PIK3R3 phosphoinositide-3-kinase regulatory subunit 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PIK3R3provided by HGNC
Official Full Name: phosphoinositide-3-kinase regulatory subunit 3provided by HGNC
Primary source: HGNC:HGNC:8981
See related: Ensembl:ENSG00000117461 MIM:606076; AllianceGenome:HGNC:8981
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: p55; p55PIK; p55-GAMMA
Summary: Phosphatidylinositol 3-kinase (PI3K) phosphorylates phosphatidylinositol and similar compounds, which then serve as second messengers in growth signaling pathways. PI3K is composed of a catalytic and a regulatory subunit. The protein encoded by this gene represents a regulatory subunit of PI3K. The encoded protein contains two SH2 domains through which it binds activated protein tyrosine kinases to regulate their activity. [provided by RefSeq, Jun 2016]
Expression: Broad expression in testis (RPKM 19.6), fat (RPKM 8.4) and 20 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p34.1

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (46040140..46174901, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (45917331..46052095, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (46505812..46640573, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

VHL governs m6A modification and PIK3R3 mRNA stability in clear cell renal cell carcinomas.
Title: VHL governs m6A modification and PIK3R3 mRNA stability in clear cell renal cell carcinomas.
p55gamma degrades RIP3 via MG53 to suppress ischaemia-induced myocardial necroptosis and mediates cardioprotection of preconditioning.
Title: p55γ degrades RIP3 via MG53 to suppress ischaemia-induced myocardial necroptosis and mediates cardioprotection of preconditioning.
PIK3R3 is upregulated in liver cancer and activates Akt signaling to control cancer growth by regulation of CDKN1C and SMC1A.
Title: PIK3R3 is upregulated in liver cancer and activates Akt signaling to control cancer growth by regulation of CDKN1C and SMC1A.
PIK3R3 Missense and NOTCH2 Synonymous Single Nucleotide Polymorphisms Are Associated with Liver Cancer.
Title: PIK3R3 Missense and NOTCH2 Synonymous Single Nucleotide Polymorphisms Are Associated with Liver Cancer.
KMT2C Induced by FABP5P3 Aggravates Keratinocyte Hyperproliferation and Psoriasiform Skin Inflammation by Upregulating the Transcription of PIK3R3.
Title: KMT2C Induced by FABP5P3 Aggravates Keratinocyte Hyperproliferation and Psoriasiform Skin Inflammation by Upregulating the Transcription of PIK3R3.
PIK3R3, a regulatory subunit of PI3K, modulates ovarian cancer stem cells and ovarian cancer development and progression by integrative analysis.
Title: PIK3R3, a regulatory subunit of PI3K, modulates ovarian cancer stem cells and ovarian cancer development and progression by integrative analysis.
LncRNA JHDM1D-AS1 Suppresses MPP + -Induced Neuronal Injury in Parkinson's Disease via miR-134-5p/PIK3R3 Axis.
Title: LncRNA JHDM1D-AS1 Suppresses MPP + -Induced Neuronal Injury in Parkinson's Disease via miR-134-5p/PIK3R3 Axis.
p55PIK deficiency and its NH2-terminal derivative inhibit inflammation and emphysema in COPD mouse model.
Title: p55PIK deficiency and its NH(2)-terminal derivative inhibit inflammation and emphysema in COPD mouse model.
MiR-513b-5p represses autophagy during the malignant progression of hepatocellular carcinoma by targeting PIK3R3.
Title: MiR-513b-5p represses autophagy during the malignant progression of hepatocellular carcinoma by targeting PIK3R3.
Inhibition of exosomal miR-24-3p in diabetes restores angiogenesis and facilitates wound repair via targeting PIK3R3.
Title: Inhibition of exosomal miR-24-3p in diabetes restores angiogenesis and facilitates wound repair via targeting PIK3R3.

Submit: New GeneRIF Correction See all GeneRIFs (42)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH16484 (e-PCR)
- UniSTS:56633

SHGC-74772 (e-PCR)
- UniSTS:48989

RH121843 (e-PCR)
- UniSTS:134504

AL009584 (e-PCR)
- UniSTS:16514

A008Z33 (e-PCR)
- UniSTS:15800

G32343 (e-PCR)
- UniSTS:116934

RH93118 (e-PCR)
- UniSTS:91598

A006G09 (e-PCR)
- UniSTS:6864

Readthrough P3R3URF-PIK3R3

Readthrough gene: P3R3URF-PIK3R3, Included gene: P3R3URF

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-3-kinase activity	TAS Traceable Author Statement more info	PubMed
enables 1-phosphatidylinositol-3-kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphotyrosine residue binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in B cell differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in T cell differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in cell migration involved in sprouting angiogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in immune response	NAS Non-traceable Author Statement more info	PubMed
involved_in insulin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of anoikis	NAS Non-traceable Author Statement more info	PubMed
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylinositol phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol-3-phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell migration	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	TAS Traceable Author Statement more info
part_of phosphatidylinositol 3-kinase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of phosphatidylinositol 3-kinase complex, class IA	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: phosphatidylinositol 3-kinase regulatory subunit gamma

Names: PI3-kinase regulatory subunit gamma; PI3-kinase subunit p55-gamma; PI3K regulatory subunit gamma; phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 3 (p55, gamma); phosphoinositide-3-kinase, regulatory subunit 3 (gamma); ptdIns-3-kinase regulatory subunit p55-gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_050949.1 RefSeqGene

Range

48867..141356

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001114172.1 → NP_001107644.1 phosphatidylinositol 3-kinase regulatory subunit gamma isoform 1

