PF3D7_1347200 nucleoside transporter 1 [Plasmodium falciparum 3D7] - Gene

Summary

Gene symbol: PF3D7_1347200
Gene description: nucleoside transporter 1
Locus tag: PF3D7_1347200
Gene type: protein coding
RNA name: nucleoside transporter 1
RefSeq status: PROVISIONAL
Organism: Plasmodium falciparum 3D7 (isolate: 3D7)
Lineage: Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
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See PF3D7_1347200 in Genome Data Viewer

Chromosome 13 - NC_004331.3 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

results may help identify the binding site(s) of PfENT1 inhibitors
Title: Accessibility of substituted cysteines in TM2 and TM10 transmembrane segments in the Plasmodium falciparum equilibrative nucleoside transporter PfENT1.
ENT1 mediated transport of natural purine substrates.
Title: Transport of purines and purine salvage pathway inhibitors by the Plasmodium falciparum equilibrative nucleoside transporter PfENT1.
Taken together these results demonstrate that, in addition to hypoxanthine, inosine and adenosine, PfNT1 is essential for the transport and utilization of xanthine, guanine and guanosine.
Title: Genetic evidence for the essential role of PfNT1 in the transport and utilization of xanthine, guanine, guanosine and adenine by Plasmodium falciparum.
Data report that transgenic parasites lacking NT1 (nucleoside transporter 1) are auxotrophic for hypoxanthine, inosine, and adenosine under physiological conditions and are viable only if these nutrients are provided at excess concentrations.
Title: The plasma membrane permease PfNT1 is essential for purine salvage in the human malaria parasite Plasmodium falciparum.
Serveing as a major route for the uptake of nucleosides across the parasite plasma membrane.
Title: Transport of nucleosides across the Plasmodium falciparum parasite plasma membrane has characteristics of PfENT1.

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Function	Evidence Code	Pubs
enables nucleoside transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables purine nucleoside transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within purine nucleoside transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to xenobiotic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Maurer's cleft	RCA inferred from Reviewed Computational Analysis more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed