Tas1r2 taste receptor, type 1, member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tas1r2provided by MGI
Official Full Name: taste receptor, type 1, member 2provided by MGI
Primary source: MGI:MGI:1933546
See related: Ensembl:ENSMUSG00000028738 AllianceGenome:MGI:1933546
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TR2; T1r2; Gpr71
Summary: Enables sweet taste receptor activity. Acts upstream of or within sensory perception of sweet taste. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be part of sweet taste receptor complex. Predicted to be integral component of plasma membrane. Is expressed in tongue anterior part. Orthologous to human TAS1R2 (taste 1 receptor member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 4 D3; 4 70.82 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (139380849..139397591)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (139653538..139670280)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sweet taste perception in mice is blunted by PTBP1-regulated skipping of Tas1r2 exon 4.
Title: Sweet taste perception in mice is blunted by PTBP1-regulated skipping of Tas1r2 exon 4.
Current Progress in Understanding the Structure and Function of Sweet Taste Receptor.
Title: Current Progress in Understanding the Structure and Function of Sweet Taste Receptor.
Using T1R2-knock out (KO) mice authors evaluated the role of STRs in the regulation of glucose absorption in vivo and in intact intestinal preparations ex vivo.
Title: T1R2 receptor-mediated glucose sensing in the upper intestine potentiates glucose absorption through activation of local regulatory pathways.
our platform provides in depth analysis of new sweeteners either alone or in competition and/or inhibition studies to fully understand the structure/functional role of ATD region of T1R2 that transpires in the initial binding event prior to sweet taste response.
Title: Multimodal Ligand Binding Studies of Human and Mouse G-Coupled Taste Receptors to Correlate Their Species-Specific Sweetness Tasting Properties.
Data suggest that Tas1r2 and Tas1r3 are involved in regulation of Glp1 secretion in enteroendocrine cells; 3DG (3-deoxyglucosone) attenuates high glucose-stimulated Glp1 secretion by antagonizing Tas1r2/Tas1r3 subunits and downstream cAMP signaling. (Tas1r2 = sweet taste receptor subunit Tas1r2; Tas1r3 = sweet taste receptor subunit Tas1r3; Glp1 = glucagon-like peptide-1)
Title: The downregulation of sweet taste receptor signaling in enteroendocrine L-cells mediates 3-deoxyglucosone-induced attenuation of high glucose-stimulated GLP-1 secretion.
Data, including data from studies with mutant and knockout mice, suggest that Tas1R3 and Tas1R2 are expressed endogenously in osteoclast stem cells; their expression levels parallel robust increase in osteoclast biomarker Ctsk during osteoclast differentiation. (Ctsk = cathepsin K)
Title: Loss of the nutrient sensor TAS1R3 leads to reduced bone resorption.
mice lacking T1R2 + T1R3 and controls were tested in a taste discrimination task to determine whether maltodextrins are 1) detectable when both receptor subunits are absent and 2) perceptually distinct from that of sucrose. Some KO mice were only sensitive to the higher Polycose concentrations, implicating potential allelic variation in the putative polysaccharide receptor pathways unmasked by the absence of T1R2+T1R3.
Title: Detection of maltodextrin and its discrimination from sucrose are independent of the T1R2 + T1R3 heterodimer.
results implicate each subunit of the T1R2+T1R3 dimer in the behavioral response to P-containing taste compounds
Title: Phosphorus Taste Involves T1R2 and T1R3.
T1R2 plays an important role in glucose homeostasis during diet-induced obesity through the regulation of yet to be identified molecular mechanisms that alter energy disposal and utilization in peripheral tissues. T1r2 was upregulated in the adipose tissue of wild type mice in response to high fat/low carbohydrate diet, and their expression positively correlated with fat mass and glucose intolerance.
Title: Disruption of the sugar-sensing receptor T1R2 attenuates metabolic derangements associated with diet-induced obesity.
Mice possess two taste transduction pathways for sugars. One mediates behavioral attraction to sugars and requires an intact T1r2+T1r3. The other mediates cephalic phase insulin release but does not require an intact T1r2+T1r3.
Title: Sugar-induced cephalic-phase insulin release is mediated by a T1r2+T1r3-independent taste transduction pathway in mice.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to sweet taste receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables sweet taste receptor activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to sweet taste receptor activity	ISO Inferred from Sequence Orthology more info
contributes_to taste receptor activity	ISO Inferred from Sequence Orthology more info
enables taste receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in detection of chemical stimulus involved in sensory perception of sweet taste	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokinesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to stimulus	IEA Inferred from Electronic Annotation more info
involved_in sensory perception of sweet taste	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sensory perception of sweet taste	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sensory perception of sweet taste	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sensory perception of taste	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info	PubMed
part_of sweet taste receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of sweet taste receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: taste receptor type 1 member 2

Names: G-protein coupled receptor 71; candidate taste receptor T1R2; sweet taste receptor T1R2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031873.1 → NP_114079.1 taste receptor type 1 member 2 precursor

See identical proteins and their annotated locations for NP_114079.1

Status: PROVISIONAL

Source sequence(s)

AF337041

Consensus CDS

CCDS18849.1

UniProtKB/Swiss-Prot

B1AXX0, Q923J8, Q925I4

UniProtKB/TrEMBL

E9Q0R6

Related

ENSMUSP00000030510.8, ENSMUST00000030510.14

Conserved Domains (4) summary

pfam00003
Location:581 → 818

7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

pfam01094
Location:73 → 458

ANF_receptor; Receptor family ligand binding region

pfam07562
Location:496 → 547

NCD3G; Nine Cysteines Domain of family 3 GPCR

cl10011
Location:30 → 487

Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily