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AOPEP aminopeptidase O (putative) [ Homo sapiens (human) ]

Gene ID: 84909, updated on 5-Mar-2024

Summary

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Official Symbol
AOPEPprovided by HGNC
Official Full Name
aminopeptidase O (putative)provided by HGNC
Primary source
HGNC:HGNC:1361
See related
Ensembl:ENSG00000148120 MIM:619600; AllianceGenome:HGNC:1361
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APO; AP-O; DYT31; ONPEP; C90RF3; C9orf3
Summary
This gene encodes a member of the M1 zinc aminopeptidase family. The encoded protein is a zinc-dependent metallopeptidase that catalyzes the removal of an amino acid from the amino terminus of a protein or peptide. This protein may play a role in the generation of angiotensin IV. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2010]
Expression
Ubiquitous expression in skin (RPKM 4.6), endometrium (RPKM 4.2) and 24 other tissues See more
Orthologs
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Genomic context

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See AOPEP in Genome Data Viewer
Location:
9q22.32
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (94726699..95150224)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (106896013..107317676)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (97488981..97849441)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene NANOG hESC enhancer GRCh37_chr9:97370327-97370828 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:97372257-97372756 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20057 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28632 Neighboring gene Sharpr-MPRA regulatory region 4124 Neighboring gene uncharacterized LOC124902219 Neighboring gene fructose-bisphosphatase 1 Neighboring gene uncharacterized LOC107987101 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr9:97482699-97483898 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:97488708-97489250 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:97506143-97506644 Neighboring gene uncharacterized LOC124902220 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28635 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:97587461-97588134 Neighboring gene microRNA 2278 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28636 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_110389 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:97634019-97634518 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_110405 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_110431 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:97678815-97679315 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:97680413-97680914 Neighboring gene uncharacterized LOC101928119 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:97689588-97690377 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:97690378-97691166 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:97691883-97692383 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:97712716-97712894 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20058 Neighboring gene Sharpr-MPRA regulatory region 10357 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:97741836-97742834 Neighboring gene Sharpr-MPRA regulatory region 2222 Neighboring gene Sharpr-MPRA regulatory region 14176 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20061 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20060 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20059 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:97780096-97781295 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:97785561-97786760 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:97791169-97791319 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:97794537-97795036 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:97807172-97807937 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20062 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:97825060-97825769 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:97852235-97852984 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:97853735-97854484 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:97852985-97853734 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:97863941-97864440 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:97865305-97865951 Neighboring gene uncharacterized LOC107987102 Neighboring gene microRNA 6081 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20063 Neighboring gene Sharpr-MPRA regulatory region 10736 Neighboring gene Sharpr-MPRA regulatory region 8238 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:97894463-97894965 Neighboring gene microRNA 3074 Neighboring gene microRNA 24-1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:97900452-97901082 Neighboring gene microRNA 27b Neighboring gene microRNA 23b Neighboring gene ribosomal protein S26 pseudogene 37 Neighboring gene FA complementation group C Neighboring gene RNA, 5S ribosomal pseudogene 288 Neighboring gene small nucleolar RNA U13 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_110513 Neighboring gene Sharpr-MPRA regulatory region 1665 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_110548 Neighboring gene Sharpr-MPRA regulatory region 1693 Neighboring gene ATM interactor pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Mutation screening of AOPEP variants in a large dystonia cohort. Lin J, et al. J Neurol, 2023 Jun. PMID 36933031
  2. AOPEP variants as a novel cause of recessive dystonia: Generalized dystonia and dystonia-parkinsonism. Garavaglia B, et al. Parkinsonism Relat Disord, 2022 Apr. PMID 35306330
  3. Suicide Related Phenotypes in a Bipolar Sample: Genetic Underpinnings. Lybech LKM, et al. Genes (Basel), 2021 Sep 23. PMID 34680877, Free PMC Article
  4. Biallelic AOPEP Loss-of-Function Variants Cause Progressive Dystonia with Prominent Limb Involvement. Zech M, et al. Mov Disord, 2022 Jan. PMID 34596301
  5. An association study of C9orf3, a novel component of the renin-angiotensin system, and hypertension in diabetes. Ichikawa M, et al. Sci Rep, 2020 Sep 30. PMID 32999396, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mutation screening of AOPEP variants in a large dystonia cohort.
    Title: Mutation screening of AOPEP variants in a large dystonia cohort.
  2. AOPEP variants as a novel cause of recessive dystonia: Generalized dystonia and dystonia-parkinsonism.
    Title: AOPEP variants as a novel cause of recessive dystonia: Generalized dystonia and dystonia-parkinsonism.
  3. Biallelic AOPEP Loss-of-Function Variants Cause Progressive Dystonia with Prominent Limb Involvement.
    Title: Biallelic AOPEP Loss-of-Function Variants Cause Progressive Dystonia with Prominent Limb Involvement.
  4. Suicide Related Phenotypes in a Bipolar Sample: Genetic Underpinnings.
    Title: Suicide Related Phenotypes in a Bipolar Sample: Genetic Underpinnings.
  5. An association study of C9orf3, a novel component of the renin-angiotensin system, and hypertension in diabetes.
    Title: An association study of C9orf3, a novel component of the renin-angiotensin system, and hypertension in diabetes.
  6. HPV-16 E6 was confirmed to regulate microRNA miR-23b indirectly through the DNA methylation of host gene C9orf3 and thus induce c-MET and inhibit apoptosis in cervical cancer cells.
    Title: Human papillomavirus type 16 E6 suppresses microRNA-23b expression in human cervical cancer cells through DNA methylation of the host gene C9orf3.
  7. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Dystonia 31
MedGen: C5562001 OMIM: 619565 GeneReviews: Not available
not available

