.1

  13. NM_001324291.2 → NP_001311220.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL096764
    Consensus CDS
    CCDS76013.1
    UniProtKB/TrEMBL
    A0A087WT15

  14. NM_001324292.2 → NP_001311221.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AL049563, AL096764
    UniProtKB/TrEMBL
    A0A096LPI3
    Conserved Domains (3) summary
    cd04508
    Location:496 → 544
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    cl10013
    Location:4 → 120
    Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...
    cl19932
    Location:239 → 345
    OTU; OTU-like cysteine protease

  15. NM_001324293.1 → NP_001311222.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AL049563, AL096764
    UniProtKB/TrEMBL
    A0A096LPI3
    Related
    ENSP00000485624.2, ENST00000623622.2

  16. NM_001324294.2 → NP_001311223.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL096764
    Consensus CDS
    CCDS76013.1
    UniProtKB/TrEMBL
    A0A087WT15
    Related
    ENSP00000485392.1, ENST00000623189.1

  17. NM_018466.6 → NP_060936.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform 2

    See identical proteins and their annotated locations for NP_060936.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks a large portion of the 3' coding region and uses an alternate 3' terminal exon, compared to variant 1. The resulting isoform (2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK056347, AL096764, BC005336, BF699152
    Consensus CDS
    CCDS14559.1
    UniProtKB/TrEMBL
    A0A096LP10
    Related
    ENSP00000361047.3, ENST00000371979.7
    Conserved Domains (1) summary
    cl10013
    Location:4 → 120
    Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...

RNA

  1. NR_033125.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) has multiple differences, compared to variant 1. This variant is represented as non-coding because use of the downstream start codon used in variant 5 results in a short ORF that does not meet RefSeq criteria.
    Source sequence(s)
    AK056347, AL096764, AL524204, BC005336, BE747995, BF699152

  2. NR_136735.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) has multiple differences, compared to variant 1. This variant is represented as non-coding because use of the downstream start codon used in variant 5 results in a short ORF that does not meet RefSeq criteria.
    Source sequence(s)
    AL096764

  3. NR_148693.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL049563, AL096764
    Related
    ENST00000636363.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    111681170..111760649
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531031.2 → XP_011529333.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform X9

    See identical proteins and their annotated locations for XP_011529333.1

    UniProtKB/TrEMBL
    A0A096LPI3
    Conserved Domains (2) summary
    cd20447
    Location:384 → 463
    Tudor_TDRD13; Tudor domain found in Tudor domain-containing protein 13 (TDRD13)
    cl19932
    Location:135 → 241
    OTU; OTU-like cysteine protease

  2. XM_006724698.4 → XP_006724761.2  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform X9

    See identical proteins and their annotated locations for XP_006724761.2

    UniProtKB/TrEMBL
    A0A096LPI3
    Conserved Domains (2) summary
    cd20447
    Location:384 → 463
    Tudor_TDRD13; Tudor domain found in Tudor domain-containing protein 13 (TDRD13)
    cl19932
    Location:135 → 241
    OTU; OTU-like cysteine protease

  3. XM_011531028.3 → XP_011529330.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform X1

    UniProtKB/TrEMBL
    A0A096LPI3
    Conserved Domains (3) summary
    cd04508
    Location:496 → 544
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    cl10013
    Location:4 → 120
    Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...
    cl19932
    Location:239 → 345
    OTU; OTU-like cysteine protease

  4. XM_011531030.3 → XP_011529332.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform X7

    UniProtKB/TrEMBL
    A0A096LPI3
    Conserved Domains (3) summary
    cd04508
    Location:496 → 544
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    cl10013
    Location:4 → 120
    Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...
    cl19932
    Location:239 → 345
    OTU; OTU-like cysteine protease

  5. XM_017029847.2 → XP_016885336.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform X3

    UniProtKB/TrEMBL
    A0A096LPI3

  6. XM_006724693.4 → XP_006724756.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform X5

    UniProtKB/TrEMBL
    A0A096LPI3
    Conserved Domains (3) summary
    cd04508
    Location:496 → 544
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    cl10013
    Location:4 → 120
    Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...
    cl19932
    Location:239 → 345
    OTU; OTU-like cysteine protease

