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Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase [ Rattus norvegicus (Norway rat) ]

Gene ID: 81522, updated on 13-Apr-2024

Summary

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Official Symbol
Mtrprovided by RGD
Official Full Name
5-methyltetrahydrofolate-homocysteine methyltransferaseprovided by RGD
Primary source
RGD:621283
See related
Ensembl:ENSRNOG00000017593 AllianceGenome:RGD:621283
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
methioninesynthase
Summary
Enables amino acid binding activity; folic acid binding activity; and methionine synthase activity. Involved in several processes, including alpha-amino acid metabolic process; cellular response to methionine; and cellular response to nitric oxide. Predicted to be active in cytosol. Biomarker of type 2 diabetes mellitus and vitamin B12 deficiency. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; autistic disorder; hematologic cancer (multiple); hyperhomocysteinemia; and methylmalonic aciduria and homocystinuria type cblG. Orthologous to human MTR (5-methyltetrahydrofolate-homocysteine methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 195.0), Adrenal (RPKM 138.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
17q12.1
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (62911705..62996544)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (58219998..58308560)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (66210444..66295014, complement)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene HEAT repeat containing 1 Neighboring gene transfer RNA serine (anticodon AGA) 47 Neighboring gene actinin alpha 2 Neighboring gene uncharacterized LOC120097915 Neighboring gene SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5-like Neighboring gene ribosomal protein S7, pseudogene 15 Neighboring gene small nucleolar RNA U3 Neighboring gene ryanodine receptor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Associations between genetic variants in folate and drug metabolizing pathways and relapse risk in pediatric acute lymphoid leukemia on CCG-1952. Vujkovic M, et al. Leuk Res Rep, 2015. PMID 26605150, Free PMC Article
  2. Germline genetic variation and treatment response on CCG-1891. Sepe DM, et al. Pediatr Blood Cancer, 2012 May. PMID 21618417, Free PMC Article
  3. Ethanol lowers glutathione in rat liver and brain and inhibits methionine synthase in a cobalamin-dependent manner. Waly MI, et al. Alcohol Clin Exp Res, 2011 Feb. PMID 21121936, Free PMC Article
  4. Aberrations in folate metabolic pathway and altered susceptibility to autism. Mohammad NS, et al. Psychiatr Genet, 2009 Aug. PMID 19440165
  5. Type I diabetes leads to tissue-specific DNA hypomethylation in male rats. Williams KT, et al. J Nutr, 2008 Nov. PMID 18936199

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables amino acid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables cobalamin binding IEA
Inferred from Electronic Annotation
more info
  
enables cobalamin binding TAS
Traceable Author Statement
more info
 PubMed 
enables folic acid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables methionine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methionine synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables methionine synthase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables methionine synthase activity ISO
Inferred from Sequence Orthology
more info
  
enables methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in axon regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to methionine IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to nitric oxide IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cobalamin metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cobalamin metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in homocysteine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in homocysteine metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in homocysteine metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in methionine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in methionine biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within methionine biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in methionine biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in methionine metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in response to axon injury IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tetrahydrofolate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tetrahydrofolate metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tetrahydrofolate metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
methionine synthase
Names
MS
cobalamin-dependent methionine synthase
vitamin-B12 dependent methionine synthase
NP_110491.2
XP_038952033.1
XP_038952034.1
XP_038952035.1
XP_038952036.1
XP_063132840.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030864.2 → NP_110491.2  methionine synthase

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/Swiss-Prot
    Q9Z2Q4
    UniProtKB/TrEMBL
    A6KN29, G3V8A4
    Related
    ENSRNOP00000023973.3, ENSRNOT00000023974.6
    Conserved Domains (1) summary
    PRK09490
    Location:1 → 1249
    metH; B12-dependent methionine synthase; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    62911705..62996544
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039096105.2 → XP_038952033.1  methionine synthase isoform X1

    UniProtKB/Swiss-Prot
    Q9Z2Q4
    UniProtKB/TrEMBL
    A6KN29, G3V8A4
    Conserved Domains (1) summary
    PRK09490
    Location:1 → 1249
    metH; B12-dependent methionine synthase; Provisional

  2. XM_039096107.2 → XP_038952035.1  methionine synthase isoform X2

    UniProtKB/Swiss-Prot
    Q9Z2Q4
    Conserved Domains (1) summary
    PRK09490
    Location:1 → 1190
    metH; B12-dependent methionine synthase; Provisional

  3. XM_039096108.2 → XP_038952036.1  methionine synthase isoform X4

    UniProtKB/TrEMBL
    A6KN30
    Conserved Domains (1) summary
    PRK09490
    Location:1 → 853
    metH; B12-dependent methionine synthase; Provisional

  4. XM_039096106.2 → XP_038952034.1  methionine synthase isoform X1

    UniProtKB/Swiss-Prot
    Q9Z2Q4
    UniProtKB/TrEMBL
    A6KN29, G3V8A4
    Conserved Domains (1) summary
    PRK09490
    Location:1 → 1249
    metH; B12-dependent methionine synthase; Provisional

  5. XM_063276770.1 → XP_063132840.1  methionine synthase isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z2Q4.1 GenPept UniProtKB/Swiss-Prot:Q9Z2Q4

Gene LinkOut

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