PGS1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: PGS1
Gene description: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
Primary source: SGD:S000000510
Locus tag: YCL004W
See related: AllianceGenome:SGD:S000000510
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: PEL1; YCL003W
Summary: Enables CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity. Involved in cardiolipin biosynthetic process. Located in mitochondrion. Orthologous to human PGS1 (phosphatidylglycerophosphate synthase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: III

Exon count:: 1

Sequence:: Chromosome: III; NC_001135.5 (109105..110670)

Chromosome III - NC_001135.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001135.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pgs1p is essential for cell wall biogenesis and activation of the PKC-Slt2 signaling pathway
Title: Up-regulation of the cell integrity pathway in saccharomyces cerevisiae suppresses temperature sensitivity of the pgs1Delta mutant.
Using tetrad analysis of diploids issued from corresponding crosses a synthetic lethal interaction has been observed between the op1 and pel1 mutations resulting in the lack of growth of a corresponding double mutant on minimal medium containing glucose.
Title: Synthetic lethal interaction between the pel1 and op1 mutations in Saccharomyces cerevisiae.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cardiolipin biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cardiolipin biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cardiolipin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylglycerol biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phospholipid biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase

NP_009923.2

EC 2.7.8.5

Phosphatidylglycerolphosphate synthase; catalyzes the synthesis of phosphatidylglycerolphosphate from CDP-diacylglycerol and sn-glycerol 3-phosphate in the first committed and rate-limiting step of cardiolipin biosynthesis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001135.5 Reference assembly

Range

109105..110670

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178653.1 → NP_009923.2 TPA: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009923.2

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VR07, O93974, P25570, P25578, P87011

UniProtKB/TrEMBL

A0A8H4F921, A6ZTH9, B3LU70, B5VEU7, C7GQL2, C8Z481, G2WA15

Conserved Domains (2) summary

cd09135
Location:64 → 230

PLDc_PGS1_euk_1; Catalytic domain, repeat 1, of eukaryotic PhosphatidylGlycerophosphate Synthases

cd09137
Location:295 → 498

PLDc_PGS1_euk_2; Catalytic domain, repeat 2, of eukaryotic phosphatidylglycerophosphate synthases