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PF3D7_1354500 adenylosuccinate synthetase [ Plasmodium falciparum 3D7 ]

Gene ID: 814251, updated on 17-May-2024

Summary

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Gene symbol
PF3D7_1354500
Gene description
adenylosuccinate synthetase
Primary source
PlasmoDB:PF3D7_1354500
Locus tag
PF3D7_1354500
Gene type
protein coding
RNA name
adenylosuccinate synthetase
RefSeq status
PROVISIONAL
Organism
Plasmodium falciparum 3D7 (isolate: 3D7)
Lineage
Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
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Genomic context

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Location:
chromosome: 13
Exon count:
2
Sequence:
Chromosome: 13; NC_004331.3 (2174346..2175797)

Chromosome 13 - NC_004331.3Genomic Context describing neighboring genes Neighboring gene large subunit rRNA methyltransferase, putative Neighboring gene V-type proton ATPase 21 kDa proteolipid subunit, putative Neighboring gene 60S ribosomal protein L7-2, putative Neighboring gene conserved Plasmodium protein, unknown function

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_004331.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mutational analysis of cysteine 328 and cysteine 368 at the interface of Plasmodium falciparum adenylosuccinate synthetase. Mehrotra S, et al. Biochim Biophys Acta, 2012 Apr. PMID 22289630
  2. Unique kinetic mechanism of Plasmodium falciparum adenylosuccinate synthetase. Raman J, et al. Mol Biochem Parasitol, 2004 Nov. PMID 15500910
  3. Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, et al. Nature, 2002 Oct 3. PMID 12368867
  4. Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, et al. Nature, 2002 Oct 3. PMID 12368864, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cysteines at the dimer interface of Plasmodium falciparum adenylosuccinate synthetase may be charged and exist as thiolate anion.
    Title: Mutational analysis of cysteine 328 and cysteine 368 at the interface of Plasmodium falciparum adenylosuccinate synthetase.
  2. kinetic evidence shows that unlike all other AdSS, Plasmodium falciparum AdSS (PfAdSS) has ordered substrate binding
    Title: Unique kinetic mechanism of Plasmodium falciparum adenylosuccinate synthetase.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by GeneDB

Function Evidence Code Pubs
enables GTP binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables adenylosuccinate synthase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within AMP biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within purine nucleotide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
adenylosuccinate synthetase
XP_001350257.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004331.3 Reference assembly

    Range
    2174346..2175797
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001350221.1 → XP_001350257.1  adenylosuccinate synthetase [Plasmodium falciparum 3D7]

    See identical proteins and their annotated locations for XP_001350257.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q8IDF6, Q9U8D3
    UniProtKB/TrEMBL
    A0A024VJ47, A0A024W310, A0A024WK07, A0A024X2L5, A0A0L1IFB7, A0A0L7KI77, W4IC42, W4J076, W7FRN5, W7JNK7, W7JS70
    Conserved Domains (1) summary
    PTZ00350
    Location:3 → 437
    PTZ00350; adenylosuccinate synthetase; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IDF6.1

Gene LinkOut

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