U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LZIC leucine zipper and CTNNBIP1 domain containing [ Homo sapiens (human) ]

Gene ID: 84328, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
LZICprovided by HGNC
Official Full Name
leucine zipper and CTNNBIP1 domain containingprovided by HGNC
Primary source
HGNC:HGNC:17497
See related
Ensembl:ENSG00000162441 MIM:610458; AllianceGenome:HGNC:17497
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable beta-catenin binding activity. Predicted to be involved in response to ionizing radiation. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 8.7), colon (RPKM 7.1) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
1p36.22
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (9922118..9943391, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (9465032..9486296, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (9982176..10003449, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376717 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:9911316-9912116 Neighboring gene catenin beta interacting protein 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:9919701-9920595 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9931412-9932340 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9932341-9933268 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 236 Neighboring gene uncharacterized LOC124903838 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 140 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:9943986-9944775 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:9946851-9947439 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9960261-9960762 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 238 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 239 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 237 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:9970922-9971595 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9971596-9972268 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:9987872-9988381 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:9990871-9991370 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:9998882-9999382 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:9999383-9999883 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:10002582-10003781 Neighboring gene RN7SK pseudogene 269 Neighboring gene nicotinamide nucleotide adenylyltransferase 1 Neighboring gene transmembrane protein 274, pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Leucine zipper and ICAT domain containing (LZIC) protein regulates cell cycle transitions in response to ionizing radiation. Skalka G, et al. Cell Cycle, 2019 May. PMID 30973299, Free PMC Article
  2. Molecular cloning and characterization of LZIC, a novel gene encoding ICAT homologous protein with leucine zipper domain. Katoh M. Int J Mol Med, 2001 Dec. PMID 11712074
  3. Identification of sequence-tagged transcripts differentially expressed within the human hematopoietic hierarchy. Claudio JO, et al. Genomics, 1998 May 15. PMID 9628821
  4. Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers. Arumughan A, et al. Nat Commun, 2016 Oct 20. PMID 27762274, Free PMC Article
  5. Expanding the substantial interactome of NEMO using protein microarrays. Fenner BJ, et al. PLoS One, 2010 Jan 20. PMID 20098747, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LZIC is functionally involved in cellular response to ionizing radiation, and its expression level could serve as a biomarker for patient stratification in clinical cancer practice.
    Title: Leucine zipper and ICAT domain containing (LZIC) protein regulates cell cycle transitions in response to ionizing radiation.
  2. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  3. Observational study of gene-disease association. (HuGE Navigator)
    Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC15436

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables beta-catenin binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
protein LZIC
Names
leucine zipper and CTNNBIP1 domain-containing protein
leucine zipper and ICAT homologous domain-containing protein
leucine zipper domain and ICAT homologous domain containing

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316973.2 → NP_001303902.1  protein LZIC isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AK312550, AL357140, CB241987, DA538145
    Consensus CDS
    CCDS107.1
    UniProtKB/Swiss-Prot
    B2R6F0, B4E2N0, Q8WZA0, Q96IU1
    Related
    ENSP00000366418.1, ENST00000377213.1
    Conserved Domains (1) summary
    pfam06384
    Location:113 → 188
    ICAT; Beta-catenin-interacting protein ICAT

  2. NM_001316974.2 → NP_001303903.1  protein LZIC isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses two alternate splice junctions in the 5' end compared to variant 1. The resulting isoform (b) is longer at the N-terminus compared to isoform a.
    Source sequence(s)
    AK304348, AL357140, CB241987, DA538145
    UniProtKB/Swiss-Prot
    Q8WZA0
    Conserved Domains (1) summary
    pfam06384
    Location:134 → 209
    ICAT; Beta-catenin-interacting protein ICAT

  3. NM_001316975.2 → NP_001303904.1  protein LZIC isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate terminal exon compared to variant 1. The resulting isoform (c) has a longer and distinct C-terminus compared to isoform a.
    Source sequence(s)
    BI772110, BQ018333, DA538145
    UniProtKB/TrEMBL
    K7ES95
    Related
    ENSP00000468610.1, ENST00000488540.5
    Conserved Domains (1) summary
    pfam06384
    Location:113 → 172
    ICAT; Beta-catenin-interacting protein ICAT

  4. NM_001316976.2 → NP_001303905.1  protein LZIC isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and lacks two alternate coding exons compared to variant 1. The resulting isoform (d) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AL357140, CB241987, DA538145, DB106543
    Conserved Domains (1) summary
    pfam04111
    Location:8 → 87
    APG6; Autophagy protein Apg6

  5. NM_032368.5 → NP_115744.2  protein LZIC isoform a

    See identical proteins and their annotated locations for NP_115744.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AA220235, AL357140, BC007240, CB241987
    Consensus CDS
    CCDS107.1
    UniProtKB/Swiss-Prot
    B2R6F0, B4E2N0, Q8WZA0, Q96IU1
    Related
    ENSP00000366430.1, ENST00000377223.6
    Conserved Domains (1) summary
    pfam06384
    Location:113 → 188
    ICAT; Beta-catenin-interacting protein ICAT

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    9922118..9943391 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005263506.3 → XP_005263563.1  protein LZIC isoform X1

    See identical proteins and their annotated locations for XP_005263563.1

    UniProtKB/TrEMBL
    K7ES95
    Conserved Domains (1) summary
    pfam06384
    Location:113 → 172
    ICAT; Beta-catenin-interacting protein ICAT

  2. XM_017002546.2 → XP_016858035.1  protein LZIC isoform X2

    Conserved Domains (2) summary
    pfam06384
    Location:113 → 171
    ICAT; Beta-catenin-interacting protein ICAT
    pfam04111
    Location:8 → 87
    APG6; Autophagy protein Apg6

  3. XM_017002547.2 → XP_016858036.1  protein LZIC isoform X2

    Conserved Domains (2) summary
    pfam06384
    Location:113 → 171
    ICAT; Beta-catenin-interacting protein ICAT
    pfam04111
    Location:8 → 87
    APG6; Autophagy protein Apg6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    9465032..9486296 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054339191.1 → XP_054195166.1  protein LZIC isoform X1

  2. XM_054339193.1 → XP_054195168.1  protein LZIC isoform X2

  3. XM_054339192.1 → XP_054195167.1  protein LZIC isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8WZA0.1 GenPept UniProtKB/Swiss-Prot:Q8WZA0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous