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PF3D7_1215000 thioredoxin peroxidase 2 [ Plasmodium falciparum 3D7 ]

Gene ID: 811198, updated on 16-Oct-2023

Summary

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Gene symbol
PF3D7_1215000
Gene description
thioredoxin peroxidase 2
Locus tag
PF3D7_1215000
Gene type
protein coding
RNA name
thioredoxin peroxidase 2
RefSeq status
PROVISIONAL
Organism
Plasmodium falciparum 3D7 (isolate: 3D7)
Lineage
Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
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Genomic context

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Location:
chromosome: 12
Exon count:
1
Sequence:
Chromosome: 12; NC_037284.1 (621125..621775)

Chromosome 12 - NC_037284.1Genomic Context describing neighboring genes Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene conserved protein, unknown function Neighboring gene SUN domain-containing protein, putative Neighboring gene peptidyl-prolyl cis-trans isomerase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037284.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The P. falciparum mitochondrial peroxiredoxin is dependent on peroxidase with a preference for H2O2, and it has an important function in detoxification of reactive oxygen in the parasite's mitochondrion.
    Title: Structural and biochemical characterization of a mitochondrial peroxiredoxin from Plasmodium falciparum.
  2. thioredoxin-2 from Plasmodium falciparum is a constituent of an essential parasitic protein export complex; analysis of its structure
    Title: Crystal structure and solution characterization of the thioredoxin-2 from Plasmodium falciparum, a constituent of an essential parasitic protein export complex.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by GeneDB

Function Evidence Code Pubs
enables thioredoxin peroxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within response to oxidative stress IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 

General protein information

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Preferred Names
thioredoxin peroxidase 2
XP_001350554.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_037284.1 Reference assembly

    Range
    621125..621775
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001350518.1 → XP_001350554.1  thioredoxin peroxidase 2 [Plasmodium falciparum 3D7]

    See identical proteins and their annotated locations for XP_001350554.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A024V432, A0A024VPJ6, A0A024W3L0, A0A024WM29, A0A024X4N3, A0A0L1I5X7, A0A0L7KI26, A0A0L7M7S5, Q8I5Q6, Q9BKL4, W4IFH4, W4J3I4, W7EZ14, W7FRQ1, W7JRH9
    Conserved Domains (1) summary
    cd03015
    Location:22 → 194
    PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...
Nucleotide Protein
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Molecular Biology Databases
Research Materials