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SLC35B4 solute carrier family 35 member B4 [ Homo sapiens (human) ]

Gene ID: 84912, updated on 11-Apr-2024

Summary

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Official Symbol
SLC35B4provided by HGNC
Official Full Name
solute carrier family 35 member B4provided by HGNC
Primary source
HGNC:HGNC:20584
See related
Ensembl:ENSG00000205060 MIM:610923; AllianceGenome:HGNC:20584
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
YEA; YEA4
Summary
Glycosyltransferases, such as SLC35B4, transport nucleotide sugars from the cytoplasm where they are synthesized, to the Golgi apparatus where they are utilized in the synthesis of glycoproteins, glycolipids, and proteoglycans (Ashikov et al., 2005 [PubMed 15911612]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in placenta (RPKM 6.0), brain (RPKM 5.9) and 24 other tissues See more
Orthologs
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Genomic context

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See SLC35B4 in Genome Data Viewer
Location:
7q33
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (134289332..134320338, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (135597448..135628436, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (133974084..134001682, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene exocyst complex component 4 Neighboring gene uncharacterized LOC105375514 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26687 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26688 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:133814671-133815405 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18670 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:133874107-133874656 Neighboring gene leucine rich repeats and guanylate kinase domain containing Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18671 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18672 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26689 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:134050229-134051428 Neighboring gene uncharacterized LOC105375518 Neighboring gene uncharacterized LOC105375517 Neighboring gene long intergenic non-protein coding RNA 3060

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Lysine at position 329 within a C-terminal dilysine motif is crucial for the ER localization of human SLC35B4. Bazan B, et al. PLoS One, 2018. PMID 30458018, Free PMC Article
  2. A common regulatory variant in SLC35B4 influences the recurrence and survival of prostate cancer. Huang EY, et al. J Cell Mol Med, 2018 Jul. PMID 29682886, Free PMC Article
  3. Molecular and functional characterization of microsomal UDP-glucuronic acid uptake by members of the nucleotide sugar transporter (NST) family. Kobayashi T, et al. Biochem J, 2006 Dec 1. PMID 16965264, Free PMC Article
  4. A novel YAP1/SLC35B4 regulatory axis contributes to proliferation and progression of gastric carcinoma. Liu J, et al. Cell Death Dis, 2019 Jun 7. PMID 31175271, Free PMC Article
  5. SLC35B4, an Inhibitor of Gluconeogenesis, Responds to Glucose Stimulation and Downregulates Hsp60 among Other Proteins in HepG2 Liver Cell Lines. Wex B, et al. Molecules, 2018 Jun 4. PMID 29867058, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A novel YAP1/SLC35B4 axis promotes gastric cancer (GC) development and progression, and this axis could be a potential candidate for prognosis and therapeutics in GC.
    Title: A novel YAP1/SLC35B4 regulatory axis contributes to proliferation and progression of gastric carcinoma.
  2. SLC35B4 single nucleotide polymorphism rs1646724 was associated with recurrence in patients with localized disease and survival in patients with advanced prostate cancer.
    Title: A common regulatory variant in SLC35B4 influences the recurrence and survival of prostate cancer.
  3. Our data showed that knock-out of the SLC35B4 gene does not affect major UDP-Xyl- and UDP-GlcNAc-dependent glycosylation pathways.
    Title: Lysine at position 329 within a C-terminal dilysine motif is crucial for the ER localization of human SLC35B4.
  4. Glucose levels activate SLC35B4 expression. This triggers a downstream effect via Hsp60 and other proteins. We hypothesize that the downstream effect on the proteins is mediated via altering the glycosylation pattern inside liver cells
    Title: SLC35B4, an Inhibitor of Gluconeogenesis, Responds to Glucose Stimulation and Downregulates Hsp60 among Other Proteins in HepG2 Liver Cell Lines.
  5. subcellular localization of SLC35B4
    Title: Subcellular localization of UDP-GlcNAc, UDP-Gal and SLC35B4 transporters.
  6. Decreased SLC35B4 expression led to increased gluconeogenesis in HepG2 cells.
    Title: Deep congenic analysis identifies many strong, context-dependent QTLs, one of which, Slc35b4, regulates obesity and glucose homeostasis.
  7. Transport capabilities for UDP-Glc and UDP-Xyl were determined with Golgi vesicles isolated from transformed cells
    Title: The human solute carrier gene SLC35B4 encodes a bifunctional nucleotide sugar transporter with specificity for UDP-xylose and UDP-N-acetylglucosamine.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ14697

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables UDP-N-acetylglucosamine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP-N-acetylglucosamine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables UDP-N-acetylglucosamine transmembrane transporter activity TAS
Traceable Author Statement
more info
  
enables UDP-xylose transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP-xylose transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables UDP-xylose transmembrane transporter activity TAS
Traceable Author Statement
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in UDP-N-acetylglucosamine transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in UDP-N-acetylglucosamine transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in UDP-xylose transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of gluconeogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane TAS
Traceable Author Statement
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
nucleotide sugar transporter SLC35B4
Names
UDP-Xylose/N-Acetylglucosamine transporter
UDP-xylose and UDP-N-acetylglucosamine transporter
YEA4 homolog
solute carrier family 35 (UDP-xylose/UDP-N-acetylglucosamine transporter), member B4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032826.5 → NP_116215.1  nucleotide sugar transporter SLC35B4

    See identical proteins and their annotated locations for NP_116215.1

    Status: VALIDATED

    Source sequence(s)
    AB052892, AC008154
    Consensus CDS
    CCDS34756.1
    UniProtKB/Swiss-Prot
    A4D1P3, A6NNS4, Q53GQ7, Q8TCU7, Q969S0, Q96K33
    Related
    ENSP00000367770.4, ENST00000378509.9
    Conserved Domains (1) summary
    pfam08449
    Location:2 → 314
    UAA; UAA transporter family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    134289332..134320338 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011516645.4 → XP_011514947.1  nucleotide sugar transporter SLC35B4 isoform X1

    Conserved Domains (2) summary
    pfam08449
    Location:28 → 314
    UAA; UAA transporter family
    cl23754
    Location:87 → 310
    EamA; EamA-like transporter family

  2. XM_047420996.1 → XP_047276952.1  nucleotide sugar transporter SLC35B4 isoform X2

RNA

  1. XR_001744890.3 RNA Sequence

  2. XR_001744889.3 RNA Sequence

  3. XR_001744888.3 RNA Sequence

  4. XR_001744887.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    135597448..135628436 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054359276.1 → XP_054215251.1  nucleotide sugar transporter SLC35B4 isoform X1

  2. XM_054359277.1 → XP_054215252.1  nucleotide sugar transporter SLC35B4 isoform X2

RNA

  1. XR_008487771.1 RNA Sequence

  2. XR_008487772.1 RNA Sequence

  3. XR_008487770.1 RNA Sequence

  4. XR_008487769.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q969S0.1 GenPept UniProtKB/Swiss-Prot:Q969S0

Gene LinkOut

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