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FCAMR Fc alpha and mu receptor [ Homo sapiens (human) ]

Gene ID: 83953, updated on 5-Mar-2024

Summary

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Official Symbol
FCAMRprovided by HGNC
Official Full Name
Fc alpha and mu receptorprovided by HGNC
Primary source
HGNC:HGNC:24692
See related
Ensembl:ENSG00000162897 MIM:605484; AllianceGenome:HGNC:24692
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD351; FCA/MR; FKSG87; Fcalpha/muR
Summary
Predicted to enable IgA binding activity; IgM binding activity; and transmembrane signaling receptor activity. Predicted to be involved in adaptive immune response. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney (RPKM 16.8), lymph node (RPKM 10.8) and 4 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
1q32.1
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (206957967..206970638, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (206223168..206235839, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (207131312..207143805, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1768 Neighboring gene negCOR silencer S10 Neighboring gene ribosomal protein L13a pseudogene 8 Neighboring gene Fc mu receptor Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2427 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2428 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2429 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2430 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2431 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2432 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2433 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2434 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:207103683-207104183 Neighboring gene polymeric immunoglobulin receptor Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1769 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:207134913-207136112 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2437 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2438 Neighboring gene tRNA-Pro (anticodon TGG) 5-1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:207192892-207194091 Neighboring gene chromosome 1 open reading frame 116

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Genome-Wide Association Studies for Taxane-Induced Peripheral Neuropathy in ECOG-5103 and ECOG-1199. Schneider BP, et al. Clin Cancer Res, 2015 Nov 15. PMID 26138065, Free PMC Article
  2. Immunoglobulin A in serum: an old acquaintance as a new prognostic biomarker in idiopathic pulmonary fibrosis. Ten Klooster L, et al. Clin Exp Immunol, 2015 Aug. PMID 25845491, Free PMC Article
  3. Requirement of the cytoplasmic portion for dimer formation of Fcalpha/micro receptor expressed on cell surface. Cho Y, et al. Mol Immunol, 2010 Jan. PMID 19945166
  4. Cytoplasmic domain of human Fcalpha/mu receptor is required for ligand internalization. Yang L, et al. Cell Immunol, 2009. PMID 19393604
  5. Expression of Fc alpha/mu receptor by human mesangial cells: a candidate receptor for immune complex deposition in IgA nephropathy. McDonald KJ, et al. Biochem Biophys Res Commun, 2002 Jan 11. PMID 11779189

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A genome-wide trans-ethnic interaction study links the PIGR-FCAMR locus to coronary atherosclerosis via interactions between genetic variants and residential exposure to traffic pollution.
    Title: A genome-wide trans-ethnic interaction study links the PIGR-FCAMR locus to coronary atherosclerosis via interactions between genetic variants and residential exposure to traffic.
  2. rs3125923 FCAMR gene represents a validated SNP to predict grade 3-4 Taxane-induced peripheral neuropathy . Genetically determined AA race represents the most significant predictor of TIPN.
    Title: Genome-Wide Association Studies for Taxane-Induced Peripheral Neuropathy in ECOG-5103 and ECOG-1199.
  3. A significantly worse survival was found in patients with IgA serum levels>2.85 g/l compared to patients with lower IgA serum levels.
    Title: Immunoglobulin A in serum: an old acquaintance as a new prognostic biomarker in idiopathic pulmonary fibrosis.
  4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  5. ADAM10 and ADAM17 are involved in the shedding of FcalphaR
    Title: Ectodomain shedding of Fcalpha receptor is mediated by ADAM10 and ADAM17.
  6. LPS, through the TLR4 receptor, activates the p38MAPK and NF-kappaB pathways and up-regulate the expression of Fcamr in human macrophages
    Title: Lipopolysaccharide up-regulates the expression of Fcalpha/mu receptor and promotes the binding of oxidized low-density lipoprotein and its IgM antibody complex to activated human macrophages.
  7. These results suggest that the cytoplasmic portion is required for the dimer formation and thus for efficient cell surface expression of Fcalpha/microR.
    Title: Requirement of the cytoplasmic portion for dimer formation of Fcalpha/micro receptor expressed on cell surface.
  8. the cytoplasmic portion of human Fcalpha/microR is required in the internalization.
    Title: Cytoplasmic domain of human Fcalpha/mu receptor is required for ligand internalization.
  9. These results indicate for the first time that Fcalpha/muR protein is expressed by human intestinal tissues
    Title: Human Fcalpha/muR and pIgR distribute differently in intestinal tissues.
  10. Comprehensive survey of naturally occurring polymorphisms in rhesus macaques and in humans.
    Title: Human expression variation in the mu-opioid receptor is paralleled in rhesus macaque.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Preincubation of monocytes with HIV-1 gp120 depresses anti-CD3 antibody-induced T cell stimulation and Fc receptor-mediated phagocytosis PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor
Names
Fc alpha/mu receptor
Fc fragment of IgA and IgM receptor
Fc receptor, IgA, IgM, high affinity
immunity related factor
receptor for Fc fragment of IgA and IgM

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122979.3 → NP_001116451.1  high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor isoform a

    See identical proteins and their annotated locations for NP_001116451.1

    Status: VALIDATED

    Source sequence(s)
    AC098935, AI269147, BC109263, BX090153, CD633520
    Consensus CDS
    CCDS41460.1
    UniProtKB/Swiss-Prot
    Q8WWV6
    Related
    ENSP00000392707.2, ENST00000450945.3
    Conserved Domains (2) summary
    cd05716
    Location:114 → 214
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:112 → 215
    IG_like; Immunoglobulin like

  2. NM_001170631.2 → NP_001164102.1  high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor isoform b

    See identical proteins and their annotated locations for NP_001164102.1

    Status: VALIDATED

    Source sequence(s)
    AI269147, AK298394
    Consensus CDS
    CCDS53468.1
    UniProtKB/TrEMBL
    A0A0B4J1S2
    Related
    ENSP00000316491.4, ENST00000324852.9
    Conserved Domains (2) summary
    cd05716
    Location:114 → 214
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:112 → 215
    IG_like; Immunoglobulin like

  3. NM_001424868.1 → NP_001411797.1  high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor isoform c precursor

    Status: VALIDATED

    Description
    Transcript Variant: Contains an N-terminal signal peptide sequence (MPLFLILCLLQGSSFA) supported by SignalP as well as PMID: 11062505 and PMID: 20059578.
    Source sequence(s)
    AC098935
    UniProtKB/Swiss-Prot
    Q32M82, Q8WWV5, Q8WWV6, Q96SA2

  4. NM_032029.5 → NP_114418.2  high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor isoform a

    See identical proteins and their annotated locations for NP_114418.2

    Status: VALIDATED

    Source sequence(s)
    AC098935, AI269147, BC109263, BX090153, DC361666
    Consensus CDS
    CCDS41460.1
    UniProtKB/Swiss-Prot
    Q8WWV6
    Related
    ENSP00000383746.3, ENST00000400962.8
    Conserved Domains (2) summary
    cd05716
    Location:114 → 214
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:112 → 215
    IG_like; Immunoglobulin like

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    206957967..206970638 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047431769.1 → XP_047287725.1  high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor isoform X1

    UniProtKB/TrEMBL
    A0A0B4J1S2

  2. XM_011510051.3 → XP_011508353.1  high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor isoform X1

    See identical proteins and their annotated locations for XP_011508353.1

    UniProtKB/TrEMBL
    A0A0B4J1S2
    Conserved Domains (2) summary
    cd05716
    Location:114 → 214
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:112 → 215
    IG_like; Immunoglobulin like

  3. XM_047431771.1 → XP_047287727.1  high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor isoform X3

  4. XM_011510052.3 → XP_011508354.1  high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor isoform X2

    Conserved Domains (2) summary
    cd05716
    Location:102 → 202
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:100 → 203
    IG_like; Immunoglobulin like

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    206223168..206235839 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054339061.1 → XP_054195036.1  high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor isoform X1

    UniProtKB/TrEMBL
    A0A0B4J1S2

  2. XM_054339063.1 → XP_054195038.1  high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor isoform X3

  3. XM_054339062.1 → XP_054195037.1  high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor isoform X2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001122980.1: Suppressed sequence

    Description
    NM_001122980.1: This RefSeq was permanently suppressed because it represents a transcript produced via non-consensus splicing and there is limited support for that atypical event.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8WWV6.1 GenPept UniProtKB/Swiss-Prot:Q8WWV6

Gene LinkOut

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