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PF3D7_0306300 glutaredoxin 1 [ Plasmodium falciparum 3D7 ]

Gene ID: 814381, updated on 16-Oct-2023

Summary

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Gene symbol
PF3D7_0306300
Gene description
glutaredoxin 1
Locus tag
PF3D7_0306300
Gene type
protein coding
RNA name
glutaredoxin 1
RefSeq status
PROVISIONAL
Organism
Plasmodium falciparum 3D7 (isolate: 3D7)
Lineage
Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
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Genomic context

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Location:
chromosome: 3
Exon count:
5
Sequence:
Chromosome: 3; NC_000521.4 (295107..296094, complement)

Chromosome 3 - NC_000521.4Genomic Context describing neighboring genes Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene activator of Hsp90 ATPase Neighboring gene FAD-dependent glycerol-3-phosphate dehydrogenase, putative Neighboring gene cytochrome c oxidase subunit ApiCOX35, putative

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000521.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Atomic resolution crystal structure of glutaredoxin 1 from Plasmodium falciparum and comparison with other glutaredoxins. Yogavel M, et al. Acta Crystallogr D Biol Crystallogr, 2014 Jan. PMID 24419382
  2. Conformational stability and energetics of Plasmodium falciparum glutaredoxin. Tripathi T, et al. Biochimie, 2010 Mar. PMID 20006670
  3. Plasmodium falciparum possesses a classical glutaredoxin and a second, glutaredoxin-like protein with a PICOT homology domain. Rahlfs S, et al. J Biol Chem, 2001 Oct 5. PMID 11479312
  4. The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Bowman S, et al. Nature, 1999 Aug 5. PMID 10448855
  5. Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, et al. Nature, 2002 Oct 3. PMID 12368867

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The crystal structure of Grx1 has been determined by the sulfur single-wavelength anomalous diffraction (S-SAD) method utilizing intrinsic protein and solvent S atoms.
    Title: Atomic resolution crystal structure of glutaredoxin 1 from Plasmodium falciparum and comparison with other glutaredoxins.
  2. Results describe the unfolding energetics and conformational stability of Plasmodium falciparum glutaredoxin.
    Title: Conformational stability and energetics of Plasmodium falciparum glutaredoxin.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by GeneDB

Function Evidence Code Pubs
enables antioxidant activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-disulfide reductase (glutathione) activity IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
glutaredoxin 1
XP_001351139.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000521.4 Reference assembly

    Range
    295107..296094 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001351103.1 → XP_001351139.1  glutaredoxin 1 [Plasmodium falciparum 3D7]

    See identical proteins and their annotated locations for XP_001351139.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A024VD23, A0A0L1IH35, A0A0L7K8U1, A0A2I0BTG5, Q7KXR4, Q9NLB2, W7FQ10
    Conserved Domains (1) summary
    cd03419
    Location:21 → 102
    GRX_GRXh_1_2_like; Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
4HJM_A.1
4MZB_A.1
4MZC_A.1
4N0Z_A.1
4N10_A.1
4N11_A.1

Gene LinkOut

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Research Materials
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