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PSCA prostate stem cell antigen [ Homo sapiens (human) ]

Gene ID: 8000, updated on 5-Mar-2024

Summary

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Official Symbol
PSCAprovided by HGNC
Official Full Name
prostate stem cell antigenprovided by HGNC
Primary source
HGNC:HGNC:9500
See related
Ensembl:ENSG00000167653 MIM:602470; AllianceGenome:HGNC:9500
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PRO232; lncPSCA
Summary
This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas. This gene includes a polymorphism that results in an upstream start codon in some individuals; this polymorphism is thought to be associated with a risk for certain gastric and bladder cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
Expression
Biased expression in stomach (RPKM 721.2), urinary bladder (RPKM 108.9) and 1 other tissue See more
Orthologs
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Genomic context

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See PSCA in Genome Data Viewer
Location:
8q24.3
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (142670297..142682725)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (143813825..143826193)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (143751715..143764143)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928087 Neighboring gene Jrk helix-turn-helix protein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143743050-143743570 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143743571-143744089 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143748299-143749154 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19602 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28065 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19603 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:143762658-143763304 Neighboring gene uncharacterized LOC124902032 Neighboring gene lncRNA associated with ovarian cancer 1 Neighboring gene lymphocyte antigen 6 family member K

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The PSCA rs2294008 (C/T) Polymorphism Increases the Risk of Gastric and Bladder Cancer: A Meta-Analysis. Wang XF, et al. Genet Test Mol Biomarkers, 2023 Feb. PMID 36853840
  2. LncPSCA in the 8q24.3 risk locus drives gastric cancer through destabilizing DDX5. Zheng Y, et al. EMBO Rep, 2021 Nov 4. PMID 34472665, Free PMC Article
  3. Silencing of the proteasome and oxidative stress impair endoplasmic reticulum targeting and signal cleavage of a prostate carcinoma antigen. Hoefer F, et al. Biochem Biophys Res Commun, 2021 May 21. PMID 33774280
  4. The Correlation between PSCA Expression and Neuroendocrine Differentiation in Prostate Cancer. Xiang Q, et al. Biomed Res Int, 2020. PMID 33029516, Free PMC Article
  5. Evolutionary History of the Risk of SNPs for Diffuse-Type Gastric Cancer in the Japanese Population. Iwasaki RL, et al. Genes (Basel), 2020 Jul 10. PMID 32664326, Free PMC Article

See all (142) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The PSCA rs2294008 (C/T) Polymorphism Increases the Risk of Gastric and Bladder Cancer: A Meta-Analysis.
    Title: The PSCA rs2294008 (C/T) Polymorphism Increases the Risk of Gastric and Bladder Cancer: A Meta-Analysis.
  2. Diagnostic Efficacy of PSMA and PSCA mRNAs Combined to PSA in Prostate Cancer Patients.
    Title: Diagnostic Efficacy of PSMA and PSCA mRNAs Combined to PSA in Prostate Cancer Patients.
  3. LncPSCA in the 8q24.3 risk locus drives gastric cancer through destabilizing DDX5.
    Title: LncPSCA in the 8q24.3 risk locus drives gastric cancer through destabilizing DDX5.
  4. Silencing of the proteasome and oxidative stress impair endoplasmic reticulum targeting and signal cleavage of a prostate carcinoma antigen.
    Title: Silencing of the proteasome and oxidative stress impair endoplasmic reticulum targeting and signal cleavage of a prostate carcinoma antigen.
  5. Polymorphisms PSCA rs2294008, IL-4 rs2243250 and MUC1 rs4072037 are associated with gastric cancer in a high risk population.
    Title: Polymorphisms PSCA rs2294008, IL-4 rs2243250 and MUC1 rs4072037 are associated with gastric cancer in a high risk population.
  6. Impact of PSCA Polymorphisms on the Risk of Duodenal Ulcer.
    Title: Impact of PSCA Polymorphisms on the Risk of Duodenal Ulcer.
  7. The Correlation between PSCA Expression and Neuroendocrine Differentiation in Prostate Cancer.
    Title: The Correlation between PSCA Expression and Neuroendocrine Differentiation in Prostate Cancer.
  8. Evolutionary History of the Risk of SNPs for Diffuse-Type Gastric Cancer in the Japanese Population.
    Title: Evolutionary History of the Risk of SNPs for Diffuse-Type Gastric Cancer in the Japanese Population.
  9. Risk of gastric ulcer contributed by genetic polymorphisms of PSCA: A case-control study based on Chinese Han population.
    Title: Risk of gastric ulcer contributed by genetic polymorphisms of PSCA: A case-control study based on Chinese Han population.
  10. Association of MUC1 5640G>A and PSCA 5057C>T polymorphisms with the risk of gastric cancer in Northern Iran.
    Title: Association of MUC1 5640G>A and PSCA 5057C>T polymorphisms with the risk of gastric cancer in Northern Iran.
Submit: New GeneRIF Correction See all GeneRIFs (112)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study identifies two susceptibility loci for duodenal ulcer in the Japanese population.
EBI GWAS Catalog
A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.
EBI GWAS Catalog
Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer.
EBI GWAS Catalog
Genome-wide association study identifies multiple loci associated with bladder cancer risk.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables acetylcholine receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of neurotransmitter receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
prostate stem cell antigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011722.3 RefSeqGene

    Range
    15188..17418
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005672.5 → NP_005663.2  prostate stem cell antigen preproprotein

    See identical proteins and their annotated locations for NP_005663.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript but encodes the functional protein.
    Source sequence(s)
    AI685668, BC048808, CB993163
    Consensus CDS
    CCDS47925.2
    UniProtKB/Swiss-Prot
    O43653, Q6UW92
    Related
    ENSP00000301258.4, ENST00000301258.5
    Conserved Domains (1) summary
    pfam00021
    Location:14 → 84
    UPAR_LY6; u-PAR/Ly-6 domain

RNA

  1. NR_033343.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in its 5'-most exon, compared to variant 1. This variant is represented as non-coding because it lacks an in-frame coding region, compared to variant 1.
    Source sequence(s)
    AC108002, AI685668, BC048808, BI758811, BU157227

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    142670297..142682725
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    143813825..143826193
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O43653.2 GenPept UniProtKB/Swiss-Prot:O43653

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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