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PF3D7_0316600 formate-nitrite transporter [ Plasmodium falciparum 3D7 ]

Gene ID: 814480, updated on 23-Nov-2023

Summary

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Gene symbol
PF3D7_0316600
Gene description
formate-nitrite transporter
Locus tag
PF3D7_0316600
Gene type
protein coding
RNA name
formate-nitrite transporter
RefSeq status
PROVISIONAL
Organism
Plasmodium falciparum 3D7 (isolate: 3D7)
Lineage
Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
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Genomic context

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Location:
chromosome: 3
Exon count:
4
Sequence:
Chromosome: 3; NC_000521.4 (669302..670873, complement)

Chromosome 3 - NC_000521.4Genomic Context describing neighboring genes Neighboring gene conserved protein, unknown function Neighboring gene kinetochore protein NUF2, putative Neighboring gene protein YOP1, putative Neighboring gene 40S ribosomal protein S15A, putative

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000521.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Introduction of Scaffold Nitrogen Atoms Renders Inhibitors of the Malarial l-Lactate Transporter, PfFNT, Effective against the Gly107Ser Resistance Mutation. Walloch P, et al. J Med Chem, 2020 Sep 10. PMID 32816478
  2. The Malaria Parasite's Lactate Transporter PfFNT Is the Target of Antiplasmodial Compounds Identified in Whole Cell Phenotypic Screens. Hapuarachchi SV, et al. PLoS Pathog, 2017 Feb. PMID 28178359, Free PMC Article
  3. Substrate-analogous inhibitors exert antimalarial action by targeting the Plasmodium lactate transporter PfFNT at nanomolar scale. Golldack A, et al. PLoS Pathog, 2017 Feb. PMID 28178358, Free PMC Article
  4. A lactate and formate transporter in the intraerythrocytic malaria parasite, Plasmodium falciparum. Marchetti RV, et al. Nat Commun, 2015 Mar 31. PMID 25823844
  5. Identity of a Plasmodium lactate/H(+) symporter structurally unrelated to human transporters. Wu B, et al. Nat Commun, 2015 Feb 11. PMID 25669138

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A member of the microbial formate-nitrite transporter family, PfFNT, acts as a lactate/proton symporter in Plasmodium falciparum.
    Title: Identity of a Plasmodium lactate/H(+) symporter structurally unrelated to human transporters.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by GeneDB

Function Evidence Code Pubs
enables lactate:proton symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within acetate transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within formate transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within lactate transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within pyruvate transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface HDA PubMed 
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
formate-nitrite transporter

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000521.4 Reference assembly

    Range
    669302..670873 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001351200.1 → XP_001351236.1  formate-nitrite transporter [Plasmodium falciparum 3D7]

    See identical proteins and their annotated locations for XP_001351236.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A024VE45, A0A024WCQ5, A0A0L7K7N6, A0A2I0BTF8, O77389, W7G4M2
    Conserved Domains (1) summary
    pfam01226
    Location:27 → 279
    Form_Nir_trans; Formate/nitrite transporter
Nucleotide Protein
Heading Accession and Version

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