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SLM5 asparagine--tRNA ligase SLM5 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850388, updated on 11-Apr-2024

Summary

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Gene symbol
SLM5
Gene description
asparagine--tRNA ligase SLM5
Primary source
SGD:S000000618
Locus tag
YCR024C
See related
AllianceGenome:SGD:S000000618
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables asparagine-tRNA ligase activity. Involved in mitochondrial asparaginyl-tRNA aminoacylation. Located in mitochondrion. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 94 and combined oxidative phosphorylation deficiency 24. Orthologous to human NARS2 (asparaginyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_001135.5 (160744..162222, complement)

Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene proteolipid ATPase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001135.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mitochondrial asparaginyl-tRNA synthetase is encoded by the yeast nuclear gene YCR24c. Landrieu I, et al. Eur J Biochem, 1997 Jan 15. PMID 9030748
  2. The complete sequence of K3B, a 7.9 kb fragment between PGK1 and CRY1 on chromosome III, reveals the presence of seven open reading frames. Bolle PA, et al. Yeast, 1992 Mar. PMID 1574926
  3. The Pif1 helicase is actively inhibited during meiotic recombination which restrains gene conversion tract length. Vernekar DV, et al. Nucleic Acids Res, 2021 May 7. PMID 33823531, Free PMC Article
  4. Genome-wide deletion mutant analysis reveals genes required for respiratory growth, mitochondrial genome maintenance and mitochondrial protein synthesis in Saccharomyces cerevisiae. Merz S, et al. Genome Biol, 2009. PMID 19751518, Free PMC Article
  5. Genome-wide lethality screen identifies new PI4,5P2 effectors that regulate the actin cytoskeleton. Audhya A, et al. EMBO J, 2004 Oct 1. PMID 15372071, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables asparagine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables asparagine-tRNA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables asparagine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in asparaginyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in asparaginyl-tRNA aminoacylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in asparaginyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial asparaginyl-tRNA aminoacylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
asparagine--tRNA ligase SLM5
NP_009953.1
  • Mitochondrial asparaginyl-tRNA synthetase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001135.5 Reference assembly

    Range
    160744..162222 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178738.1 → NP_009953.1  TPA: asparagine--tRNA ligase SLM5 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009953.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VR33, P25345
    UniProtKB/TrEMBL
    A0A8H4F6C7, A6ZTK5, B3LU95, B5VEX1, C7GW72, G2WA41, N1P840
    Conserved Domains (1) summary
    TIGR00457
    Location:16 → 492
    asnS; asparaginyl-tRNA synthetase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25345.1

Gene LinkOut

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