TEDC2 tubulin epsilon and delta complex 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TEDC2provided by HGNC
Official Full Name: tubulin epsilon and delta complex 2provided by HGNC
Primary source: HGNC:HGNC:25849
See related: Ensembl:ENSG00000162062 AllianceGenome:HGNC:25849
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: C16orf59
Summary: Predicted to be involved in positive regulation of smoothened signaling pathway. Predicted to be located in centriole and cilium. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in testis (RPKM 2.6), bone marrow (RPKM 1.5) and 19 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 16p13.3

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (2460109..2464963)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (2482238..2487092)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (2510110..2514964)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A pan-cancer analysis of the prognostic implication and oncogenic role of tubulin epsilon and delta complex 2 (TEDC2) in human tumors.
Title: A pan-cancer analysis of the prognostic implication and oncogenic role of tubulin epsilon and delta complex 2 (TEDC2) in human tumors.
TEDC2 correlated with prognosis and immune microenvironment in lung adenocarcinoma.
Title: TEDC2 correlated with prognosis and immune microenvironment in lung adenocarcinoma.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-34827 (e-PCR)
- UniSTS:7154

RH98649 (e-PCR)
- UniSTS:84730

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of smoothened signaling pathway	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in centriole	ISS Inferred from Sequence or Structural Similarity more info
located_in cilium	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tubulin epsilon and delta complex protein 2

Names: uncharacterized protein C16orf59

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025108.3 → NP_079384.2 tubulin epsilon and delta complex protein 2

See identical proteins and their annotated locations for NP_079384.2

Status: VALIDATED

Source sequence(s)

AC106820, AL559561, BC018719

Consensus CDS

CCDS10468.2

UniProtKB/Swiss-Prot

B4DXD7, Q7L2K0, Q96H61, Q9H872

UniProtKB/TrEMBL

H3BND0

Related

ENSP00000355022.4, ENST00000361837.9

Conserved Domains (1) summary

pfam15764
Location:148 → 431

DUF4693; Domain of unknown function (DUF4693)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000016.10 Reference GRCh38.p14 Primary Assembly

Range

2460109..2464963

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011522667.2 → XP_011520969.1 tubulin epsilon and delta complex protein 2 isoform X1

UniProtKB/TrEMBL

H3BND0

Conserved Domains (1) summary

pfam15764
Location:115 → 398

DUF4693; Domain of unknown function (DUF4693)