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NCOA3 nuclear receptor coactivator 3 [ Homo sapiens (human) ]

Gene ID: 8202, updated on 11-Apr-2024

Summary

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Official Symbol
NCOA3provided by HGNC
Official Full Name
nuclear receptor coactivator 3provided by HGNC
Primary source
HGNC:HGNC:7670
See related
Ensembl:ENSG00000124151 MIM:601937; AllianceGenome:HGNC:7670
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ACTR; AIB1; RAC3; SRC3; pCIP; AIB-1; CTG26; SRC-3; CAGH16; KAT13B; TNRC14; TNRC16; TRAM-1; bHLHe42
Summary
The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein. [provided by RefSeq, Mar 2010]
Annotation information
Note: RAC3 (Gene ID: 5881) and NCOA3 (Gene ID: 8202) share the RAC3 symbol/alias in common. RAC3 is a widely used alternative name for nuclear receptor coactivator 3 (NCOA3), which can be confused with the official symbol for ras-related C3 botulinum toxin substrate 3 (RAC3). [06 Jul 2018]
Expression
Ubiquitous expression in lymph node (RPKM 20.8), placenta (RPKM 19.0) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See NCOA3 in Genome Data Viewer
Location:
20q13.12
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (47501887..47656872)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (49240095..49395274)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (46130631..46285616)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17997 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17998 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17999 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12978 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12979 Neighboring gene RNA, U6 small nuclear 497, pseudogene Neighboring gene CRISPRi-validated cis-regulatory element chr20.2047 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12980 Neighboring gene RNA, U6 small nuclear 563, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:46152763-46153530 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46158187-46158687 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:46190110-46190292 Neighboring gene MPRA-validated peak4234 silencer Neighboring gene ribosomal protein S3A pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:46276897-46277614 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr20:46277615-46278332 Neighboring gene nuclear receptor coactivator 3 repeat instability region Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18000 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18001 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18002 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46293563-46294548 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46294549-46295532 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18003 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18004 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46303203-46304168 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46307531-46308031 Neighboring gene sulfatase 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:46316712-46317262 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:46317263-46317814 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:46326206-46326710 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18005 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46339340-46339840 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46339841-46340341 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18006 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46381087-46381588 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46381589-46382088 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46386138-46386895 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46386896-46387654 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46387655-46388411 Neighboring gene NANOG hESC enhancer GRCh37_chr20:46390145-46390683 Neighboring gene Sharpr-MPRA regulatory region 8498 Neighboring gene uncharacterized LOC124904922 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18007 Neighboring gene uncharacterized LOC124904920 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18008

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Non-Syndromic Autosomal Dominant Hearing Loss: The First Italian Family Carrying a Mutation in the NCOA3 Gene. Tesolin P, et al. Genes (Basel), 2021 Jul 6. PMID 34356059, Free PMC Article
  2. NCOA3 is a critical oncogene in thyroid cancer via the modulation of major signaling pathways. Li Y, et al. Endocrine, 2022 Jan. PMID 34251576
  3. SRC-3, a Steroid Receptor Coactivator: Implication in Cancer. Li L, et al. Int J Mol Sci, 2021 Apr 30. PMID 33946224, Free PMC Article
  4. Nuclear Receptor Coactivator NCOA3 Regulates UV Radiation-Induced DNA Damage and Melanoma Susceptibility. de Semir D, et al. Cancer Res, 2021 Jun 1. PMID 33766890, Free PMC Article
  5. Upregulation of amplified in breast cancer 1 contributes to pancreatic ductal adenocarcinoma progression and vulnerability to blockage of hedgehog activation. Li L, et al. Theranostics, 2021. PMID 33408774, Free PMC Article

See all (418) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Protective role of circRNA CCND1 in ulcerative colitis via miR-142-5p/NCOA3 axis.
    Title: Protective role of circRNA CCND1 in ulcerative colitis via miR-142-5p/NCOA3 axis.
  2. ZFP64::NCOA3 gene fusion defines a novel subset of spindle cell rhabdomyosarcoma.
    Title: ZFP64::NCOA3 gene fusion defines a novel subset of spindle cell rhabdomyosarcoma.
  3. NCOA3 is a critical oncogene in thyroid cancer via the modulation of major signaling pathways.
    Title: NCOA3 is a critical oncogene in thyroid cancer via the modulation of major signaling pathways.
  4. PAX2 promoter methylation and AIB1 overexpression promote tamoxifen resistance in breast carcinoma patients.
    Title: PAX2 promoter methylation and AIB1 overexpression promote tamoxifen resistance in breast carcinoma patients.
  5. Non-Syndromic Autosomal Dominant Hearing Loss: The First Italian Family Carrying a Mutation in the NCOA3 Gene.
    Title: Non-Syndromic Autosomal Dominant Hearing Loss: The First Italian Family Carrying a Mutation in the NCOA3 Gene.
  6. FBXL16 modulates the proliferation and autophagy in breast cancer cells via activating SRC-3-AKT signaling pathway.
    Title: FBXL16 modulates the proliferation and autophagy in breast cancer cells via activating SRC-3-AKT signaling pathway.
  7. An AIB1 Isoform Alters Enhancer Access and Enables Progression of Early-Stage Triple-Negative Breast Cancer.
    Title: An AIB1 Isoform Alters Enhancer Access and Enables Progression of Early-Stage Triple-Negative Breast Cancer.
  8. Functional relationship between CFTR and RAC3 expression for maintaining cancer cell stemness in human colorectal cancer.
    Title: Functional relationship between CFTR and RAC3 expression for maintaining cancer cell stemness in human colorectal cancer.
  9. PELP1/SRC-3-dependent regulation of metabolic PFKFB kinases drives therapy resistant ER(+) breast cancer.
    Title: PELP1/SRC-3-dependent regulation of metabolic PFKFB kinases drives therapy resistant ER(+) breast cancer.
  10. Steroid receptor coactivator 3 (SRC-3/AIB1) is enriched and functional in mouse and human Tregs.
    Title: Steroid receptor coactivator 3 (SRC-3/AIB1) is enriched and functional in mouse and human Tregs.
Submit: New GeneRIF Correction See all GeneRIFs (218)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip.
EBI GWAS Catalog
Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of nuclear receptor coactivator 3 (NCOA3) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat NCOA3 is downregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells PubMed
tat p/CIP binds to HIV-1 Tat and enhances Tat-stimulated HIV-1 LTR promoter transactivation PubMed
tat HIV-1 Tat may function as an adaptor molecule, efficiently stimulating the processes of transcription initiation and elongation through potentiation of the coupling of p160 co-activators and the P-TEFb complex PubMed
nucleocapsid gag Nuclear receptor coactivator 3 (NCOA3) is downregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC141848

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA polymerase II complex binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables disordered domain specific binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables histone acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nuclear receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nuclear receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables nuclear receptor coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear thyroid hormone receptor binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coactivator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell dedifferentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cellular response to estradiol stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to hormone stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of keratinocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of stem cell population maintenance ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in receptor transactivation TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of stem cell division ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
part_of chromatin ISA
Inferred from Sequence Alignment
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in extracellular exosome HDA PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
nuclear receptor coactivator 3
Names
CBP-interacting protein
amplified in breast cancer 1 protein
class E basic helix-loop-helix protein 42
receptor-associated coactivator 3
steroid receptor coactivator protein 3
thyroid hormone receptor activator molecule 1
NP_001167558.1
NP_001167559.1
NP_006525.2
NP_858045.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016810.2 RefSeqGene

    Range
    5002..159987
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001174087.2 → NP_001167558.1  nuclear receptor coactivator 3 isoform c

    See identical proteins and their annotated locations for NP_001167558.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site compared to variant 1, resulting in a shorter isoform (c) compared to isoform a.
    Source sequence(s)
    AL021394, AL034418, AL353777
    UniProtKB/TrEMBL
    Q569F6
    Conserved Domains (8) summary
    smart00091
    Location:116 → 173
    PAS; PAS domain
    cd18949
    Location:29 → 101
    bHLH-PAS_NCoA3_SRC3; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 3 (NCoA-3) and similar proteins
    pfam07469
    Location:1290 → 1347
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:1045 → 1091
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:616 → 704
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:265 → 375
    PAS_11; PAS domain
    pfam16279
    Location:723 → 810
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:459 → 572
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein

  2. NM_001174088.2 → NP_001167559.1  nuclear receptor coactivator 3 isoform d

    See identical proteins and their annotated locations for NP_001167559.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses three alternate in-frame splice sites compared to variant 1, resulting in a shorter isoform (d) compared to isoform a.
    Source sequence(s)
    AL021394, AL034418, AL353777
    Consensus CDS
    CCDS54472.1
    UniProtKB/TrEMBL
    Q0IIN7
    Related
    ENSP00000361065.3, ENST00000371997.3
    Conserved Domains (9) summary
    smart00353
    Location:34 → 88
    HLH; helix loop helix domain
    smart00091
    Location:116 → 173
    PAS; PAS domain
    pfam00989
    Location:117 → 215
    PAS; PAS fold
    pfam07469
    Location:1282 → 1339
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:1040 → 1087
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:630 → 714
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:265 → 385
    PAS_11; PAS domain
    pfam16279
    Location:733 → 820
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:469 → 582
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein

  3. NM_006534.4 → NP_006525.2  nuclear receptor coactivator 3 isoform b

    See identical proteins and their annotated locations for NP_006525.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1, resulting in a shorter isoform (b) compared to isoform a.
    Source sequence(s)
    AL021394, AL034418, AL353777
    Consensus CDS
    CCDS13406.1
    UniProtKB/TrEMBL
    Q0IIN7
    Related
    ENSP00000361073.1, ENST00000372004.7
    Conserved Domains (9) summary
    smart00353
    Location:34 → 88
    HLH; helix loop helix domain
    smart00091
    Location:116 → 173
    PAS; PAS domain
    pfam07469
    Location:1287 → 1344
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:1045 → 1092
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:620 → 704
    SRC-1; Steroid receptor coactivator
    pfam09606
    Location:1077 → 1364
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam14598
    Location:265 → 375
    PAS_11; PAS domain
    pfam16279
    Location:723 → 810
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:459 → 572
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein

  4. NM_181659.3 → NP_858045.1  nuclear receptor coactivator 3 isoform a

    See identical proteins and their annotated locations for NP_858045.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AL021394, AL034418, AL353777
    Consensus CDS
    CCDS13407.1
    UniProtKB/Swiss-Prot
    A4LAZ5, Q0VF45, Q5JYD9, Q5JYE0, Q9BR49, Q9UPC9, Q9UPG4, Q9UPG7, Q9Y6Q9
    UniProtKB/TrEMBL
    A8K0W8
    Related
    ENSP00000361066.3, ENST00000371998.8
    Conserved Domains (9) summary
    smart00353
    Location:34 → 88
    HLH; helix loop helix domain
    smart00091
    Location:116 → 173
    PAS; PAS domain
    pfam00989
    Location:117 → 215
    PAS; PAS fold
    pfam07469
    Location:1291 → 1348
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:1045 → 1092
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:620 → 704
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:265 → 375
    PAS_11; PAS domain
    pfam16279
    Location:723 → 810
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:459 → 572
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    47501887..47656872
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    49240095..49395274
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y6Q9.1 GenPept UniProtKB/Swiss-Prot:Q9Y6Q9

Gene LinkOut

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