See identical proteins and their annotated locations for NP_001107644.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AK313726, BC021622, U90907

Consensus CDS

CCDS529.1

UniProtKB/Swiss-Prot

B2R9C1, D3DQ12, O60482, Q5T4P1, Q5T4P2, Q92569

UniProtKB/TrEMBL

Q8N381

Related

ENSP00000412546.1, ENST00000420542.5

Conserved Domains (4) summary

cd09930
Location:351 → 454

SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85

cd09942
Location:59 → 167

SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85

pfam16454
Location:171 → 330

PI3K_P85_iSH2; Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain

cl23765
Location:172 → 332

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
NM_001303428.1 → NP_001290357.1 phosphatidylinositol 3-kinase regulatory subunit gamma isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (4) contains an alternate exon and uses an alternate splice site in the 5' coding region. These differences cause translation initiation at an upstream start codon compared to variant 1. The encoded isoform (3) has a longer N-terminus than isoform 1.

Source sequence(s)

AK302049, BX537388, CR749649

UniProtKB/TrEMBL

Q7Z3W2

Conserved Domains (4) summary

cd09930
Location:368 → 471

SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85

cd09942
Location:76 → 184

SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85

cd12925
Location:189 → 349

iSH2_PIK3R3; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 3, PIK3R3, also called p55gamma

pfam16454
Location:188 → 347

PI3K_P85_iSH2; Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
NM_001303429.2 → NP_001290358.1 phosphatidylinositol 3-kinase regulatory subunit gamma isoform 4

See identical proteins and their annotated locations for NP_001290358.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks an alternate in-frame exon in the central coding region compared to variant 1. The encoded isoform (4) is shorter than isoform 1.

Source sequence(s)

AF028785, BC021622, BX507484, BX537388, CR749649

Consensus CDS

CCDS76154.1

UniProtKB/TrEMBL

Q8N381

Related

ENSP00000391431.1, ENST00000423209.5

Conserved Domains (3) summary

cd09930
Location:292 → 395

SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85

cd09942
Location:59 → 167

SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85

cl25402
Location:172 → 273

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
NM_001328648.1 → NP_001315577.1 phosphatidylinositol 3-kinase regulatory subunit gamma isoform 5

Status: REVIEWED

Description

Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (5) is shorter at the N-terminus compared to isoform 1. Variants 6, 7, 8, and 9 all encode the same isoform (5).

Source sequence(s)

AL358075, AL672043

UniProtKB/TrEMBL

Q8N381
NM_001328649.1 → NP_001315578.1 phosphatidylinositol 3-kinase regulatory subunit gamma isoform 5

Status: REVIEWED

Description

Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (5) is shorter at the N-terminus compared to isoform 1. Variants 6, 7, 8, and 9 all encode the same isoform (5).

Source sequence(s)

AL358075

UniProtKB/TrEMBL

Q8N381
NM_001328650.1 → NP_001315579.1 phosphatidylinositol 3-kinase regulatory subunit gamma isoform 5

Status: REVIEWED

Description

Transcript Variant: This variant (8) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (5) is shorter at the N-terminus compared to isoform 1. Variants 6, 7, 8, and 9 all encode the same isoform (5).

Source sequence(s)

AL358075

UniProtKB/TrEMBL

Q8N381
NM_001328651.1 → NP_001315580.1 phosphatidylinositol 3-kinase regulatory subunit gamma isoform 5

Status: REVIEWED

Description

Transcript Variant: This variant (9) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (5) is shorter at the N-terminus compared to isoform 1. Variants 6, 7, 8, and 9 all encode the same isoform (5).

Source sequence(s)

AL358075

UniProtKB/TrEMBL

Q8N381
NM_001328652.2 → NP_001315581.1 phosphatidylinositol 3-kinase regulatory subunit gamma isoform 6

Status: REVIEWED

Description

Transcript Variant: This variant (10) lacks an alternate in-frame exon in the 3' end compared to variant 1. The resulting isoform (6) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AL358075

UniProtKB/TrEMBL

Q8N381
NM_001328653.2 → NP_001315582.1 phosphatidylinositol 3-kinase regulatory subunit gamma isoform 7

Status: REVIEWED

Description

Transcript Variant: This variant (11) lacks an alternate exon in the 5' end and uses a downstream start codon compared to variant 1. The resulting isoform (7) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AL358075

UniProtKB/TrEMBL

Q8N381
NM_001328654.2 → NP_001315583.1 phosphatidylinositol 3-kinase regulatory subunit gamma isoform 8

Status: REVIEWED

Description

Transcript Variant: This variant (12) lacks two alternate exons in the 5' end and uses a downstream start codon compared to variant 1. The resulting isoform (8) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AL358075

UniProtKB/TrEMBL

B4E3G5
NM_003629.4 → NP_003620.3 phosphatidylinositol 3-kinase regulatory subunit gamma isoform 1

See identical proteins and their annotated locations for NP_003620.3

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

BC021622, BC094768, U90907

Consensus CDS

CCDS529.1

UniProtKB/Swiss-Prot

B2R9C1, D3DQ12, O60482, Q5T4P1, Q5T4P2, Q92569

UniProtKB/TrEMBL

Q8N381

Related

ENSP00000262741.5, ENST00000262741.10

Conserved Domains (4) summary

cd09930
Location:351 → 454

SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85

cd09942
Location:59 → 167

SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85

pfam16454
Location:171 → 330

PI3K_P85_iSH2; Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain

cl23765
Location:172 → 332

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

RNA

NR_137329.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (14) lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.

Source sequence(s)

AL358075