EBI GWAS Catalog

Description
Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome.
EBI GWAS Catalog
Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer.
EBI GWAS Catalog
Meta-analysis identifies six new susceptibility loci for atrial fibrillation.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ14675, FLJ40923, FLJ55832

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metalloaminopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
aminopeptidase O

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027833.2 RefSeqGene

    Range
    5002..365462
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001193329.3 → NP_001180258.1  aminopeptidase O isoform 1

    See identical proteins and their annotated locations for NP_001180258.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL157936, AL353768, AL354893
    Consensus CDS
    CCDS55328.1
    UniProtKB/Swiss-Prot
    Q5T9B1, Q5T9B3, Q5T9B4, Q8N6M6, Q8WUL6, Q96M23, Q96SS1
    Related
    ENSP00000364464.2, ENST00000375315.8
    Conserved Domains (2) summary
    pfam09127
    Location:721 → 818
    Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
    cl14813
    Location:244 → 652
    GluZincin; Gluzincin Peptidase family (thermolysin-like proteinases, TLPs) which includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

  2. NM_001193331.3 → NP_001180260.1  aminopeptidase O isoform 4

    See identical proteins and their annotated locations for NP_001180260.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks multiple 3' exons, but has an alternate 3' exon, as compared to variant 1. The resulting isoform (4) is much shorter and has a different C-terminus, as compared to isoform 1.
    Source sequence(s)
    AK057450, AK098242, AL353768, BX099259, DA521148
    Consensus CDS
    CCDS55327.1
    UniProtKB/Swiss-Prot
    Q8N6M6
    Related
    ENSP00000277198.2, ENST00000277198.6
    Conserved Domains (1) summary
    cl14813
    Location:244 → 509
    GluZincin; Gluzincin Peptidase family (thermolysin-like proteinases, TLPs) which includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

  3. NM_001386061.1 → NP_001372990.1  aminopeptidase O isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL157936, AL353768, AL354893
    Conserved Domains (2) summary
    pfam09127
    Location:291 → 341
    Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
    cl14813
    Location:141 → 222
    GluZincin; Gluzincin Peptidase family (thermolysin-like proteinases, TLPs) which includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

  4. NM_001386062.2 → NP_001372991.1  aminopeptidase O isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL157936, AL353768, AL354893
    Conserved Domains (2) summary
    pfam09127
    Location:614 → 711
    Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
    cl14813
    Location:317 → 545
    GluZincin; Gluzincin Peptidase family (thermolysin-like proteinases, TLPs) which includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

