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PF3D7_1147500 protein farnesyltransferase subunit beta [ Plasmodium falciparum 3D7 ]

Gene ID: 811026, updated on 16-Oct-2023

Summary

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Gene symbol
PF3D7_1147500
Gene description
protein farnesyltransferase subunit beta
Locus tag
PF3D7_1147500
Gene type
protein coding
RNA name
protein farnesyltransferase subunit beta
RefSeq status
PROVISIONAL
Organism
Plasmodium falciparum 3D7 (isolate: 3D7)
Lineage
Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
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Genomic context

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Location:
chromosome: 11
Exon count:
1
Sequence:
Chromosome: 11; NC_037282.1 (1889826..1892597, complement)

Chromosome 11 - NC_037282.1Genomic Context describing neighboring genes Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene ATP synthase subunit delta, mitochondrial, putative

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037282.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Resistance to a protein farnesyltransferase inhibitor in Plasmodium falciparum. Eastman RT, et al. J Biol Chem, 2005 Apr 8. PMID 15661734
  2. Protein farnesyltransferase and protein prenylation in Plasmodium falciparum. Chakrabarti D, et al. J Biol Chem, 2002 Nov 1. PMID 12194969
  3. Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics. Cowell AN, et al. Science, 2018 Jan 12. PMID 29326268, Free PMC Article
  4. Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, et al. Nature, 2002 Oct 3. PMID 12368864, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by GeneDB

Function Evidence Code Pubs
enables protein farnesyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within protein farnesylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of protein farnesyltransferase complex ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
protein farnesyltransferase subunit beta
XP_001348150.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_037282.1 Reference assembly

    Range
    1889826..1892597 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001348114.2 → XP_001348150.2  protein farnesyltransferase subunit beta [Plasmodium falciparum 3D7]

    See identical proteins and their annotated locations for XP_001348150.2

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A024WIP2, Q5EI74, Q8IHP6, W7JRW6
    Conserved Domains (1) summary
    cd02893
    Location:425 → 848
    FTase; Protein farnesyltransferase (FTase)_like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). FTases are a subgroup of PTase family of lipid-modifying enzymes. PTases catalyze the ...
Nucleotide Protein
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