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ILV6 acetolactate synthase regulatory subunit [ Saccharomyces cerevisiae S288C ]

Gene ID: 850348, updated on 5-May-2024

Summary

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Gene symbol
ILV6
Gene description
acetolactate synthase regulatory subunit
Primary source
SGD:S000000515
Locus tag
YCL009C
See related
AllianceGenome:SGD:S000000515
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables enzyme regulator activity. Contributes to acetolactate synthase activity. Involved in branched-chain amino acid biosynthetic process. Located in mitochondrial nucleoid. Part of acetolactate synthase complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_001135.5 (104619..105548, complement)

Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene single-stranded telomeric DNA-binding/mRNA-binding protein Neighboring gene Sgf29p Neighboring gene ubiquitin-binding ESCRT-I subunit protein STP22 Neighboring gene H(+)-transporting V0 sector ATPase subunit e

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001135.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. High-level production of valine by expression of the feedback inhibition-insensitive acetohydroxyacid synthase in Saccharomyces cerevisiae. Takpho N, et al. Metab Eng, 2018 Mar. PMID 29477860
  2. Variation in α-acetolactate production within the hybrid lager yeast group Saccharomyces pastorianus and affirmation of the central role of the ILV6 gene. Gibson B, et al. Yeast, 2015 Jan. PMID 24965182
  3. Identification of Sc-type ILV6 as a target to reduce diacetyl formation in lager brewers' yeast. Duong CT, et al. Metab Eng, 2011 Nov. PMID 21824525
  4. Mutations in the regulatory subunit of yeast acetohydroxyacid synthase affect its activation by MgATP. Lee YT, et al. Biochem J, 2006 Apr 15. PMID 16390333, Free PMC Article
  5. Functional analysis of YCL09C: evidence for a role as the regulatory subunit of acetolactate synthase. Cullin C, et al. Yeast, 1996 Dec. PMID 8972574

See all (69) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables acetolactate synthase regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables enzyme regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables enzyme regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in branched-chain amino acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in branched-chain amino acid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in branched-chain amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in isoleucine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in valine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of acetolactate synthase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of acetolactate synthase complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitochondrial nucleoid IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial nucleoid IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
acetolactate synthase regulatory subunit
NP_009918.1
  • Regulatory subunit of acetolactate synthase; acetolactate synthase catalyzes the first step of branched-chain amino acid biosynthesis; enhances activity of the Ilv2p catalytic subunit, localizes to mitochondria

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001135.5 Reference assembly

    Range
    104619..105548 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178658.1 → NP_009918.1  TPA: acetolactate synthase regulatory subunit [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009918.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VR03, P25605, P87009
    UniProtKB/TrEMBL
    A0A8H4BTR1, A6ZTH5, B3LU66, C7GQK9, N1PAP6
    Conserved Domains (1) summary
    TIGR00119
    Location:77 → 282
    acolac_sm; acetolactate synthase, small subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25605.2

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