  5. NM_001386063.2 → NP_001372992.1  aminopeptidase O isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL157936, AL353768, AL354893
    Conserved Domains (2) summary
    pfam09127
    Location:675 → 772
    Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
    cl14813
    Location:244 → 652
    GluZincin; Gluzincin Peptidase family (thermolysin-like proteinases, TLPs) which includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

  6. NM_001386066.1 → NP_001372995.1  aminopeptidase O isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL157936, AL353768, AL354893
    Conserved Domains (2) summary
    pfam09127
    Location:721 → 771
    Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
    cl14813
    Location:244 → 652
    GluZincin; Gluzincin Peptidase family (thermolysin-like proteinases, TLPs) which includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

  7. NM_001386067.1 → NP_001372996.1  aminopeptidase O isoform 8

    Status: REVIEWED

    Source sequence(s)
    AL157936, AL353768, AL354893
    Conserved Domains (2) summary
    pfam09127
    Location:547 → 597
    Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
    cl14813
    Location:244 → 453
    GluZincin; Gluzincin Peptidase family (thermolysin-like proteinases, TLPs) which includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

  8. NM_001386068.1 → NP_001372997.1  aminopeptidase O isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL157936, AL353768, AL354893
    Conserved Domains (2) summary
    pfam09127
    Location:721 → 771
    Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
    cl14813
    Location:244 → 652
    GluZincin; Gluzincin Peptidase family (thermolysin-like proteinases, TLPs) which includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

  9. NM_001386069.1 → NP_001372998.1  aminopeptidase O isoform 9

    Status: REVIEWED

    Source sequence(s)
    AL157936, AL353768, AL354893
    Conserved Domains (2) summary
    pfam09127
    Location:622 → 672
    Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
    cl14813
    Location:244 → 553
    GluZincin; Gluzincin Peptidase family (thermolysin-like proteinases, TLPs) which includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

  10. NM_001386070.1 → NP_001372999.1  aminopeptidase O isoform 10

    Status: REVIEWED

    Source sequence(s)
    AL157936, AL353768, AL354893
    Conserved Domains (2) summary
    pfam09127
    Location:706 → 732
    Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
    cl14813
    Location:244 → 652
    GluZincin; Gluzincin Peptidase family (thermolysin-like proteinases, TLPs) which includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

  11. NM_001386071.1 → NP_001373000.1  aminopeptidase O isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL157936, AL353768
    Consensus CDS
    CCDS55327.1
    Conserved Domains (1) summary
    cl14813
    Location:244 → 509
    GluZincin; Gluzincin Peptidase family (thermolysin-like proteinases, TLPs) which includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

  12. NM_001386072.1 → NP_001373001.1  aminopeptidase O isoform 11

    Status: REVIEWED

    Source sequence(s)
    AL157936, AL353768
    Conserved Domains (1) summary
    cl14813
    Location:244 → 509
    GluZincin; Gluzincin Peptidase family (thermolysin-like proteinases, TLPs) which includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

  13. NM_001386073.1 → NP_001373002.1  aminopeptidase O isoform 12

    Status: REVIEWED

    Source sequence(s)
    AL157936, AL353768
    Conserved Domains (1) summary
    cl14813
    Location:2 → 219
    GluZincin; Gluzincin Peptidase family (thermolysin-like proteinases, TLPs) which includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

  14. NM_001386074.1 → NP_001373003.1  aminopeptidase O isoform 13

    Status: REVIEWED

    Source sequence(s)
    AL157936, AL353768, AL354893
    Conserved Domains (2) summary
    pfam09127
    Location:721 → 771
    Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
    cl14813
    Location:244 → 652
    GluZincin; Gluzincin Peptidase family (thermolysin-like proteinases, TLPs) which includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

  15. NM_001386075.1 → NP_001373004.1  aminopeptidase O isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL157936, AL353768, AL354893
    Consensus CDS
    CCDS55328.1
    UniProtKB/Swiss-Prot
    Q5T9B1, Q5T9B3, Q5T9B4, Q8N6M6, Q8WUL6, Q96M23, Q96SS1
    Conserved Domains (2) summary
    pfam09127
    Location:721 → 818
    Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
    cl14813
    Location:244 → 652
    GluZincin; Gluzincin Peptidase family (thermolysin-like proteinases, TLPs) which includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

