U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PF3D7_1462800 glyceraldehyde-3-phosphate dehydrogenase [ Plasmodium falciparum 3D7 ]

Gene ID: 812180, updated on 17-May-2024

Summary

Go to the top of the page Help
Gene symbol
PF3D7_1462800
Gene description
glyceraldehyde-3-phosphate dehydrogenase
Primary source
PlasmoDB:PF3D7_1462800
Locus tag
PF3D7_1462800
Gene type
protein coding
RNA name
glyceraldehyde-3-phosphate dehydrogenase
RefSeq status
PROVISIONAL
Organism
Plasmodium falciparum 3D7 (isolate: 3D7)
Lineage
Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 14
Exon count:
2
Sequence:
Chromosome: 14; NC_037283.1 (2559098..2560347)

Chromosome 14 - NC_037283.1Genomic Context describing neighboring genes Neighboring gene conserved Plasmodium membrane protein, unknown function Neighboring gene cytochrome c1 precursor, putative Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene mediator of RNA polymerase II transcription subunit 20, putative

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_037283.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Discovery of covalent inhibitors of glyceraldehyde-3-phosphate dehydrogenase, a target for the treatment of malaria. Bruno S, et al. J Med Chem, 2014 Sep 11. PMID 25137375
  2. Crystal structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum at 2.25 A resolution reveals intriguing extra electron density in the active site. Robien MA, et al. Proteins, 2006 Mar 15. PMID 16345073
  3. Structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum. Satchell JF, et al. Acta Crystallogr D Biol Crystallogr, 2005 Sep. PMID 16131754
  4. The N'-terminal domain of glyceraldehyde-3-phosphate dehydrogenase of the apicomplexan Plasmodium falciparum mediates GTPase Rab2-dependent recruitment to membranes. Daubenberger CA, et al. Biol Chem, 2003 Aug. PMID 12974391
  5. Identification and recombinant expression of glyceraldehyde-3-phosphate dehydrogenase of Plasmodium falciparum. Daubenberger CA, et al. Gene, 2000 Apr 4. PMID 10767547

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate that the 3-bromo-isoxazoline derivatives showed a time- and concentration-dependent inactivatioof glyceraldehyde-3-phosphate dehydrogenase (GAPDH), with a large variability in reaction rates
    Title: Discovery of covalent inhibitors of glyceraldehyde-3-phosphate dehydrogenase, a target for the treatment of malaria.
  2. The major structural feature distinguishing human GAPDH from PfGAPDH is the insertion of a dipeptide (-KG-) in the so-called S loop, which alters the chemical environment of the groove that encompasses the R dyad and links adjacent cofactor-binding sites
    Title: Structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum.
  3. In all four subunits a completely unexpected large island of extra electron density in the active site is observed.
    Title: Crystal structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum at 2.25 A resolution reveals intriguing extra electron density in the active site.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by GeneDB

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within gluconeogenesis TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within glycolytic process TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within symbiont entry into host ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular vesicle HDA PubMed 
located_in food vacuole HDA PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 

General protein information

Go to the top of the page Help
Preferred Names
glyceraldehyde-3-phosphate dehydrogenase
XP_001348772.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_037283.1 Reference assembly

    Range
    2559098..2560347
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001348736.3 → XP_001348772.1  glyceraldehyde-3-phosphate dehydrogenase [Plasmodium falciparum 3D7]

    See identical proteins and their annotated locations for XP_001348772.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A024V013, A0A024VYW4, A0A024WHA8, A0A024X0L3, A0A0L1IBY1, A0A0L7KDR6, A0A2I0C1J8, Q8IKK7, Q8T6B1, W4I9B4, W7F419, W7FMT1, W7J3S3
    Conserved Domains (1) summary
    PTZ00023
    Location:2 → 337
    PTZ00023; glyceraldehyde-3-phosphate dehydrogenase; Provisional
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Miscellaneous