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PF3D7_1324800 dihydrofolate synthase/folylpolyglutamate synthase [ Plasmodium falciparum 3D7 ]

Gene ID: 814111, updated on 16-Oct-2023

Summary

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Gene symbol
PF3D7_1324800
Gene description
dihydrofolate synthase/folylpolyglutamate synthase
Locus tag
PF3D7_1324800
Gene type
protein coding
RNA name
dihydrofolate synthase/folylpolyglutamate synthase
RefSeq status
PROVISIONAL
Organism
Plasmodium falciparum 3D7 (isolate: 3D7)
Lineage
Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
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Genomic context

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Location:
chromosome: 13
Exon count:
4
Sequence:
Chromosome: 13; NC_004331.3 (1036543..1038531, complement)

Chromosome 13 - NC_004331.3Genomic Context describing neighboring genes Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene SNARE protein, putative Neighboring gene L-lactate dehydrogenase Neighboring gene U6 snRNA-associated Sm-like protein LSm6, putative

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_004331.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A bifunctional dihydrofolate synthetase--folylpolyglutamate synthetase in Plasmodium falciparum identified by functional complementation in yeast and bacteria. Salcedo E, et al. Mol Biochem Parasitol, 2001 Feb. PMID 11223131
  2. A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, et al. Nature, 2005 Nov 3. PMID 16267556

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GeneDB

Function Evidence Code Pubs
enables ATP binding TAS
Traceable Author Statement
more info
 PubMed 
enables dihydrofolate synthase activity TAS
Traceable Author Statement
more info
 PubMed 
enables tetrahydrofolylpolyglutamate synthase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within folic acid-containing compound biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 

General protein information

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Preferred Names
dihydrofolate synthase/folylpolyglutamate synthase
XP_001349988.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004331.3 Reference assembly

    Range
    1036543..1038531 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001349952.1 → XP_001349988.1  dihydrofolate synthase/folylpolyglutamate synthase [Plasmodium falciparum 3D7]

    See identical proteins and their annotated locations for XP_001349988.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A024V1W6, A0A024X4C6, A0A0L1IDH9, Q8IE69, Q9U738, W4IBG9, W4IZ23, W7F302, W7FDW1, W7JIV1, W7JPW2
    Conserved Domains (1) summary
    COG0285
    Location:56 → 423
    FolC; Folylpolyglutamate synthase/Dihydropteroate synthase [Coenzyme transport and metabolism]
Nucleotide Protein
Heading Accession and Version

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Molecular Biology Databases