  16. NM_001386076.1 → NP_001373005.1  aminopeptidase O isoform 14

    Status: REVIEWED

    Source sequence(s)
    AL157936, AL353768
    Conserved Domains (1) summary
    cl14813
    Location:244 → 652
    GluZincin; Gluzincin Peptidase family (thermolysin-like proteinases, TLPs) which includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

  17. NM_032823.6 → NP_116212.3  aminopeptidase O isoform 2

    See identical proteins and their annotated locations for NP_116212.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two consecutive in-frame exons in the CDS, as compared to variant 1. The resulting isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AI982632, AL354893, BC029616, DA521148
    Consensus CDS
    CCDS6713.1
    UniProtKB/Swiss-Prot
    Q8N6M6
    Related
    ENSP00000297979.5, ENST00000297979.9
    Conserved Domains (2) summary
    pfam09127
    Location:617 → 718
    Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
    cl14813
    Location:186 → 533
    GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

RNA

  1. NR_169862.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL157936, AL353768, AL354893

  2. NR_169863.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL157936, AL353768, AL354893

  3. NR_169864.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL157936, AL353768, AL354893

  4. NR_169865.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL157936, AL353768, AL354893

  5. NR_169866.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL157936, AL353768, AL354893

  6. NR_169867.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL353768, AL354893

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    94726699..95150224
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011519121.4 → XP_011517423.1  aminopeptidase O isoform X2

    Conserved Domains (2) summary
    cd09595
    Location:186 → 632
    M1; Peptidase M1 family contains aminopeptidase N and leukotriene A4 hydrolase
    pfam09127
    Location:716 → 781
    Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal

  2. XM_047423984.1 → XP_047279940.1  aminopeptidase O isoform X5

  3. XM_017015234.3 → XP_016870723.1  aminopeptidase O isoform X12

    Conserved Domains (2) summary
    pfam09127
    Location:419 → 474
    Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
    cl14813
    Location:27 → 335
    GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

  4. XM_017015236.3 → XP_016870725.1  aminopeptidase O isoform X15

  5. XM_047423978.1 → XP_047279934.1  aminopeptidase O isoform X1

    UniProtKB/Swiss-Prot
    Q5T9B1, Q5T9B3, Q5T9B4, Q8N6M6, Q8WUL6, Q96M23, Q96SS1

  6. XM_017015231.3 → XP_016870720.1  aminopeptidase O isoform X6

    UniProtKB/Swiss-Prot
    Q8N6M6
    Conserved Domains (2) summary
    pfam09127
    Location:617 → 718
    Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
    cl14813
    Location:186 → 533
    GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

  7. XM_047423987.1 → XP_047279943.1  aminopeptidase O isoform X13

  8. XM_017015237.3 → XP_016870726.1  aminopeptidase O isoform X17

  9. XM_047423983.1 → XP_047279939.1  aminopeptidase O isoform X4

  10. XM_047423981.1 → XP_047279937.1  aminopeptidase O isoform X4

  11. XM_047423980.1 → XP_047279936.1  aminopeptidase O isoform X4

  12. XM_017015232.3 → XP_016870721.1  aminopeptidase O isoform X8

  13. XM_047423985.1 → XP_047279941.1  aminopeptidase O isoform X11

  14. XM_047423988.1 → XP_047279944.1  aminopeptidase O isoform X18

  15. XM_047423982.1 → XP_047279938.1  aminopeptidase O isoform X4

  16. XM_011519123.4 → XP_011517425.1  aminopeptidase O isoform X9

    Conserved Domains (1) summary
    cd09595
    Location:186 → 632
    M1; Peptidase M1 family contains aminopeptidase N and leukotriene A4 hydrolase

  17. XM_011519122.4 → XP_011517424.1  aminopeptidase O isoform X7

    Conserved Domains (1) summary
    cd09595
    Location:186 → 632
    M1; Peptidase M1 family contains aminopeptidase N and leukotriene A4 hydrolase

