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PF3D7_1132800 aquaglyceroporin [ Plasmodium falciparum 3D7 ]

Gene ID: 810885, updated on 16-Oct-2023

Summary

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Gene symbol
PF3D7_1132800
Gene description
aquaglyceroporin
Locus tag
PF3D7_1132800
Gene type
protein coding
RNA name
aquaglyceroporin
RefSeq status
PROVISIONAL
Organism
Plasmodium falciparum 3D7 (isolate: 3D7)
Lineage
Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
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Genomic context

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Location:
chromosome: 11
Exon count:
1
Sequence:
Chromosome: 11; NC_037282.1 (1271204..1271980)

Chromosome 11 - NC_037282.1Genomic Context describing neighboring genes Neighboring gene pre-mRNA-splicing factor 38A, putative Neighboring gene 50S ribosomal protein L2, putative Neighboring gene glycine cleavage system H protein Neighboring gene conserved Plasmodium protein, unknown function

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037282.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Aquaglyceroporin PbAQP is required for efficient progression through the liver stage of Plasmodium infection. Promeneur D, et al. Sci Rep, 2018 Jan 12. PMID 29330527, Free PMC Article
  2. Molar concentrations of sorbitol and polyethylene glycol inhibit the Plasmodium aquaglyceroporin but not that of E. coli: involvement of the channel vestibules. Song J, et al. Biochim Biophys Acta, 2012 May. PMID 22326891
  3. Crystal structure of the aquaglyceroporin PfAQP from the malarial parasite Plasmodium falciparum. Newby ZE, et al. Nat Struct Mol Biol, 2008 Jun. PMID 18500352, Free PMC Article
  4. Aquaglyceroporin PbAQP during intraerythrocytic development of the malaria parasite Plasmodium berghei. Promeneur D, et al. Proc Natl Acad Sci U S A, 2007 Feb 13. PMID 17284593, Free PMC Article
  5. A single, bi-functional aquaglyceroporin in blood-stage Plasmodium falciparum malaria parasites. Hansen M, et al. J Biol Chem, 2002 Feb 15. PMID 11729204

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PfAQP has high and EcGlpF low water permeability, and explain the inhibiting effect of sorbitol on PfAQP by its binding to the extracellular vestibule.
    Title: Molar concentrations of sorbitol and polyethylene glycol inhibit the Plasmodium aquaglyceroporin but not that of E. coli: involvement of the channel vestibules.
  2. 2.05-A resolution structure provides key evidence for the basis of water versus glycerol selectivity
    Title: Crystal structure of the aquaglyceroporin PfAQP from the malarial parasite Plasmodium falciparum.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by GeneDB

Function Evidence Code Pubs
enables ammonium transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within glucosylglycerol transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within glycolipid biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within polyol transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within water transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in Maurer's cleft RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
located_in cell surface HDA PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
aquaglyceroporin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_037282.1 Reference assembly

    Range
    1271204..1271980
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001347973.3 → XP_001348009.1  aquaglyceroporin [Plasmodium falciparum 3D7]

    See identical proteins and their annotated locations for XP_001348009.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A024UYN0, A0A024VW93, A0A024WN19, A0A024X7A3, A0A0L0D088, A0A0L1I716, A0A0L7KKB6, A0A0L7LWK6, Q8II36, Q8WPZ6, W4IGD2, W4ISF9, W7FDG2, W7JLP7, W7K5E1
    Conserved Domains (1) summary
    PTZ00016
    Location:1 → 247
    PTZ00016; aquaglyceroporin; Provisional
Nucleotide Protein
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