  7. XM_047442523.1 → XP_047298479.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform X11

  8. XM_017029846.2 → XP_016885335.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform X2

    UniProtKB/TrEMBL
    A0A096LPI3

  9. XM_047442520.1 → XP_047298476.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform X4

  10. XM_017029848.2 → XP_016885337.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform X10

    UniProtKB/TrEMBL
    A0A096LPI3

  11. XM_047442521.1 → XP_047298477.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform X6

  12. XM_047442522.1 → XP_047298478.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform X8

  13. XM_047442525.1 → XP_047298481.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform X13

  14. XM_006724697.4 → XP_006724760.2  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform X9

    See identical proteins and their annotated locations for XP_006724760.2

    UniProtKB/TrEMBL
    A0A096LPI3
    Conserved Domains (2) summary
    cd20447
    Location:384 → 463
    Tudor_TDRD13; Tudor domain found in Tudor domain-containing protein 13 (TDRD13)
    cl19932
    Location:135 → 241
    OTU; OTU-like cysteine protease

  15. XM_017029850.3 → XP_016885339.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform X16

    UniProtKB/TrEMBL
    A0A096LPI3

  16. XM_017029849.2 → XP_016885338.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform X15

    UniProtKB/TrEMBL
    A0A096LPI3

  17. XM_024452449.2 → XP_024308217.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform X17

    UniProtKB/TrEMBL
    A0A096LPI3
    Conserved Domains (3) summary
    cd04508
    Location:496 → 544
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    cl10013
    Location:4 → 120
    Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...
    cl19932
    Location:239 → 345
    OTU; OTU-like cysteine protease

  18. XM_011531033.4 → XP_011529335.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform X9

    See identical proteins and their annotated locations for XP_011529335.1

    UniProtKB/TrEMBL
    A0A096LPI3
    Conserved Domains (2) summary
    cd20447
    Location:384 → 463
    Tudor_TDRD13; Tudor domain found in Tudor domain-containing protein 13 (TDRD13)
    cl19932
    Location:135 → 241
    OTU; OTU-like cysteine protease

  19. XM_011531032.2 → XP_011529334.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform X9

    See identical proteins and their annotated locations for XP_011529334.1

    UniProtKB/TrEMBL
    A0A096LPI3
    Conserved Domains (2) summary
    cd20447
    Location:384 → 463
    Tudor_TDRD13; Tudor domain found in Tudor domain-containing protein 13 (TDRD13)
    cl19932
    Location:135 → 241
    OTU; OTU-like cysteine protease

  20. XM_047442524.1 → XP_047298480.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform X12

  21. XM_011531034.3 → XP_011529336.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform X14

    Conserved Domains (2) summary
    cd04508
    Location:293 → 341
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    cl19932
    Location:36 → 142
    OTU; OTU-like cysteine protease

  22. XM_047442526.1 → XP_047298482.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform X18

  23. XM_047442528.1 → XP_047298484.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform X21

  24. XM_047442529.1 → XP_047298485.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform X22

  25. XM_047442527.1 → XP_047298483.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform X20

  26. XM_017029852.2 → XP_016885341.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform X19

  27. XM_047442531.1 → XP_047298487.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform X24

  28. XM_047442530.1 → XP_047298486.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform X23

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    110129414..110208990
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054327894.1 → XP_054183869.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform X9

  2. XM_054327888.1 → XP_054183863.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform X9

  3. XM_054327878.1 → XP_054183853.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform X1

  4. XM_054327884.1 → XP_054183859.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform X7

  5. XM_054327880.1 → XP_054183855.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform X3

  6. XM_054327882.1 → XP_054183857.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform X5

  7. XM_054327891.1 → XP_054183866.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform X11

  8. XM_054327879.1 → XP_054183854.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform X2

  9. XM_054327881.1 → XP_054183856.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform X4

  10. XM_054327890.1 → XP_054183865.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform X10

  11. XM_054327883.1 → XP_054183858.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform X6

  12. XM_054327885.1 → XP_054183860.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform X8

  13. XM_054327893.1 → XP_054183868.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform X13

  14. XM_054327889.1 → XP_054183864.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform X9

  15. XM_054327897.1 → XP_054183872.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform X16

  16. XM_054327896.1 → XP_054183871.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform X15

  17. XM_054327898.1 → XP_054183873.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform X17

  18. XM_054327886.1 → XP_054183861.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform X9

  19. XM_054327887.1 → XP_054183862.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform X9

  20. XM_054327892.1 → XP_054183867.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform X12

  21. XM_054327895.1 → XP_054183870.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform X14

  22. XM_054327899.1 → XP_054183874.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform X18

  23. XM_054327902.1 → XP_054183877.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform X21

  24. XM_054327903.1 → XP_054183878.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform X22

  25. XM_054327901.1 → XP_054183876.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform X20

  26. XM_054327900.1 → XP_054183875.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform X19

  27. XM_054327905.1 → XP_054183880.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform X24

  28. XM_054327904.1 → XP_054183879.1  putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform X23

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_024810.1: Suppressed sequence

    Description
    NM_024810.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NP73.2 GenPept UniProtKB/Swiss-Prot:Q9NP73

Gene LinkOut

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