  18. XM_011519127.3 → XP_011517429.1  aminopeptidase O isoform X10

    Conserved Domains (1) summary
    cd09595
    Location:186 → 625
    M1; Peptidase M1 family contains aminopeptidase N and leukotriene A4 hydrolase

  19. XM_011519130.3 → XP_011517432.1  aminopeptidase O isoform X14

    Conserved Domains (1) summary
    cl14813
    Location:186 → 456
    GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

  20. XM_011519134.4 → XP_011517436.1  aminopeptidase O isoform X16

    Conserved Domains (1) summary
    cl14813
    Location:186 → 455
    GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

  21. XM_047423979.1 → XP_047279935.1  aminopeptidase O isoform X3

  22. XM_047423986.1 → XP_047279942.1  aminopeptidase O isoform X12

  23. XM_011519132.2 → XP_011517434.1  aminopeptidase O isoform X19

    Conserved Domains (2) summary
    pfam09127
    Location:336 → 391
    Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
    cl14813
    Location:1 → 252
    GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

RNA

  1. XR_929854.3 RNA Sequence

  2. XR_929853.3 RNA Sequence

  3. XR_007061364.1 RNA Sequence

  4. XR_007061363.1 RNA Sequence

  5. XR_929855.3 RNA Sequence

  6. XR_929857.3 RNA Sequence

  7. XR_007061365.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    106896013..107317676
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054364031.1 → XP_054220006.1  aminopeptidase O isoform X2

  2. XM_054364037.1 → XP_054220012.1  aminopeptidase O isoform X5

  3. XM_054364044.1 → XP_054220019.1  aminopeptidase O isoform X12

  4. XM_054364048.1 → XP_054220023.1  aminopeptidase O isoform X15

  5. XM_054364030.1 → XP_054220005.1  aminopeptidase O isoform X1

    UniProtKB/Swiss-Prot
    Q5T9B1, Q5T9B3, Q5T9B4, Q8N6M6, Q8WUL6, Q96M23, Q96SS1

  6. XM_054364038.1 → XP_054220013.1  aminopeptidase O isoform X6

  7. XM_054364046.1 → XP_054220021.1  aminopeptidase O isoform X13

  8. XM_054364050.1 → XP_054220025.1  aminopeptidase O isoform X17

  9. XM_054364036.1 → XP_054220011.1  aminopeptidase O isoform X4

  10. XM_054364034.1 → XP_054220009.1  aminopeptidase O isoform X4

  11. XM_054364033.1 → XP_054220008.1  aminopeptidase O isoform X4

  12. XM_054364040.1 → XP_054220015.1  aminopeptidase O isoform X8

  13. XM_054364043.1 → XP_054220018.1  aminopeptidase O isoform X11

  14. XM_054364051.1 → XP_054220026.1  aminopeptidase O isoform X18

  15. XM_054364035.1 → XP_054220010.1  aminopeptidase O isoform X4

  16. XM_054364041.1 → XP_054220016.1  aminopeptidase O isoform X9

  17. XM_054364039.1 → XP_054220014.1  aminopeptidase O isoform X7

  18. XM_054364042.1 → XP_054220017.1  aminopeptidase O isoform X10

  19. XM_054364047.1 → XP_054220022.1  aminopeptidase O isoform X14

  20. XM_054364049.1 → XP_054220024.1  aminopeptidase O isoform X16

  21. XM_054364032.1 → XP_054220007.1  aminopeptidase O isoform X3

  22. XM_054364045.1 → XP_054220020.1  aminopeptidase O isoform X12

RNA

  1. XR_008488088.1 RNA Sequence

  2. XR_008488087.1 RNA Sequence

  3. XR_008488091.1 RNA Sequence

  4. XR_008488090.1 RNA Sequence

  5. XR_008488089.1 RNA Sequence

  6. XR_008488092.1 RNA Sequence

  7. XR_008488093.1 RNA Sequence

  8. XR_008488094.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001193330.1: Suppressed sequence

    Description
    NM_001193330.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N6M6.2 GenPept UniProtKB/Swiss-Prot:Q8N6M6

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