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Tfcp2l1 transcription factor CP2-like 1 [ Mus musculus (house mouse) ]

Gene ID: 81879, updated on 10-Mar-2024

Summary

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Official Symbol
Tfcp2l1provided by MGI
Official Full Name
transcription factor CP2-like 1provided by MGI
Primary source
MGI:MGI:2444691
See related
Ensembl:ENSMUSG00000026380 AllianceGenome:MGI:2444691
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cp2l1; LBP-9; Crtr-1; Tcfcp2l1; 1810030F05Rik; 4932442M07Rik; D930018N21Rik
Summary
Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including determination of adult lifespan; epithelial cell maturation; and negative regulation of transcription by RNA polymerase II. Located in cytoplasm; membrane; and nucleus. Is expressed in early conceptus; genitourinary system; heart; and limb. Orthologous to human TFCP2L1 (transcription factor CP2 like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 29.5), colon adult (RPKM 24.0) and 8 other tissues See more
Orthologs
human all
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Genomic context

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See Tfcp2l1 in Genome Data Viewer
Location:
1 E2.3; 1 52.14 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (118555646..118612898)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (118627923..118685168)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2900060B14 gene Neighboring gene CLIP associating protein 1 Neighboring gene STARR-positive B cell enhancer mm9_chr1:120355892-120356193 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:120356261-120356370 Neighboring gene predicted gene, 26080 Neighboring gene STARR-seq mESC enhancer starr_01983 Neighboring gene STARR-seq mESC enhancer starr_01987 Neighboring gene STARR-seq mESC enhancer starr_01991 Neighboring gene STARR-seq mESC enhancer starr_01996 Neighboring gene predicted gene, 23497 Neighboring gene STARR-seq mESC enhancer starr_01999 Neighboring gene GLI-Kruppel family member GLI2 Neighboring gene predicted gene, 51642 Neighboring gene microRNA 6346 Neighboring gene STARR-seq mESC enhancer starr_02009 Neighboring gene STARR-seq mESC enhancer starr_02012 Neighboring gene STARR-seq mESC enhancer starr_02016 Neighboring gene predicted gene, 41934

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TFCP2L1 represses multiple lineage commitment of mouse embryonic stem cells through MTA1 and LEF1. Liu K, et al. J Cell Sci, 2017 Nov 15. PMID 28982712
  2. Functional Analysis of CP2-Like Domain and SAM-Like Domain in TFCP2L1, Novel Pluripotency Factor of Embryonic Stem Cells. Kim CM, et al. Appl Biochem Biotechnol, 2016 Jun. PMID 26906118
  3. Embryonic stem cell self-renewal pathways converge on the transcription factor Tfcp2l1. Ye S, et al. EMBO J, 2013 Oct 2. PMID 23942238, Free PMC Article
  4. The transcription factor Tfcp2l1 promotes primordial germ cell-like cell specification of pluripotent stem cells. Zhang M, et al. J Biol Chem, 2021 Oct. PMID 34555410, Free PMC Article
  5. The transcription factor TFCP2L1 induces expression of distinct target genes and promotes self-renewal of mouse and human embryonic stem cells. Wang X, et al. J Biol Chem, 2019 Apr 12. PMID 30782842, Free PMC Article

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hypoxia-induced immortalization of primary cells depends on Tfcp2L1 expression.
    Title: Hypoxia-induced immortalization of primary cells depends on Tfcp2L1 expression.
  2. Temporal and spatial staging of lung alveolar regeneration is determined by the grainyhead transcription factor Tfcp2l1.
    Title: Temporal and spatial staging of lung alveolar regeneration is determined by the grainyhead transcription factor Tfcp2l1.
  3. Requirement for STAT3 and its target, TFCP2L1, in self-renewal of naive pluripotent stem cells in vivo and in vitro.
    Title: Requirement for STAT3 and its target, TFCP2L1, in self-renewal of naïve pluripotent stem cells in vivo and in vitro.
  4. MK2 promotes Tfcp2l1 degradation via beta-TrCP ubiquitin ligase to regulate mouse embryonic stem cell self-renewal.
    Title: MK2 promotes Tfcp2l1 degradation via β-TrCP ubiquitin ligase to regulate mouse embryonic stem cell self-renewal.
  5. The transcription factor Tfcp2l1 promotes primordial germ cell-like cell specification of pluripotent stem cells.
    Title: The transcription factor Tfcp2l1 promotes primordial germ cell-like cell specification of pluripotent stem cells.
  6. These findings indicate that TFCP2L1 functions differently in naive and primed pluripotency, insights that may help elucidate the different states of pluripotency.
    Title: The transcription factor TFCP2L1 induces expression of distinct target genes and promotes self-renewal of mouse and human embryonic stem cells.
  7. Thus, Tfcp2l1 is a critical regulator of intercalated cell-principal cell patterning in kidney collecting ducts, acting cell-autonomously in intercalated cells, and non-cell-autonomously in principal cells.
    Title: Transcription factor TFCP2L1 patterns cells in the mouse kidney collecting ducts.
  8. TFCP2L1 depends on its N-terminus and CP2-like domain to maintain the undifferentiated state of mouse embryonic stem cells.
    Title: TFCP2L1 represses multiple lineage commitment of mouse embryonic stem cells through MTA1 and LEF1.
  9. we found that TFCP2L1 is hexamerized in solution via the C-terminal SAM-like domain. We also found that homo-oligomerization of SAM-like domain is dependent on the concentration of the proteins.
    Title: Functional Analysis of CP2-Like Domain and SAM-Like Domain in TFCP2L1, Novel Pluripotency Factor of Embryonic Stem Cells.
  10. study therefore establishes the pivotal role of Klf2 and Tfcp2l1 in mediating ESC self-renewal promoted by Wnt/beta-catenin signaling.
    Title: Klf2 and Tfcp2l1, Two Wnt/β-Catenin Targets, Act Synergistically to Induce and Maintain Naive Pluripotency.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cytoplasm organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within epithelial cell maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within salivary gland development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription regulator complex ISA
Inferred from Sequence Alignment
more info
 PubMed 

General protein information

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Preferred Names
transcription factor CP2-like protein 1
Names
CP2-related transcriptional repressor 1
Tcfcp2-related transcriptional repressor 1
transcription repressor CRTR-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023755.2 → NP_076244.2  transcription factor CP2-like protein 1

    See identical proteins and their annotated locations for NP_076244.2

    Status: VALIDATED

    Source sequence(s)
    AC109271, AK143960, BC116663, BY707692, CF621828
    Consensus CDS
    CCDS35691.1
    UniProtKB/Swiss-Prot
    Q14AW3, Q3UNW5, Q99PF2
    Related
    ENSMUSP00000027629.9, ENSMUST00000027629.10
    Conserved Domains (2) summary
    cd09590
    Location:310 → 376
    SAM_LBP9; SAM domain of LBP9 transcriptional factors
    pfam04516
    Location:34 → 237
    CP2; CP2 transcription factor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    118555646..118612898
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529961.3 → XP_006530024.1  transcription factor CP2-like protein 1 isoform X1

    Conserved Domains (2) summary
    cd09590
    Location:259 → 325
    SAM_LBP9; SAM domain of LBP9 transcriptional factors
    pfam04516
    Location:31 → 186
    CP2; CP2 transcription factor
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UNW5.2 GenPept UniProtKB/Swiss-Prot:Q3UNW5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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